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Biomedical subjects

K Iu Danilov

Publications and source records attributed to K Iu Danilov.

At least 19 recordsLinked to original sources
PubMed2003

[Early diagnosis of intra-abdominal complications after surgery on the stomach and the duodenum].

Ultrasonic examination early after surgery permits to visualize "zone of surgery", to evaluate stomach, duodenum or their stump, to diagnose motor-evacuatory and purulent-septic complications, to determine policy of their treatment. Dynamic ultrasonic examinations permit to realize daily monitoring of "surgical zone" and timely correction of therapy, to reduce number of x-ray and endoscopic examinations after surgery that leads to improving of treatment results.

Abdomen↗
PubMed1998

[The arteriolymphatic administration of antibiotics in treating patients with suppurative-inflammatory diseases of the abdominal cavity organs].

Experimental study of pharmacokinetics of Gentamicin was carried out in 23 dogs. Three different modes of its intralymphatic administration were used: intranodular inguinal, lymphotropic retroperineal and arterio-lymphatic. It has been established, that arterio-lymphatic mode of introduction of antibiotics (as well as regional endolymphatic and lymphotropic) warrants high concentration of antibiotics in venous blood and lymph. The peculiarity of arteriolymphatic administration is regional effect of accumulation of the antibiotic in organs and tissues of abdominal cavity of corresponding arterial region. Arteriolymphatic infusions of antibiotics have been introduced into complex of drug treatment of patients with pyogenic and inflammatory disorders of abdominal organs. The clinical testing has revealed high curative effect of this made of antibiotics administration.

Animals↗
PubMed1994

[Pharmacokinetic validation of intra-arterial lymphotropic antibiotic therapy of pyo-inflammatory diseases of organs of the peritoneal cavity].

Intraarterial infusion of antibiotics provided a 1.39-2.84-fold regional increase in the antibiotic concentration as compared to that after the intravenous infusion in the organs and tissues of the abdominal cavity affected by an inflammatory process. Regional intraarterial lymphostimulation provided a 1.31-1.64-fold increase in the antibiotic resorption from the affected organs and tissues of the abdominal cavity to the relevant regional lymph nodes. Combined intraarterial administration of the antibiotic and lymphostimulant made it possible to provide high antibiotic concentrations in both the affected organs and tissues of the abdominal cavity and the respective portions of the regional lymphatic system.

Animals↗
PubMed1991

[Intralymphatic antibacterial therapy of acute cholecystitis].

Clinical examination of 34 patients showed that lymphotropic administration of antibiotics creates concentrations in organs and tissues involved in the inflammatory process in acute cholecystitis which are 1.63-14.95 times higher than those produced by intramuscular injection. Study of the course of the clinical picture of the disease in 122 patients with acute destructive cholecystitis revealed the high efficacy of this method of antibiotic therapy: the laboratory indices of the inflammation became normal within a shorter period of time, the inflammatory process in the gallbladder was arrested more rapidly, the number of postoperative complications fell 2.6 times, and the terms of hospital-stay of the patients reduced by 1.3 times. Lymphotropic antibiotic therapy is more pathogenetic in the management of acute destructive cholecystitis.

Acute Disease↗
PubMed1991

[Pharmacokinetics of gentamicin after its regional endolymphatic and lymphotropic administration to dogs].

It was shown that intralymphatic+ inguinal administration of gentamicin provided its high concentrations in central lymph, blood and ++para-aortic lymph nodes and increased the antibiotic levels in the abdominal organs 2.33 to 6.66 times as compared with its intramuscular administration while lymphotropic retroperitoneal administration of gentamicin provided more prolonged maintenance of the antibiotic therapeutic concentrations in lymph of the thoracic lymphatic duct, central blood, ++para-aortic lymph nodes and the abdominal organs in comparison to its intramuscular administration. Intralymphatic+ inguinal administration of drugs providing the highest concentrations in all the organs of the abdominal cavity and the ways of the infection penetration is useful in therapy of severe inflammatory diseases of the abdominal organs inclined to generalization and lymphotropic retroperitoneal administration of drugs is useful in therapy of less severe purulent inflammatory processes in the abdominal cavity.

Animals↗
PubMed1989

[Accumulation of gentamicin in biological fluids, organs and tissues during regional lymphotropic therapy with antibiotics].

Gentamicin distribution in biological fluids, organs and tissues, lymph nodes was studied on 70 dogs. Three administration routes were compared: lymphotropic, intramuscular and regional subcutaneous. The lymphotropic route for the drug administration was recommended not long ago. It was shown that the lymphotropic route provided the antibiotic accumulation mainly in some of the abdominal organs as compared to intramuscular administration. Regional lymphotropic administration of the antibiotic to the experimental animals resulted in higher gentamicin levels in the regional lymph nodes and regional organs as compared to the levels observed after the antibiotic regional subcutaneous administration in the same doses.

Animals↗
PubMed1978

[Mucoectomy in stomach surgery].

Considering the stage character of the formation of the stomach polyps and various patterns of histomorphologic changes the authors suggest to use polypectomy together with mucousectomy. The operation was carried out upon 38 patients with stomach polyps. The technic of mucousectomy combined with bilateral trunk vagotomy for gastric and duodenal ulcer was devised in the experiments on 62 dogs. This operation was carried out upon 7 patients.

Animals↗
PubMedDate not supplied

[The 5-fluorouracil content of the pancreas and parapancreatic tissues when it is administered regionally into the tissue of the round ligament of the liver].

In the experiment on 31 dogs there was shown a significant increase of 5-fluorouracil concentrations in the pancreas and parapancreatic tissues with regional methods of its administration in the fat of the round ligament of the liver. A more prolonged preservation of the drug concentrations at the therapeutic level in the blood was observed. The most effective method of the cytostatic therapy is the regional lymphotropic method.

Animals↗
PubMedDate not supplied

[Changes in the immune system indices of diabetes mellitus patients].

A decrease in the amount of T-lymphocytes and the total amount of lymphocytes in the peripheral blood occurs in diabetes mellitus patients with hyperglycemia over 150 mg%; a decrease in the amount of T-active lymphocytes occurs but in 350 mg% and upwards. A decrease in the amount of B-lymphocytes is noted in hyperglycemia over 200 mg%. The reaction of blast-cell transformation is sharply suppressed in a grave form of diabetes mellitus whereas in moderately grave conditions its decrease is less noticeable. It is assumed that disorder of cellular immunity can be one of the factors contributing to the development of pyoseptic diseases in diabetes mellitus patients.

Adolescent↗
PubMedDate not supplied

[Experimental rationale for the use of intra-arterial lymphostimulation in drug treatment of inflammatory diseases of organs of the peritoneal cavity].

The functional status of regional lymph drainage was studied in 40 rats with various models of pyoinflammatory abdominal diseases. It was shown that intratissue lymphopoiesis and lymph drainage were suppressed in general fecal peritonitis and hemorrhagic pancreonecrosis, which was evident in 1.59-3.15-fold elimination time of the lymphotropic indicator indigo carmine from the tissue and organ depot of the abdomen. The intravenous lymphostimulation with 10% rheomacrodex solution led to 1.06-1.51-fold increases in lymphopoiesis and lymph drainage. Regional intraaortic lymphogenic stimulation caused the most marked changes in the lymph circulatory bed, producing 1.22-1.56-fold effects on lymph drainage of abdominal organs and tissue.

Animals↗