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Biomedical subjects

K Jaeger

Publications and source records attributed to K Jaeger.

At least 19 recordsLinked to original sources
PubMed1992

[Histomorphologic findings in human expanded tissue].

Forty biopsies from 22 patients undergoing tissue expansion were examined histologically. Expanded skin demonstrated a generally unconspicious morphology of the epidermis, dermis and subcutis. Adnexal organs of the skin were preserved. Mean epidermal thickness was increased to 710 +/- 240 microns compared to 624 +/- 215 microns in the controls. The tissue expanders were bordered by a richly vascularized connective tissue capsule with a very variable mean thickness of 795 +/- 712 microns. These histologic findings in human tissues support experimental evidence for a real increase in tissue by expansion.

Adolescent↗
PubMed1991

Regulation of postprandial mesenteric blood flow in humans: evidence for a cholinergic nervous reflex.

Duplex ultrasound was used to investigate superior mesenteric artery haemodynamics in humans in order to determine the physiological importance of postprandial blood concentrations of cholecystokinin octapeptide (CCK8), gastrin 17, secretin, and glucagon and to study whether a nervous cholinergic reflex mechanism has a role in the postprandial mesenteric blood flow response. Duplex parameters of vessel diameter, mean velocity, and flow volume were determined serially in the basal state and after stimulation. Changes were compared with baseline values. Superior mesenteric artery parameters were significantly increased over baseline values after a liquid test meal, but ingestion of saline did not cause any changes. Hormones infused simultaneously at postprandial concentrations did not change mesenteric blood flow. When they were infused at pharmacological doses, however, a significant increase in flow parameters was observed. Pretreatment with atropine significantly (p less than 0.05) reduced the mesenteric blood flow response to meal stimulation (57%). These data suggest that the four hormones tested are not of quantitative importance in regulating postprandial superior mesenteric artery blood flow. A cholinergic nervous reflex, however, participates in the control of food induced mesenteric artery flow changes.

Adult↗
PubMed1991

[Characteristic contributions of the venous duplex exam].

The major advantage of non invasive duplex scanning is the ability to combine its imaging capability (information on the morphology) with the possibility to detect Doppler spectra (hemodynamic information) of the visualised segment. This new method, mainly used for the investigation of arterial diseases, is more and more applied in phlebology too. The technique is very reliable in the diagnosis of deep vein thrombosis and in the investigation of varicose veins and their junctions with the deep venous system. In these indications duplex scanning is likely to become a standard technique. The use of duplex in phlebology, however, should not be limited to these indications. In this paper the results of some special phlebologic duplex studies are presented: A) changes in the subclavian vein induced by pace maker electrodes; B) utility in the differential diagnosis of deep vein thrombosis; C) efficacy in the control of caval filter; D) measurements of physiologic venous hemodynamics and quantification of phlebologic drug effects.

Humans↗
PubMed1990

The creation of a small bowel pouch by tissue expansion--an experimental study in pigs.

Tissue expanders (inflatable silicone balloons) were implanted into a bypassed ileum segment of seven pigs and consecutively filled over 8 to 12 weeks. The mean increase of the volume of the small bowel loops was 12 fold with a maximum of 22.8 times the original volume. The final volume 9 weeks after expander removal still presented an increase of 500%. Histologically there was an increase of the thickness of all layers of the bowel wall, especially in the tunica muscularis. The mucosa showed a value above normal in mean in vitro 14C-resorption capacity per surface area in the reintegrated bowel. Possible clinical applications of the augmentation of the gut by expansion as a rectum substitute after proctocolectomy, as a urinary bladder or stomach substitute, and for the treatment of short bowel syndrome are discussed.

Animals↗
PubMed1990

Intraluminal cyclosporine A reduces capsular thickness around silicone implants in rats.

One theory of the cause of connective tissue capsule formation around silicone mammary prostheses is based on an immunological interaction. In an in vitro pilot study, it is shown that intraluminal cyclosporine A, a potent T-lymphocyte-specific immunosuppressive agent, can diffuse slowly through the outer shell of a standard double-lumen silicone breast implant. Round silicone tissue expanders containing 50 mg of cyclosporine A were implanted subcutaneously in 10 rats. Ten animals served as controls. Evaluation was performed after three months. A significant decrease in collagen capsular thickness of 21.6 +/- 5.4 microns (mean +/- standard deviation was measured histomorphometrically in the treated group compared with 39.6 +/- 8.6 microns in the control group (p less than 0.001).

