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Biomedical subjects

K J Price

Publications and source records attributed to K J Price.

25 records · Page 2Linked to original sources
PubMed1993

Hyperthermia induces c-fos expression in the preoptic area.

To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neurons than control or cold-exposed animals. These observations add to the physiologic evidence that neurons of the preoptic area participate in thermoregulation and provide a means to identify the neurotransmitter systems involved.

Animals↗
PubMed1993

Prescribed versus unrestricted carbohydrate diets in children with type 1 diabetes.

The diets of 53 children over 8 years of age with diabetes mellitus were examined by 24 h recall. Thirty-seven had been on prescribed carbohydrate diets while 16 had been on an unrestricted carbohydrate diet since diagnosis. The mean intakes of energy (prescribed 9.1 MJ, unrestricted 9.0 MJ, p = 0.66), carbohydrate (prescribed 259 g, unrestricted 251 g, p = 0.64), fat (prescribed 99.8 g, unrestricted 98.2 g, p = 0.84) and fibre (prescribed 29.2 g, unrestricted 31.0 g, p = 0.42) were not significantly different between the two groups. Both groups showed similar distribution of carbohydrate through the day and considerable day to day variation in their carbohydrate intake (coefficient of variation, prescribed 14.5%, unrestricted 14.1%, p = 0.87). Those on prescribed diet had a mean carbohydrate intake which exceeded their prescription by 36%. Both groups had above average fibre intake suggesting that qualitative advice was being followed. There were no significant differences between the two groups in metabolic control (HbA1 prescribed 12.4%, unrestricted 11.9%, p = 0.23), body mass index (prescribed 19.8 kg m-2, unrestricted 20.4 kg m-2) or insulin dosage (prescribed 1 unit kg-1 day-1, unrestricted 0.9 units kg-1 day-1). This study has shown no differences between prescribed and unrestricted carbohydrate diets. Qualitative, rather than quantitative advice may be more appropriate in the management of Type 1 diabetic children.

Adolescent↗
PubMed1993

Intussusception in preterm infants.

Two cases of intussusception in infants born at 26 and 30 weeks' gestation are described. The two infants presented in the neonatal period with abdominal distension, intolerance of feeds, and rectal bleeding. An initial diagnosis of necrotising enterocolitis was made and the infants were treated medically. This led to a delay in the diagnosis of the intussusception. Published work on neonatal intussusception is reviewed and attention is drawn to the fact that the presenting signs and symptoms can be similar to those of necrotising enterocolitis. A diagnosis of intussusception should therefore be considered in any preterm infant with suspected necrotising enterocolitis.

Anastomosis, Surgical↗
PubMed1982

A prospective trial comparing a silicone elastomer intravenous cannula (Visis) with a polytetrafluoroethylene cannula (Cathlon).

Post-infusion phlebitis remains one of the most frequent causes of hospital morbidity with an incidence varying between 13 and 39 per cent (1-4). A recent study indicated that a silicone elastomer cannula (Visis) had desirable properties (5). We have carried out a prospective trial comparing the value of such a cannula with a Teflon cannula (Cathlon) already in routine use.

Catheterization↗
PubMedDate not supplied

Impaired microvascular hyperaemic response in children with diabetes mellitus.

Clinically detectable microvascular complications of diabetes are uncommon in children with diabetes especially in the prepubertal group. It is unclear whether subtle functional abnormalities of the microcirculation occur in children without evidence of clinical microangiopathy and in particular whether abnormalities can be demonstrated in children before puberty. The maximum hyperaemic response to direct local heating (44 degrees C) of the foot skin was measured by laser Doppler fluximetry in 50 diabetic and 50 non-diabetic children. An impaired hyperaemic response occurred in the diabetic children compared with control children (diabetic 1.25 (95% CI 1.13-1.37) V; control 1.74 (1.60-1.88) V; p less than 0.001) and was significantly related to duration of diabetes but not to long-term blood glucose control. The impaired response was also present in prepubertal diabetic children (diabetic 1.37 (1.16-1.58) V; control 1.89 (1.67-2.12) V; p less than 0.001). Systolic and diastolic blood pressure were significantly raised in the prepubertal diabetic children. These data suggest that a functional abnormality of the microcirculation occurs in children with diabetes in the absence of clinically detectable microangiopathy, and even before puberty.

Adolescent↗