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Biomedical subjects

K J Singh

Publications and source records attributed to K J Singh.

15 recordsLinked to original sources
PubMed1998

Spider angiomas are not found in the retina of patients with cirrhosis.

To determine the prevalence of spider angiomata in patients with cirrhosis, the factors influencing them and whether or not they are present in the retina of patients with cirrhosis, 93 cirrhotics were studied. Cutaneous spider angioma were seen in 19 (20%) patients. All patients with spiders had at least one episode of variceal bleeding and had grade III or IV oesophageal varices. Spiders were seen more commonly in patients with alcoholic cirrhosis than in those with non-alcoholic cirrhosis (53.5% vs 6%, p < 0.001), in patients with Child's C cirrhosis than those with Child's A and B cirrhosis (67% vs 4%, p < 0.001). However, although spiders were seen more often in patients undergoing sclerotherapy than those not, the difference was statistically not significant (23% vs 19%, p = NS). Spiders had no association with presence or absence of portal hypertensive gastropathy or gastric varices. None of the patients showed any abnormality or presence of spiders in the retina. It is concluded that spider angiomas are seen more commonly in patients with alcoholic cirrhosis, those with more severe liver disease and patients having large oesophageal varices and they are not seen in the retina of patients with cirrhosis.

Adult↗
PubMed1997

Visual evoked responses in ethambutol induced optic neuritis.

Pattern evoked responses were recorded in 46 patients of tuberculosis on ethambutol and 16 healthy subjects. Deterioration in visual acuity was documented in two patients (4.3%). P100 latency was delayed in 16 cases (34.8%), while in 12 patients (26.1%) both latency and amplitude were affected. A cut off latency value of > or = 140 ms was associated with ophthalmological findings. The incidence of subclinical toxicity as detected by visual evoked response (VER) was higher in older subjects, patients on higher doses of ethambutol (> or = 20 mg/kg/day) and longer duration of treatment. Of two cases with objective ocular signs, one who reported for follow up after two months had recovered completely after stopping ethambutol. Recording of VER is an extremely useful objective test for subclinical optic nerve damage.

Adolescent↗
PubMed1993

Inhibition of nitric oxide limits infarct size in the in situ rabbit heart.

Recent data has suggested a dual role for nitric oxide (NO) so that it can both attenuate myocardial injury during ischaemia and reperfusion as well as mediate reperfusion injury. In this study in the in situ rabbit heart, we have shown that pretreatment with intravenous NG-nitro-L-arginine methyl ester (L-NAME, an inhibitor of NO synthesis) significantly reduced infarct size following sustained coronary artery occlusion and reperfusion. L-NAME was also noted to increase myocardial lactate concentration. This study provides further evidence that protection against ischaemia-reperfusion injury can be derived from manipulation of the microcirculation.

Analysis of Variance↗
PubMed1989

Maternal and neonatal anthropometric and hematological parameters in Manipuri population.

One hundred and sixty five women admitted in the Regional Medical College Hospital, Manipur, for delivery and their newborns were studied for some anthropometric and hematological parameters. The mean weights of mothers and infants were 50.94 +/- 0.86 kg and 2.86 +/- 0.07 kg, respectively. The mean hemoglobin levels were 11.05 +/- 1.57 g/dl in mothers and 15.05 +/- 0.27 g/dl in cord blood. Statistically no correlation existed between hemoglobin levels and between weights of mothers and infants.

Adolescent↗
PubMedDate not supplied

Hysteroplasty and vaginoplasty for reconstruction of the uterus.

A simple surgical procedure for reconstruction of the uterus from available Müllerian bulbs with simultaneous vaginoplasty is described. The Müllerian bulbs on both sides are incised, and suitable central fibromuscular tissue is excised to make a uterine cavity. The margins are sutured around a uterine mold, taking care to leave tubal os free. The reconstructed lower end of the uterus (now representing the cervix and upper third of the vagina) is brought down into the space already made out of the peritoneal septum between the bladder and the rectoanal region. The perineal operation for vaginoplasty is completed after suturing the lower end of the reconstructed uterus to the upper margin of the reconstructed vagina. The vaginal and uterine molds are kept in place for one and two weeks postoperatively, respectively.

Female↗
PubMedDate not supplied

Influence of education and occupation on knowledge about diabetes control.

BACKGROUND: A global epidemic of diabetes has been predicted during the first quarter of the twenty-first century, with a substantial increase in its prevalence in India. Good management of diabetes is a necessary step towards its control and blood glucose testing forms an integral part of this. This study was undertaken to assess the importance of education and occupation in relation to knowledge about good control of diabetes. METHODS: Perception patterns regarding methods for testing blood glucose and metabolic control were assessed by the direct interview method in 793 patients with type 2 diabetes. Patients' knowledge levels were compared for different educational and occupational categories using the Normal test (z-test) and the Student's t-test. RESULTS: The difference between the mean ages of men and women diabetics was not significant (p > 0.1). It was found that 46.7% of the subjects were aware of the importance of blood glucose testing. Awareness regarding the importance of microalbuminuria, lipid profile and glycosylated haemoglobin was observed in 24.1%, 15.5% and 7.6% of patients, respectively. A positive impact of education on overall knowledge levels was observed. However, no definite relationship was found between knowledge and occupation. CONCLUSION: There was a total lack of knowledge regarding self-care of diabetes in all educational and occupational categories (including patients who were qualified doctors). This calls for an urgent need to create greater public awareness. This study may serve as a guideline for developing an educational package for different subsections of the community.

Blood Glucose↗