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Biomedical subjects

K Huddleston

Publications and source records attributed to K Huddleston.

6 recordsLinked to original sources
PubMed1997

Neonatal Torulopsis glabrata fungemia.

Torulopsis glabrata is a yeastlike fungus that has recently become recognized as an important opportunistic pathogen. Only four cases of T glabrata infection in neonates have been reported. We report two cases of fungemia caused by this organism in premature infants. Both patients were treated with amphotericin B and survived the fungemia, but one patient later died of bacterial sepsis. Both patients had been treated with surfactant, artificial ventilation, intravascular catheters (arterial and venous), broad spectrum antibiotics, and hyperalimentation, which appear to be risk factors for T glabrata fungemia. A review of the literature indicates that T glabrata is susceptible to amphotericin B and 5-fluorocytosine and is resistant to fluconazole. In addition, it is less susceptible to ketoconazole, clotrimazole, and itraconazole than is Candida albicans. We recommend that T glabrata infections be treated initially by reducing iatrogenic risk factors and beginning amphotericin B therapy. If necessary, 5-fluorocytosine should be added to the drug regimen.

Amphotericin B↗
PubMed1986

An additional case of Smith-Lemli-Opitz syndrome in a 46,XY infant with female external genitalia.

Ambiguity of the external genitalia has been frequently documented in male patients classified as the Smith-Lemli-Opitz (SLO) syndrome. Four previous case reports suggest that in extreme cases of the SLO syndrome there may be complete lack of development of the male external genitalia even in the presence of a normal male 46,XY karyotype. We present an additional case of a phenotypically female infant with dysmorphic features compatible with SLO syndrome and a 46,XY chromosome complement.

Abnormalities, Multiple↗
PubMedDate not supplied

A comparison of infusion devices at 1 ml/hr.

Delivery of medications by some infusion devices is irregular. This study investigated instantaneous flow in several infusion devices set at a rate of 1 ml/hr. The following devices were tested: Infusion Pumps: IMED 956A, IVAC 570, IVION "Kids Pump." Syringe Pumps: Medfusion, Baxter, Baxter OR. Tests were performed using a Bio-Tek Infusion Device Analyzer (Model IDA-1). Instantaneous flow rate was defined as Q1/T1 where: Q=sample volume and T=time required to deliver sample volume. The infusion devices were received directly from their respective manufacturers and had not seen clinical service before testing. The units were fully charged and were tested while on AC power. The tests were conducted by the authors, using standard infusion sets and commercially prepared 5% dextrose and 0.45% sodium chloride solution. Each pump was tested for several hours and multiple trials were performed on each pump. The infusion pumps, IMED, IVION, and IVAC all demonstrated deviations from the desired flow rate. The IVAC pump had a greater fluctuation in flow from the set value of 1 ml/hr (p less than 0.02). Variances from mean +/- standard error for each device are shown in parenthesis. IMED 965A (0.005+/-0.014), IVION Kid's Pump (0.002+/-0.009), IVAC 570 (0.001+/-0.006). The Baxter syringe pump (0.002+/-0.009) also had a wide variance in flow. The Baxter OR (0.001+/-0.005) and the Medfusion (0.001+/-0.008) syringe pumps maintained the most consistent flow and showed less variance than the other devices tested.(ABSTRACT TRUNCATED AT 250 WORDS)

Drug Therapy↗