Biomedical subjects
K Inoue
Publications and source records attributed to K Inoue.
[Physiological function of alpha-tocopherol transfer protein].
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[Macrophage scavenger receptor class A].
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[A case of pheochromocytoma detected by hypertensive crisis immediately after drip infusion urography].
We report a rare case of a 60-year-old man with a pheochromocytoma detected by a hypertensive crisis immediately after drip infusion urography. The patient initially consulted our hospital complaining of dysuria. He underwent a drip infusion urography and experienced a hypertensive crisis. The next day he was diagnosed with paralytic ileus. An endocrinological examination, abdominal computed tomography and 123I-metaiodobenzyl-guanidine scintigraphy revealed a pheochromocytoma. The tumor mass was removed, and immediately his blood pressure became normal and the paralytic ileus improved; however, temporary postoperative hypoglycemia was seen. Frequent monitoring of his blood glucose and the administration of an appropriate solution of dextrose, both during and after the operation, were recommended.
[A novel Lp(a) assay not affected by apo(a) size polymorphism].
Apo(a), the protein moiety of Lp(a), has size polymorphism that derives from the variable number of K4 type 2 repeats. We have developed three ELISA method with using monoclonal antibodies against the K4 type 2 repeats, the K4 type 5-protease domain, and the K5 protease domain of the apo(a) molecule. The commercial assay kits were correlated with the results from ELISA that utilized a monoclonal antibody against the K4 type 2 but indicated poor correlation with an ELISA method using anti Lp(a) K4 type 5-protease domain monoclonal antibody. Serum Lp(a) values were 1.8-fold overestimated by the commercial assay kits in samples with S4 type of the largest isoform, but our ELISA method in which the apo(a) K4 type 5-protease domain is used as labeled antibody and capture antibody was not affected by size polymorphism.
[Two cases of urinary retention secondary to aseptic meningitis].
We report two rare cases of urinary retention secondary to aseptic meningitis. Case I was in a 13-year-old boy admitted to the pediatric department due to aseptic meningitis. Eight days after his admission, urinary retention developed and cystometry showed atonic bladder. Case 2 was in a 18-year-old woman consulted the urological department with a chief complaint of urinary retention accompanied with high fever, headache and vomiting. The spinal fluid examination and cystometry revealed aseptic meningitis and atonic bladder, respectively. In both cases, the patients were treated with conservative therapy and bladder dysfunction was resolved after a few weeks. Eleven cases of urinary retention secondary to aseptic meningitis have been reported in the previous literature.
[Composition of vascular tree using moving-table MR angiography: development and preliminary clinical experience with a semi-automated program combining stacks of MR angiographic images].
Moving-table MR angiography, combining a contrast enhanced MRA approach with table movement, has recently become available. This technique allows imaging of long, longitudinal anatomical regions of vasculature. We have developed a semi-automated program combining stacks of MRA images obtained from different image stations, and applied it to the reconstruction of vascular trees in twenty-five patients with peripheral arterial occlusive disease. Using this program, continuous vascular trees, extending from the abdominal aorta to lower leg (up to 124 cm), were semi-automatically reconstructed within two minutes from six different projection angles. Extensive vascular lesions were recognized three-dimensionally by moving image display mode.
[Progressive mitral regurgitation which is necessitated the mitral valve replacement after partial left ventriculectomy (Batista procedure): a case report].
The patient is 61-year-old woman who underwent partial left ventriculectomy, (Batista procedure) due to dilated cardiomyopathy and multiple thromboembolism. Although postoperative course was uneventful, she has had clinical symptoms of the left heart failure due to the increased mitral valve regurgitation at the early postoperative period, gradually. Even though mitral valve regurgitation was severe, it was not apt to re-dilatate the left ventricular capacity evaluated by echocardiography. She underwent the mitral valve replacement on the 92nd postoperative day, and was once possible for weaning from cardiopulmonary bypass under the support of IABP. However, she died on the 19th postoperative day caused by sepsis. It is important to evaluate the accurate mitral valve regurgitation preoperatively for Batista procedure. Although there was the mild mitral valve regurgitation, it is essential to repair or replace the mitral valve for Batista procedure.
[Complications].
