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Biomedical subjects

K J Sheth

Publications and source records attributed to K J Sheth.

46 records · Page 3Linked to original sources
PubMed1976

Pleural dialysis in acute renal failure.

An 80 day old infant developed acute renal failure postoperatively after nephrectomy for Wilm's tumor. Pleural dialysis was utilized to control electrolyte imbalance of acute renal failure. Function of pleura as a dialyzing membrane was evaluated for the clearance of urea and creatinine.

Acute Kidney Injury↗
PubMedDate not supplied

Plasma acidic glycohydrolases in insulin-dependent diabetes mellitus.

We assayed plasma activities of beta-galactosidase, beta-hexosaminidase, alpha-fucosidase and alpha-galactosidase involved in degradation of the glycoprotein molecule in 110 insulin-dependent diabetics aged 3-1/2 to 19 years and compared them to a group of normal youngsters. We correlated the plasma enzyme activities with the duration, control and sequelae of insulin-dependent diabetes. Insulin-dependent diabetics had a significantly higher plasma activity of beta-hexosaminidase and alpha-mannosidase (p less than 0.01) and a significantly lower plasma activity of alpha-fucosidase and alpha-galactosidase (p less than 0.01). Of the 5 enzymes studied, only plasma beta-hexosaminidase correlated with fasting and postprandial blood sugar (p less than 0.01), cholesterol and triglycerides (p less than 0.05). Additionally, poor control of diabetes was also associated with a significantly higher plasma beta-hexosaminidase activity (p less than 0.01). Proteinuria or an abnormal Addis count suggestive of renal involvement was associated with various changes in plasma acidic hydrolases. These changes may be related to insulin deficiency rather than hyperglycemia and may be genetically determined.

Adolescent↗
PubMedDate not supplied

Urinary acidic glycohydrolases as an index of kidney damage in juvenile diabetes mellitus.

Two lysosomal glycohydrolases, beta-galactosidase and beta-N-hexosaminidase which have been associated with kidney disease were measured in the urine of 110 youngsters with juvenile diabetes mellitus. The mean enzyme excretions in the diabetic group were intermediate between those of normal youngsters and those with active renal disease. Three youngsters with known kidney disease had elevations comparable to others in the diabetic group but no direct correlation could be shown between enzyme elevations and proteinuria or Addis count abnormalities. Positive correlations were seen between enzyme levels and indices of metabolic balance including blood sugar, cholesterol and triglycerides but not with urine sugar or ketones. Duration and estimated stage and control of diabetes also correlated with the urinary enzymes. These preliminary studies are consistent with the possibility that the excretion of these enzymes reflects the ongoing renal damage which occurs in most juvenile diabetics.

Adolescent↗
PubMedDate not supplied

Prediction of intra ocular lens power in 100 patients using the ophthasonic a scan unit.

The aim of this study was to determine the range of ametropias encountered by using the computerized Ophthasonic A-Scan. The SRK formula was used to compute the IOL power using axial length and keratometry as inputs. The accuracy of prediction of IOL power was calculated by noting the disparity between the expected post-operative refraction and the actual refraction obtained after one and a half months of IOL implantation. The results obtained were encouraging; the maximum deviation from the expected result being +/- 3.2 D.

Adult↗
PubMedDate not supplied

Failure of fresh frozen plasma infusions to alter the course of hemolytic uremic syndrome.

The hemolytic uremic syndrome (HUS) is characterized by thrombocytopenia, anemia, and acute renal failure. Fresh frozen plasma (FFP) infusions have been claimed to shorten the course of HUS. However, no long-term follow-up is available. Hence, we analyzed the effects of FFP infusions on acute resolution and long-term sequelae of HUS in 12 children (5 boys, 7 girls, mean age 4.5 years, range 7 months to 9 years) and compared to a historical control group of 31 children (13 boys, 18 girls, mean age 3 years, range 8 months to 9 years). The patient population, severity of HUS, and other modes of therapy except FFP were similar in the two groups. There was no statistically significant difference between the groups in the acute resolution of HUS as evaluated by recovery of anemia, thrombocytopenia, and return of renal functions. Long-term sequelae of HUS such as hypertension, end-stage renal disease, and CNS residual abnormalities were also similar in two groups. One child died in the FFP group and 2 children died in the control group. We feel that FFP infusions have no significant effect on the course of HUS and its use should be questioned.

Blood Transfusion↗
PubMedDate not supplied

Hemolytic uremic syndrome associated with Corynebacterium diphtheria infection.

Although hemolytic uremic syndrome (HUS) is usually idiopathic, it follows a number of infections. The pathogenesis of post-infectious HUS is endothelial cell damage by either circulating endotoxin or exotoxin. Diphtheria exotoxin has never been implicated in HUS. We report HUS following diphtheria infection in a 9 yr old un-immunized white female admitted with a short history of sorethroat and thrombocytopenia. There were hemorrhages in sclera, gums and left tonsillar area and a grayish exudate on right tonsil. Laboratory values revealed Hgb 14.4 g/dl, decreasing to 7.6 g/dl, WBC/26,900 mm3, platelet count 7,000/mm3. Bone marrow examination revealed normal megakaryocytes. She was oliguric with BUN 214 mg/dl, serum creatinine 12.4 mg/dl and serum uric acid 19.2 mg/dl. Despite peritoneal dialysis, red cell and platelet transfusions and exchange transfusion she expired. A postmortem examination was refused. A throat culture done on admission grew corynebacterium species which was later confirmed to be toxigenic C. diphtheriae. Diphtheria exotoxin inactivates an enzyme in cytoplasm which is necessary for peptide chain elongation. This may have interfered with prostacyclin synthesis thereby allowing the development of HUS.

Blood Transfusion↗