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K J Murthy

Publications and source records attributed to K J Murthy.

33 records · Page 2Linked to original sources
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Hepatic dysfunction in undernourished patients receiving isoniazid and rifampicin.

Adult undernourished tuberculous patients receiving isoniazid, rifampicin and ethambutol were evaluated clinically and biochemically for hepatic dysfunction. The nutritional status was assessed by body-mass index, serum albumin and haemoglobin. While only 11% of the patients developed jaundice, the majority of the patients had a significant elevation of the serum hepatic enzymes suggesting subclinical hepatotoxicity. A significant downward trend during the 3-6 months period was seen in patients with multiple estimations of SGOT and SGPT indicating a self-limiting toxic process. However, the continued elevation of GGT suggests enzyme induction by rifampicin. Undernutrition contributes to drug toxicity by various mechanisms. Therefore, it is important to evaluate the nutritional status of the tuberculous patients receiving drugs, which are potentially hepatotoxic.

Adolescent↗
PubMedDate not supplied

Excretion studies of nitrofurantoin and nitrofurantoin with deglycyrrhizinated liquorice.

Nitrofurantoin and nitrofurantoin with liquorice were given to healthy volunteers and patients suffering from urinary tract infections. The excretion rates of the drug, colony counts and side effects were studied in patients and excretion rates in the volunteers. The excretion rates of the drug were significantly higher in patients receiving the drug with liquorice and also side effects were minimal. There was no significant difference in the excretion rates of the drug with addition of liquorice in healthy volunteers.

Clinical Trials as Topic↗