Transluminal endovascular stent grafts placement has recently been introduced as a promising alternative to surgical treatment of aortic aneurysms, but complications can occur. Mortality, aneurysm rupture, massive microembolization, paraplegia, endoleaks, and graft migration are significant problems associated with endovascular aneurysm repair. An endoleak, defined as persistence of blood flow within the aneurysm sac outside the lumen of the stent graft, is among the most common complications and is a major problem because it may permit aneurysm expansion and rupture. Endoleaks are caused by inadequate hemostatic sealing at the proximal or distal attachment site or by retrograde sac perfusion through patent aortic branch vessels; the reported incidence varies from 10-40%. In the treatment of thoracic aortic aneurysms, the occurrence of paraplegia is considered to be the Achilles heel of this technique, because reconstruction of intercostal arteries is impossible. Coverage of the intercostal artery, which is thought to be important for distal spinal cord blood supply, with stent grafts should be avoided. Although we consider this exciting new technique holds great promise for aortic aneurysm repair, further advances in device technology are necessary to minimize the risk of complications with this procedure.
Prevalence of hip osteoarthritis and acetabular dysplasia in Kamitonda: from a longitudinal population-based epidemiological study of rheumatic diseases in Japan.
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[Myelin basic protein in the cerebrospinal fluid].
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The palmomental reflex elicitation by electrical stimulation of the median nerve.
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Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule.
The purpose of this study was to identify and optimize the antiangiogenic activity of IFN-alpha against human bladder cancer cells growing in the bladder of nude mice. 253J B-V IFN(R) cells (resistant to antiproliferative effects of IFN-alpha or IFN-beta) were implanted into the bladder wall of nude mice. Three days later, the mice were treated with s.c. injections of IFN-alpha (70,000 units/week) at different dosing schedules (1, 2, 3, or 7 times/week). Daily therapy with IFN-alpha produced the most significant inhibition of tumor growth, tumor vascularization, and down-regulation of basic fibroblast growth factor and matrix metalloprotease-9 mRNA and protein expression. Changing dose and schedule of IFN-alpha administration had minimal effects on the expression of vascular endothelial growth factor or interleukin 8. The daily s.c. administrations of 5,000 or 10,000 units IFN-alpha-2a produced maximal inhibition of bFGF and MMP-9 expression (mRNA and protein), maximal reduction in tumor vessel density, and maximal reduction in serum levels of bFGF. Daily administration of higher doses of IFN-alpha failed to produce significant antiangiogenic effects. These data suggest that the antiangiogenic activity of IFN-alpha is dependent on frequent administration of optimal biological dose and not maximal tolerated dose.
[A case of neurofibromatosis with intrathoracic meningocele presenting respiratory failure caused by pleural effusion].
We reported a 58-year-old man with neurofibromatosis and an intrathoracic meningocele. He was admitted to our hospital because of left-sided chest pain and dyspnea on exertion. He presented with severe kyphoscoliosis and showed a round, well circumscribed mass lesion in the paravertebral region of the left upper lung on a chest roentgenogram. Just before admission, pleural effusion accumulated in the left thoracic cavity, which had caused the respiratory symptoms. The mass was diagnosed as an intrathoracic meningocele by MRI and iotrolan CT myelography. The pleural effusion was transudate fluid and no leakage from the meningocele to pleural cavity was demonstrated. Posterolateral extradural approach with laminectomy was done and dural plasty to close the connection between the meningocele and the subarachnoidal space was carried out. After the operation, both the intrathoracic meningocele and the pleural effusion disappeared with remarkable improvement in the respiratory function. Intrathoracic meningocele is known to be seen in association with neurofibromatosis and scoliosis, but it is very rare to see an intrathoracic meningocele which causes respiratory failure due to massive pleural effusion like this report.
Outbreak of acute gastroenteritis caused by human group C rotavirus in a primary school.
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Induction of human gamma delta T cells in myasthenia gravis thymus transplanted SCID mice.
BACKGROUND: TCR-gamma delta cells develop by extrathymic differentiation and might play an important role in thymectomy-resistant myasthenia gravis (MG) patients. In this study, we show development of human TCR-gamma delta cells in periphery of SCID mice by transplantation of human MG thymus or thymoma. METHODS: Three pieces of thymoma tissue and four of non-thymoma thymic tissues were obtained from MG patients by thymectomy. Each tissue was transplanted into 5-6 weeks old female SCID mice by intraperitoneal injection or surgical implantation. Rate of human TCR-positive cell development and its subtypes (TCR-alpha beta, TCR-gamma delta) were measured in the mice blood at one, three, and six weeks after the transplantation. RESULTS: Human TCR-positive cells were detected three weeks after transplantation. Rate of TCR-gamma delta T cell development got higher in thymoma transplanted group than in non-thymoma transplanted group. CONCLUSIONS: We could successfully develop human mature T cells in SCID mice by transplantation of human MG thymus or thymoma.
[Growth hormone (GH, hGH)].
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