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Biomedical subjects

K J Beck

Publications and source records attributed to K J Beck.

At least 19 recordsLinked to original sources
PubMed1983

[Rare manifestation of an Echinococcus cyst in the female genital tract].

This report deals with the clinical and morphological findings in a rare case of Echinococcus granulosus of the female genital tract. The symptoms are not characteristic. A preoperative diagnosis can only be suspected on serological grounds. The diagnosis is confirmed by histological examination of the specimen. The therapy of choice is the surgical removal of the cyst. Care should be taken not to open the cyst during operation. The success of the operation should be confirmed by postoperative serological, ultrasonic, scintigraphic and x-ray controls.

Adnexal Diseases↗
PubMed1980

Effect of ethinyl estradiol on renin activity and on the concentrations of renin substrate and aldosterone in plasma of ovariectomized women.

The effect of high doses of ethinyl estradiol (0.4 mg/day) on renin substrate concentration, renin activity and aldosterone concentration in plasma was studied in eight ovariectomized women. Plasma renin substrate (angiotensinogen) increased already within 24--48 h, reaching a maximum on the third to fifth day after starting estrogen treatment. Thereafter, renin substrate concentration remained relatively constant in a range which was fourfold above the baseline levels. The increase of plasma renin activity was less pronounced and showed considerable between-patient variability; this increase was statistically significant only after 48 hours of estrogen intake. A rise in plasma aldosterone concentration was observed in two of four subjects examined. In one patient treated with 5 mg estradiol benzoate intramuscularly, plasma renin activity increased without any measurable change in renin substrate concentration. Only in one subject treated with ethinyl estradiol did plasma renin activity increase before plasma renin substrate concentration; the results presented do not preclude factors other than the stimulation of renin substrate synthesis in the liver from contributing to the activation of the renin-aldosterone axis during treatment with ethinyl estradiol.

Aldosterone↗
PubMed1977

[The capacitation of spermatozoa].

Mammalian spermatozoa attain their fertilization capacity only after reaching the female genital tract. This process takes place in several stages. First there is a degradation of inhibitors (decapacitation factor and acrosin inhibitor) in the vagina, cervix and uterus. Concurrent with or subsequent to this process the actual capacitation in the uterus and tubes occurs. Capacitation is characterized by an increase in metabolism, alteration of motility and activation of lytic enzymes of the spermatozoa. The acrosome reaction takes place only on direct contact with the ovum. This reaction is accompanied by morphological changes in the spermatozoon and enables the proteolytic enzymes (corona-penetrating enzyme, acrosin and hyaluronidase) to leave the sperm head. With the help of these enzymes, the spermatozoon is able to break down the various egg envelopes, to penetrate the ovum and initiate fertilization.

Acrosin↗
PubMed1977

[Radiological observations on bone changes in women after bilateral ovariectomy with and without oestrogen prophylaxis (author's transl)].

A retrospective study was carried out on 69 women who had hysterectomies and bilateral ovariectomies carried out during puberty for non-malignant disease. The effect of oestrogen prophylaxis on bones was studied by various radiological methods (1. Miminal combined cortex thickness in the proximal radius according to Meema; 2. Biconcavity index according to Nordin; 3. Osteoporosis stage in the lumbar spine according to Saville; 4. The Singh index in the proximal femur and 5. Absorption coefficient and relative cortical thickness of the phalanges). It was found the the hormone-treated group (33 cases) showed significantly greater bone density than the control group (36 cases). It is therefore suggested that women undergoing ovariectomy before the menopause, or those with low bone density at the natural menopause, should be treated by long-term oestrogen therapy, provided there are no specific contraindications.

Absorptiometry, Photon↗
PubMed1976

Lack of relationship between cyclic nucleotide levels and spermatozoal function in human semen.

Cyclic adenosine 3':5'-monophosphate (cyclic AMP) levels were determined in 103 samples of human semen and grouped according to the number of spermatozoa in the ejaculate. No correlation was found between cyclic AMP concentrations and the number, motility, and morphology of the spermatozoa or the fructose content, pH, and volume of the ejaculate. Similar findings were obtained with cyclic guanosine 3':5'-monophosphate levels in 24 samples of human semen. Therefore, cyclic nucleotide levels in human semen appear to be derived from sources other than spermatozoal adenylyl or guanylyl cyclase.

Cyclic AMP↗
PubMed1976

The effect of steroid hormones on motility and selective migration of X- and Y-bearing human spermatozoa.

Motility and selective migration of X- and Y-bearing human spermatozoa were studied in the presence of physiologic levels of sex steroid hormones (17beta-estradiol; estriol, 0.5 ng/ml; testosterone; progesterone; lynestrenol; and norgestrel, 5 ng/ml) and 200-fold higher concentrations. Estrogens and, to a smaller extent, testosterone accelerated spermatozoal migration, while gestagens had an inhibitory effect. 17beta-Estradiol was most effective in stimulating the motility of human spermatozoa, while norgestrel caused the strongest inhibition of forward movement. Migration of X- and Y-bearing spermatozoa was most significantly altered after longer distances of migration, shown by an increase in the percentage of Y-bearing spermatozoa from 43.7% to 63.3% at a distance of 90 mm. However, prolongation of migration time to 36 hours caused a reduction in the percentage of Y-bearing spermatozoa at the 90-mm distance, from 63.3% to 46%. Specific differential effects of sex steroid hormones on the pattern of selective migration and the distribution of X- and Y-bearing spermatozoa were not observed.

Estradiol↗
PubMed1975

[Donor cervical mucous in the treatment of the persistent cervical factor in infertility (author's transl)].

A case of persistent infertility due to a cervical factor is reported which did not respond to several treatment regimes to make the cervical mucous penetrable for the sperms of the husband. Intra-uterine insemination was equally unsuccessful, however the in-vitro incubation of the semen of the husband in donor cervical mucous and subsequent intra-uterine insemination of this incubated mucous resulted in a pregnancy.

Body Temperature↗