Biomedical subjects

K J Vikterlöf

Publications and source records attributed to K J Vikterlöf.

At least 19 recordsLinked to original sources

PubMed1988

Olsalazine does not increase the bile acid losses in subjects with a permanent ileostomy.

Olsalazine is a novel compound presently under development for the treatment of ulcerative colitis. Olsalazine sometimes causes diarrhoea; one of the possible explanations could be an increased load of bile acids in the colon. Bile acid ileostomy output was therefore measured enzymatically and after oral administration of tauro-23-[75Se]selena-25-homocholic acid (SeHCAT) in eight subjects during intake of placebo or olsalazine. The bile acid output showed great individual variations during both treatment periods, but there was no indication that olsalazine interfered with bile acid handling in the terminal ileum.

Adult↗

PubMed1980

Serial bone scanning in the evaluation of stage and clinical course in carcinoma of the prostate.

Bone scanning with 99mTc-EHDP or 99mTc-MDP was compared with skeletal X-ray survey, determination of acid phosphatase levels and clinical symptoms in a consecutive series of 176 patients with prostatic carcinoma. Skeletal metastases were present in 24%. In these metastatic cases 27% had negative radiographics at the time of initial diagnosis, 29% had normal serum acid phosphatase values and 74% had symptoms other than skeletal, which dominated the clinical picture. When bone scanning was negative for metastases such lesions were never detected in the radiographs. Hence, bone scanning was sufficient for the initial diagnosis of skeletal metastases in 55% of cases. When scans were judged as equivocal or positive an X-ray survey should be done. The variations in count density in metastatic disease were followed by visual assessment of serial bone scans. A densitometric method for quantification of the variations was developed as an aid in the evaluation. Serial bone scanning using a quantitative method appears to offer a readily available objective index of early therapeutic response for use in general clinical practice as well as in controlled therapeutic trails.

Acid Phosphatase↗

PubMed1979

The value of whole body bone scan in the pre-operative assessment in carcinoma of the breast.

In 126 patients with primary breast cancer a patient moving whole body bone scan was performed when they first presented. None of the patients in stage I had an evidence of skeletal metastases. Two patients (3%) of 62 in stage II and 4 patients (17%) in stage III had evidence of skeletal metastases. It appears that whole body scanning is the most accurate, sensitive and convenient method of detecting osseous metastases and of staging breast cancer. This investigation should be carried out pre-operatively. Detection of early asymptomatic bony metastases will provide a better planning of treatment with rational approach.

Bone Neoplasms↗

PubMed1979

Efficiency of postoperative radiation in carcinoma of the breast. A comparison between two methods.

The results of simple mastectomy and postoperative irradiation of the chest wall and the regional lymph nodes in a series of 256 patients with primary carcinoma of the breast (between 1970 and 1972) were compared with those in a series of 155 patients (from 1963 to 1965) treated with radical mastectomy and postoperative irradiation of the regional lymph nodes. A statistically significant difference (p less than 0.01) was found between the chest wall recurrences in the group of patients with irradiation of the chest wall and the group without. No evidence indicates that routine postoperative irradiation should be harmful. Distant metastases in the 1970--1972 group were less frequent (13%) than in the 1963--1965 group (29%)9 The age-corrected 4-year survival rates for stages I and II were 83 per cent for the 1970--1972 group and 78 for the 1963--1965 group. The age-corrected 10-year survival rates for states I and II were 60 per cent.

Age Factors↗

PubMed1978

Acute skin reactions in postoperative breast cancer patients receiving radiotherapy plus adjuvant chemotherapy.

A group of 26 patients with operable carcinoma of the breast received postoperative radiotherapy plus adjuvant chemotherapy. Acute skin reactions were studied by clinical observation. There was a statistically significant difference (P less than .01) in the acute skin reactions in the chest wall area in those who received chemotherapy (81%) compared to the controls who received only radiotherapy (33%). Acute skin reactions began at the completion of postoperative radiotherapy and reached maximum severity 1-2 weeks later. They usually subsided after 4-6 weeks. No skin reactions were observed in the parasternal, supraclavicular fossa, or axillary regions. On the basis of these findings, postoperative radiotherapy combined with adjuvant chemotherapy is probably beneficial.

Breast Neoplasms↗

PubMed1976