Early ultrasonic effects upon mammalian CNS structures (chemical synapses).
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Animals↗
Biomedical subjects
K I Bailey
Publications and source records attributed to K I Bailey.
Ultrasonically induced, in vivo morphological damage in mouse testicular tissue.
Mouse testes were exposed in vivo to 1 MHz continuous wave ultrasonic energy for 30 sec at spatial peak intensities of either 2 or 5 W/cm2. Following exposure they were surgically removed at times ranging from immediate (within 60 sec) to 63 days, and histologically prepared for optical microscopy examination. The observed alterations can be classified according to the number and type of affected cell layers in the tubule. Leydig cells were unaffected, and some alterations differed from those previously seen at higher ultrasonic exposure intensities or at much longer exposure times.
Animals↗
Ultrasonically induced morphological damage to mouse ovaries.
Mouse ovaries were exposed in vivo to 1 MHz continuous wave ultrasonic energy at spatial peak intensities ranging from 5 to 100 W/cm2 for times varying from 300 to 15 s depending on the intensity. Following exposure the ovaries were surgically removed at times ranging from immediately (within 60 s) to 7 days and prepared histologically for light microscopic analysis. The observed tissue alterations varied from severe, at the higher intensities to subtle, at the lower intensities. Lesions were manifested by pyknosis of cells, vacuolization of cells and tissue, eosinophilic cytoplasm, and general cellular disruption. Subtle alterations showed large numbers of polyovular follicles and increases in the amount of PAS positive material in the interstitial tissue. Various ovarian structures showed differing sensitivities to the insult with luteinized structures being preferentially altered.
Animals↗
Ultrasonically induced temperature elevation in mouse ovary.
Temperature increases, resulting from exposure to 1 MHz ultrasound, were measured in in situ and in exteriorized mouse ovaries. It is concluded that temperature increases from exposure to 10 W/cm2 and less are probably not significant for producing ovarian tissue damage, but that 25 W/cm2 exposures, and greater, are of such magnitude that damaging thermal levels ensue. The significance of blood flow in removing ultrasonically generated heat has been observed quantitatively.
Animals↗