PubMed Health⌕ Search

Biomedical subjects

K Huygen

Publications and source records attributed to K Huygen.

113 records · Page 7Linked to original sources
PubMed1981

E-5-(2-bromovinyl)-2'-deoxyuridine vs. interferon in the systemic treatment of infection with herpes simplex virus of athymic nude mice.

The effects of systemic administration of E-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and interferon (IFN)--mouse IFN type I (MuIFN-alpha plus -beta), mouse IFN type II (MuIFN-gamma), and polyriboinosinic-polyribocytidylic acid (an IFN inducer)--on the development of herpetic skin lesions and associated mortality were studied in athymic nude (nu/nu) mice inoculated intracutaneously with herpes simplex virus (HSV) type 1 (strain KOS). BVDU was given intraperitoneally or orally at dosages of up to 5 mg per mouse per day; IFN and polyriboinosinic-polyribocytidylic acid were given intraperitoneally at dosages of up to 10(6) units per mouse per day and 100 microgram per mouse per day, respectively. Under conditions in which BVDU effectively suppressed the progression of the disease, IFN and polyriboinosinic-polyribocytidylic acid failed to suppress the disease. Thus, BVDU was superior to IFN in the treatment of HSV infection in immunologically compromised mice.

Animals↗
PubMedDate not supplied

Effects of selenium supplementation on immune parameters in gut failure patients on home parenteral nutrition.

The relationships between some parameters of the immune response and selenium were investigated in five patients receiving home parenteral nutrition for short-bowel syndrome. They were first submitted to a relative depletion by providing 20 micrograms selenium/day as L-selenomethionine for 1 mo. Then, daily selenium intake was raised to 200 micrograms for 2-4 mo. On entering the study, the patients presented a relatively good health status, and immunological parameters were at the lowest limit of the normal range. Four patients rapidly responded to the 200-micrograms supplementation by a continuous increase in their plasma selenium levels, whereas the fifth patient showed a moderate and late increase. At the end of the trial, there was an improvement in the lymphocyte response to pokeweed and phytohemagglutinin mitogens in four patients and to CD3 in three patients. The response to two of three antigens (Candidin, Varidase) tested was also enhanced in the same patients, but the response to the third antigen (tetanus toxoid) was uniformly low in all patients. The only patient showing essentially no immune improvement after selenium supplementation was the one with a low and delayed increase in plasma selenium. This study supports a role for selenium in the maintenance of an optimal immune response in humans.

Aged↗
PubMedDate not supplied

Interference between two immune responses. I.--Modification of the kinetics of the mouse response to SRBC by responses to heterologous RBC.

Influence of a preceding immunization with HoRBC on the immune response to SRBC was studied in Swiss and CBA inbred mice. In Swiss mice, a short interval (1day) between the two immunizations produced an acceleration of anti-SRBC response, while a longer interval (4-7 days) inhibited this response. This was interpreted as manifestations of nonspecific helper and suppressor activities triggered by the previous challenge. At any time of a response, there would exist a variable ratio of these two opposite activities. The helper activity was radiation-resistant while the suppressor one was radiation-sensitive at the time of its appearance and was effective on the IgG as well as on the IgM response. CBA mice response to SRBC was only influenced by the suppressor and not by the helper component of the preceding challenge with HoRBC. These CBA mice were very good responders to this antigen, and this may be the cause of their strain particularities. If we consider that each individual is permanently submitted to natural immunizations, the ratio of the resulting non-specific activities must be esentially variable with time; it can partly account for the individual amplitude variation of an engaged immune response.

Animals↗