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K Inoshita

Publications and source records attributed to K Inoshita.

14 recordsLinked to original sources
PubMed1990

[Distribution of an antimicrobial agent in oral tissues of rabbit. Cefuroxime axetil].

The distribution of cefuroxime (CXM) was examined in NZW rabbits after oral administration at a dose of 20 mg/kg of cefuroxime axetil. CXM was detected in blood, oral tissues (tongue, gingiva, parotid gland, submandibular gland, cervical lymph nodes and lower jaw bone), liver and kidney. The results were analyzed through pharmacokinetic calculation. Ratio of pharmacokinetic parameters in the tissues and those in the serum (free) were as follows: Cmax: 0.26 to 0.62, AUC: 0.70 to 1.53, MRT: 2.6 to 3.0, VRT: 7.7 to 12.2.

Animals↗
PubMed1977

The cold activation of the classical complement pathway: The cause of the differences between plasma and serum complement in liver cirrhosis.

The mechanism responsible for making the differences between plasma and serum complement (CH50) was studied on eight patients with hepatitis-B(s) antigen negative alcoholic liver cirrhosis. CH50 and C4 activities of the sera of all patients were equal to those of the corresponding EDTA-plasma, when sera wre separated after clotting the blood at 37 degrees C. CH50 and C4 activities of the sera, prepared at 21 degrees C or 4 degrees C, from four of eight patients were very low. When serum from one of these four patients was added to normal human serum, C4 activity of the serum mixture markedly decreased at 4 degrees C but not at 37 degrees C. The inactivation of C4 was prevented by adding EDTA or heparin to the serum mixture. These results indicated that very low complement in the sera, prepared at 21 degrees C or 4 degrees C, of the four cases were due to the cold activation of the classical complement pathway.

Cold Temperature↗