Animals↗
PubMed1990

Chronic myeloproliferative disorders: prognostic importance of new working classification.

Variants of chronic myeloproliferative disorders (CMPD) were compared according to their clinical features and classified by bone marrow biopsy appearances. Subsequently, this classification was further evaluated using survival data and histological variables from iliac crest biopsy specimens of an additional 1391 patients, making a total of 2241 patients available for analysis of outcome. The patients were grouped again into three main classes: "typical"; "variant"; and "transformed". "Typical" comprised the "classic" groups. "Variant" included the less uniform myeloproliferative syndromes, distinguished also by more variable clinical features, a different prognosis, and a greater tendency to fibrotic and blastic transformation. "Transformed" defined the end stages of both "typical" and "variant" types. Ten subgroups were distinguished by different histology and prognosis. Particular prognostic importance was assigned to atypia and immaturity of haemopoiesis, predominance of individual haemopoietic cell line, number and anomalies of megakaryocytes and progressive fibrosis. It is suggested that the proposed subclassification would be helpful for studies of epidemiology and therapeutic trials by allowing more homogeneous groups to be recognised.

Bone Marrow↗
PubMed1989

[Results of the treatment of hepatic echinococcosis by hydatectomy].

In 72 patients with hydatid disease results and complications of different operation techniques are compared. Whereas we previously preferred pericystectomy and resecting methods we now perform irrigation and drainage in hydatid cysts of the liver. By use of a simple, flexible instrument even poorly accessible cysts can be transferred to irrigation and drainage therapy. Results of this procedure are good. The complication rate was decreased.

Adolescent↗
PubMed1989

Failed tissue expansion in a patient with osteogenesis imperfecta.

This is a report of a failure of tissue expansion in a 43-year-old patient suffering from a mild form of osteogenesis imperfecta tarda. Filling of the expander was not possible. Skin histology showed thrombosis of the blood vessels and vessel wall necrosis. This finding supports the theory that tissue expansion does not depend as much on mechanical skin laxity as on the proliferative potential of the skin.

Adult↗
PubMed1989

The influence of the calcium channel blocker nimodipine on flap survival.

The calcium channel blocker nimodipine has been used successfully in neurological patients for the treatment of vasospasm after subarachnoid hemorrhage and stroke. In this study of experimental random pattern skin flaps in rats, an increase of nearly 50% in the survival rate to 94.33% (+/- 7.3% standard deviation) under nimodipine treatment versus 66.00% (+/- 16.5% standard deviation) in the controls could be demonstrated (p less than 0.001). Vital dye injections in a separate experiment indicated that the increased flap survival is mainly due to improved microcirculation. The distance traveled by the dye was 8.01 +/- 1.21 cm in the experimental versus 6.61 +/- 1.25 cm in the control group (p less than 0.05).

Animals↗
PubMed1989

[The incidence of recurrent laryngeal nerve paralysis following thyroid surgery].

We examined the histories of 789 thyroid resections for the influence of the type of disease and the kind of operative procedure on the frequency of recurrent laryngeal nerve lesions. In operations for benign goiter the amount of recurrent nerve palsy was 1.8%, in cases of recurrent symptomatic goiter it was 9.5%. In cases of total thyroidectomy for carcinoma it was 10% (7.9% when related to the number of nerves that could be damaged). By literature review and own results a dissection of the recurrent nerves usually does not seem to offer any advantages.

Adolescent↗
PubMed1979

[Biopsy of para-aortic lymphnodes in patients with malignant lymphomas (author's transl)].

In treatment of malignant lymphomas exploratory laparotomy with splenectomy, liver and lymphnodes biopsy is necessary in order to individualize appropriate management. The surgeon must make maximal effort to obtain lymphnodes for histological examination. The surgical anatomy of the retroperitoneum in space of abdominal aorta and the biopsy procedure of paraaortic lymphnodes were described. The literature was reviewed.

Biopsy↗