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Biomedical subjects

K Ishida

Publications and source records attributed to K Ishida.

At least 19 recordsLinked to original sources
PubMed1979

Experimental hematogenous Candida endophthalmitis: diagnostic approaches.

Anterior chamber aspiration and vitreous aspiration were evaluated as diagnostic procedures for establishing a specific microbiological diagnosis in the rabbit model of hematogenous Candida endophthalmitis. Vitreous aspiration was the most successful procedure, confirming the diagnosis of hematogenous Candida endophthalmitis in 62% of eyes with documented intraocular infection. When animals with only the most severe clinical endophthalmitis were considered, vitreous aspiration confirmed the diagnosis in 89% of eyes evaluated. Vitreous aspiration correlated well with the extent of clinical endophthalmitis, as well as with postmortem, whole-vitreous cultures. Gram staining of the aspirate was additive to culture results in confirming the diagnosis. Anterior chamber aspiration was positive in only 1 of 58 eyes evaluated (1.7%). Additionally, muscle biospy was evaluated in this study as a tool for establishing a microbiological diagnosis in the rabbit model of disseminated candidiasis. Only 2 of 131 biospy specimens contained detectable Candida. Although vitreous aspiration may be associated with ocular complications, in certain clinical settings this procedure may be valuable in establishing the definitive microbiological diagnosis of hematogenous Candida endophthalmitis.

Animals↗
PubMed1978

Malakoplakia of the stomach. Report of a case and review of the literature.

A case of malakoplakia of the stomach associated with well-differentiated adenocarcinoma of the transverse colon was studied by light and electron microscopy. The gross appearance consisted of a slightly elevated plaque with umbilication of the covering mucosa. Histologically, the lesion was composed of submucosal proliferation of histiocytes with the typical cytoplasmic inclusions known as Michaelis-Gutmann bodies. Ultrastructurally, these inclusions had a dense central calcified body and concentric alternating rings. Twenty-four cases of gastrointestinal malakoplakia from the literature, including two cases of gastric malakoplakia, were reviewed.

Adenocarcinoma↗
PubMed1977

Ultrastructure of fibroblasts from the comb of the cockerel.

Fibroblasts in the intermediate layer of comb dermis of intact single combed White Leghorn cocks and testosterone-injected capons, all 82 days of age, were divided into three types, namely A, B and C, according to the ultrastructure of these cells. All the fibroblasts in the same tissue from capons were type C. 2. The Golgi complex and the rough endoplasmic reticulum were well developed in type A and type B fibroblasts. The latter organelle in type A fibroblasts was in the form of long parallel cisternae spaced a uniform distance apart, while that in type B fibroblasts was extremely distended, branched and anastomosed, containing flocculent material in the cisternae. In type C fibroblasts, both the Golgi complex and the rough endoplasmic reticulum were poor.

Animals↗
PubMed1977

Experimental hematogenous endophthalmitis due to Candida: species variation in ocular pathogenicity.

The ocular pathogenicity of species of Candida other than albicans was studied in the rabbit model of hematogenous candida endophthalmitis by injection of 10(5)-10(8) colony-forming units of Candida krusei, Candida parapsilosis, Candida guilliermondii, Candida tropicalis, Candida stellateoidea, and Candida albicans (control). At one and three weeks after infection, rabbits were examined by indirect ophthalmoscopy and were sacrificed for culture of eyes and kidneys. With an inoculum of 10(8) organisms, C. tropicalis and C. stellatoidea infected the kidneys but only occasionally infected the chorioretina and never infected the vitreous. Organisms were cultured only rarely from the kidneys of rabbits infected with C. krusei, C. guilliermondii, and C. parapsilosis; these species were never isolated from eyes. The C. albicans control consistently infected the kidney, chorioretina, and vitreous; approximately equal numbers of C. albicans were isolated from these organs. These data suggest a relative resistance of ocular tissues to hematogenous candida infections with species other than C. albicans.

Animals↗