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K Jonasson

Publications and source records attributed to K Jonasson.

5 recordsLinked to original sources
PubMed1995

The influence of the Gyne-T 380S IUD on menstrual blood loss and iron status.

The influence of the Gyne-T 380S intrauterine contraceptive device (IUD) on menstrual blood loss (MBL) and iron status (hemoglobin, hematocrit, red cell count and indices, and serum ferritin) was evaluated. MBL was determined objectively by the alkaline hematin method in 18 women (mean age 37.1 +/- 1.6 yr, range 22-46 yr) before and 3, 6 and 12 months after insertion of a Gyne-T 380S IUD. MBL prior to IUD insertion was 59 +/- 8 ml and increased to 91 +/- 11 ml (p < 0.01) 3 months after insertion. MBL then remained largely unchanged during the remainder of the observation period (6 months, 94 +/- 12 ml; 12 months, 92 +/- 13 ml). The percentage increase in MBL at the respective measurement points ranged between 54 and 59% which is comparable with previous reports regarding the increase in MBL associated with the use of a copper IUD. There were no significant changes recorded in iron status parameters during the 12-month observation period following IUD insertion. Based on the results of the present study, women from developed countries apparently tolerate an increased MBL of approximately 55% without developing iron deficiency anemia. Iron stores were unchanged indicating an adequate adaptive increase in intestinal iron absorption.

Adult↗
PubMed1993

The long-term effects of copper surface area on menstrual blood loss and iron status in women fitted with an IUD.

The long-term effects of copper surface area on menstrual blood loss (MBL) and iron status (hemoglobin, hematocrit, red cell count and indices, and serum ferritin) were evaluated in 25 healthy women who were observed for a period of 3 years following insertion of an intrauterine device. MBL was determined objectively by the alkaline hematin method. The women (mean age 37.2 +/- 1.6 yr, range 27-46 yr) were fitted with a Multiload intrauterine device (IUD) with a copper surface area of either 250 mm2 (MLCu-250, n = 13) or 375 mm2 (MLCu-375, n = 12). MBL prior to IUD insertion was 55 +/- 8 ml for women subsequently fitted with a MLCu-250 and 59 +/- 9 ml for women fitted with a MLCu-375. An increase in MBL was recorded at all measurement points following IUD insertion (MLCu-250/MLCu-375: 3 months: 55/49%; 6 months: 58/49%; 12 months: 64/41%; 24 months: 55/49%; 36 months: 47/39%, NS). There were no significant differences in iron status parameters before IUD insertion between groups nor were there any significant changes recorded in any of these parameters after IUD insertion. Our findings that the increase in copper surface area from 250 mm2 to 375 mm2 had no effect on MBL were thus substantiated by the hematological findings. Based on the results of the present study, women from developed countries apparently tolerate an increased MBL of approximately 45% without developing anemia. Iron stores were unchanged indicating an adequate adaptive increase in intestinal iron absorption.

Adult↗
PubMedDate not supplied

Anti-sperm IgA antibodies against the equatorial segment of the human spermatozoon are associated with impaired sperm penetration and subfertility.

OBJECTIVE: To determine the prevalence of antibodies directed against the equatorial segment of the spermatozoon in (a) serum in both sexes in relation to age and fertility status and (b) semen of infertile men with tail-to-tail sperm agglutination in relation to in vitro sperm penetration capacity. MATERIAL: Serum samples were obtained from 30 neonates, 11 prepubertal children, 30 adolescents, 60 adults aged 20-50 years, and 60 adults over the age of 70. Semen samples were obtained from 62 men with normal sperm counts and sperm morphology but with tail-to-tail agglutination. METHODS: Sperm antibodies were demonstrated with an immunoperoxidase assay. Sperm penetration capacity was measured with a modified Kremer capillary test. RESULTS: Serum anti-sperm antibodies were absent in children but appeared in teen-age boy (10%) and in adult men (20%) and women (30%). Lower prevalence of serum anti-sperm antibodies was noted for old individuals of both sexes (6-10%). Among individuals with a history of infertility, a significantly higher frequency of anti-sperm antibody-positive men (P < .001) and (P < .05) was found as compared to fertile controls. Presence of IgA antibodies bound to the equatorial segment of spermatozoa was associated with impaired in vitro sperm penetration capacity. No IgG or IgM anti-sperm antibodies bound to the equatorial segment were demonstrable. CONCLUSIONS: Seminal IgA antibodies bound to sperm are associated with impaired sperm penetration.

Adolescent↗