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Biomedical subjects

K Jarczok

Publications and source records attributed to K Jarczok.

At least 19 recordsLinked to original sources
PubMed1989

[Transcutaneous stimulation of the heart ventricles: its effectiveness, comfort during the examination and new diagnostic possibility].

An attempt of assessment of transcutaneous cardiac pacing tolerance in healthy volunteers was carried out as well as abilities of this method utilization for examination of retrograde atrioventricular conduction. Ventricles were paced through highohm electrodes positioned on the chest wall with simultaneous recordings of transoesophageal ecg at the level of the left atrium and the sphygmogram of the right common corotid artery. Pacing perception threshold, skeletal muscle stimulation threshold, cardiac pacing threshold, algesic and myo-respiratory threshold of examination tolerance were estimated. Effective ventricular pacing within the range of stimulation tolerance was obtained in 10 of 15 patients (67%). Mean ventricular pacing threshold was higher than pacing perception and skeletal muscles stimulation thresholds (42 mA; 9.4 mA and 20.2 mA). Ventricular pacing threshold was lower than algesic and muscles thresholds of examination tolerance (60-70 mA) warranting relatively good tolerance of transcutaneous cardiac ventricular pacing. In 8 of 10 persons with effective ventricular stimulation retrograde a-v nodal conduction was stated which proved that transcutaneous cardiac ventricular stimulation can be used for noninvasive assessment of retrograde a-v nodal conduction.

Adult↗
PubMed1987

Breast and subcutaneous plasmoblastic infiltrations in the course of plasmoblastoma.

In two female patients aged 37 and 66 y breast and subcutaneous plasmoblastic infiltrations developed in the course of therapy for plasmoblastoma. In the first patient with plasmoblastic leukemia those infiltrations occurred after 6-month therapy. In the second patient progression of the disease was noted after 30 months of treatment. Both multiple osteolytic lesions as well as breast and subcutaneous plasmoblastic infiltrations were noticed that time. Multidrug treatment programme had little influence on those infiltrations.

Adult↗
PubMed1987

Primary gastric lymphoma. A survey of 7 cases.

Clinical characteristics and response to therapy of 7 patients with primary non-Hodgkin's lymphoma of the stomach and 1 patient with double malignancy are analysed. All patients but one were gastrectomized and subjected to the chemotherapy (COP, CHOP or leukeran + prednison) programme. In 3 patients (2 with lymphocytic lymphoma and 1 with lymphoplasmocytic lymphoma) no recurrence occurred in the course of the observation time ranging from 18 to 20 months. In one patient with centrocytic lymphoma extra-abdominal recurrence was successfully treated with leukeran + prednison. 4 patients (2 with immunoblastic lymphoma and 1 with lymphoplasmocytic lymphoma) with abdominal or extra-abdominal recurrence died after a period ranging from 4 to 29 months despite more aggressive therapy with CHOP programme. Opinions concerning pathogenesis and treatment strategy of those lymphomas are presented too.

Adult↗
PubMed1985

Lymphoblastic lymphoma in a female with chronic granulocytic leukaemia.

In a 18 years old, Ph1 negative woman a lymphoblastic lymphoma developed after 16 months of treatment for juvenile form of CGL. In the course of the disease we observed twice the myeloblastic transformation and once the low differentiated transformation of CGL. Based on available methods we are not in a position to exclude a particular form of lymphoblastic transformation of CGL involving lymph nodes without leukaemic blood picture.

Adolescent↗
PubMed1985

Fractional administration of adriblastin and modified route of ara-C administration for the treatment of acute leukaemia.

Two groups of AML patients (n1 = 63, n2 = 20) and two groups of ALL patients (n1 = 33, n2 = 15) were treated using polychemotherapy protocols which in each leukaemia subtype differed mainly in adriblastin administration being either in bolus form (30 mg/m2/day i.v.) or fractional form at the beginning 20 mg i.v., then 6 mg/m2 every 6 h. The fractional method of administration was elaborated on experimental data indicating the superiority of continuous infusion of anthracyclines. In AML additional ara-C was given in continuous infusion only on 1 to 3 days, on 4 to 8 days duplicated dose was administered subcutaneously (i.e. 100 mg/m2 every 12 h). In patients given fractional doses of adriblastin and in AML also ara-C in the modified way the statistical analysis revealed a higher CR (ALL - 67%/93%, AML - 46%/60%) and CR + PR rates, a lower rate of infections as the cause of death in the AML group, lower rates of nausea and vomiting as well a lower increase of infections in the course of the induction treatment in the AML group. Another advantage was a lower total dose of adriblastin for remission induction treatment as well as an elevated cumulative dose which allows anthracyclines to be longer used. The efficacy of the modified ara-C administration confirms our earlier observation.

Acute Disease↗
PubMed1985

Diagnostic and prognostic value of the terminal deoxynucleotidyl transferase (TdT) activity in treating the blastic phase (bp) of chronic granulocytic leukaemia (CGL).

The blastic cell phenotypes of 26 cases of CGL in blastic phase were estimated and the patients were treated with different schemes. The following methods of typisation of the blast cells were used: cytochemical stainings (POX, Sudan B, PAS, nonspecific esterase), estimation of TdT activity, and in 11 patients the testing with monoclonal antibodies of VI series. Using these methods 10 patients (38%) with lymphoid form of the blastic phase, 11 (43%) with the myeloid type and 5 patients (19%) with undifferentiated type were diagnosed. In the group of lymphoblastic type a longer survival time and complete remissions were observed. High TdT activity in blastic cells did correspond with favourable response to Vincristin and Prednison. The introduction of TdT assessment into the diagnosis of CGL allows the cells to be classified more precisely, thus helping in defining the prognosis and in the choice of treatment programme.

Adolescent↗