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Biomedical subjects

K Jonsson

Publications and source records attributed to K Jonsson.

At least 163 records · Page 9Linked to original sources
PubMed1982

Vincristine, Adriamycin, cyclophosphamide, and etoposide (VP16-213) in small-cell anaplastic carcinoma of the lung.

Twelve patients with small-cell anaplastic carcinoma of the lung were treated with vincristine 1 mg/m2 i.v. day 1, adriamycin 50 mg/M2 i.v. day 1, cyclophosphamide 1,000 mg/m2 i.v. day 1, and etoposide 80 mg/m2 i.v. day 2, 4, 6 given on an outpatient basis and repeated at 3-week intervals. As consolidation therapy seven patients received two courses of BCNU median 29 mg/m2 (range 24-73 mg/m2) short term intraarterial infusion in the bronchial artery with 2 to 3-weeks intervals. One patient with limited disease had no evidence of disease for 13+ months and one patient complete remission for 3+ months. Four of ten patients with extensive disease had complete remission for median 5 months (range 2+ to 5+ months) and four patients had partial remission for median 5 months (range 4 to 5+ months). Despite side effects the chemotherapy was well tolerated by the patients. The results correspond to those obtained with other effective regimens in small-cell anaplastic carcinoma of the lung.

Adult↗
PubMed1982

Preoperative angiography in patients with bone metastases.

Angiography was performed before a stabilizing operation in 4 patients with bone metastases to the femur or pelvis. In 2 patients the tumor was embolized with pieces of Spongostan before resection and in 2 the angiographic finding excluded resection and only nailing was performed. If resection is planned angiography and embolization should be performed in order to decrease blood loss during surgery.

Adenocarcinoma↗
PubMed1982

Intravenous arteriography in the preoperative evaluation of advanced atherosclerosis.

Intravenous arteriography may be used as an alternative to translumbar or transaxillary angiography in cases with occlusion or severe stenosis of the aorta or iliac arteries, to determine the extension of the disease. During a 10-year period the method was used in 117 patients. For the examination, 80 to 100 ml of contrast medium was injected into the right atrium and after a delay of 10 to 20 seconds the lumbar aorta, iliac and femoral arteries were demonstrated. The quality of the examination was excellent or good in 92 per cent. No complications occurred. In 19 patients a continuous pressure recording was made in the main pulmonary artery. The pulmonary artery pressure increased to a significantly higher degree after contrast medium injection than after injection of the same amount of isotone saline. In all patients the pressure returned to normal within 4 minutes.

Adult↗
PubMed1982

Hepatic telangiectasia in Osler's disease treated with arterial embolization. Report of 2 cases.

Hepatic hereditary telangiectasia in 2 females was treated with hepatic artery embolization. In one patient both peripheral and central arterial occlusion was performed; the patient died of massive gastro-intestinal bleeding for 2 months later. Autopsy showed extensive regions with necrosis in the right liver lobe. In the next patient only central occlusion of the right hepatic artery was performed and the arterio-venous shunting in the left liver lobe left remaining. After a long reconvalescence period the patient recovered completely. It is advocated to centrally occlude only that hepatic artery supplying the most affected parts of the liver in Osler's disease. Thus extensive necrosis with possible ensuing death may be avoided.

Adult↗
PubMed1982

The clinical significance of lympho-venous anastomoses in malignant disease.

Pedal lymphangiography has revealed lympho-venous anastomoses (LVA) in 62 patients with malignant disease. The LVAs were caused by obstruction of lymph flow and the obstruction was secondary to surgery in 23 patients, abnormal lymph nodes in 16 and a combination of surgery and abnormal nodes in 14. In 16 patients the LVA led to portal radicals giving opacification of the liver. Chest X-ray examination was normal in 41 patients. In 5 patients the initial chest examination was normal, but lung metastases or widening of the mediastinum developed 1-5 years later. Twelve patients had lung metastases or widening of the mediastinum at the time of the diagnosis of LVA. Clinical follow-up was available in 47 patients, of whom 30 died 1-60 months after diagnosis of LVA. It is concluded that the prognosis of a patient with LVA is poor, provided the cause is not a negative lymph dissection or an unrelated surgical procedure. In patients with pathological lymph nodes the presence of LVA indicate an advanced involvement. Relatively few patients with LVA had or developed lung metastases indicating that the biology of the tumor and the patient is more important than LVA to develop lung metastases.

Adult↗
PubMed1981

Toxic epidermal injury following intraarterial adriamycin treatment.

Toxic epidermal injury was induced in the right forearm and thumb of a 74-year-old woman following two courses of 28 mg/m2 Adriamycin infused in the brachial artery with a three-week interval. The toxic epidermal injury was treated with a wet dressing solution and a neomycin cream without corticoids; it healed in one month. Afterwards the woman received 22 courses of Adriamycin intravenously or intraarterially in 5.5 or 11 mg/m2 doses, but the toxic epidermal injury did not occur.

Brachial Artery↗
PubMed1981

Double blood supply of bronchogenic carcinoma from multiple arteries.

Angiography was performed in connection with intra-arterial chemotherapy in 110 patients with bronchogenic carcinoma. All tumors were supplied from at least one ipsilateral bronchial artery. A double systemic arterial supply was found in 12 patients, the additional blood supply coming from a second ipsilateral bronchial artery in 3 patients, from the ipsilateral internal mammary artery in 4, from intercostal arteries in 4 and from the subclavian artery in one patient. All patients with tumor supply from a non-bronchial artery had direct tumor spread to the chest wall or to the mediastinum. A complete angiographic examination may therefore be of prognostic significance and necessary before intra-arterial chemotherapy, which mainly has a local effect.

Adult↗
PubMed1981

Malignant hemangioendothelioma of metacarpal bones.

Malignant hemangioendothelioma is a tumour of vascular origin with wide distribution in various organs and tissues of the body. However, it is seldom localized primarily in bone. In this report our experience with a case of primary multifocal malignant hemangioendothelioma of the metacarpal bones is reported. Because of the focal pattern of malignancy excisional biopsy failed to give the diagnosis which was not established until the tumour was radically removed.

Adult↗
PubMed1981

Hemangioma of the lunate (Klippel-Trénaunay syndrome). Case report.

An intraosseous hemangioma of the lunate was diagnosed as the cause of wrist complaints. At angiography considerable arteriovenous shunting within the bone was shown. Replacement of the lunate by a SILASTIC implant relieved the pain. The intraosseous hemangioma, however, appeared to be only a part of more wide-spread disease which fulfilled the criteria for a Klippel-Trénaunay syndrome.

Adult↗
PubMed1981

Kinins in relation to renin activity in renal and inferior caval veins in normal individuals and patients with primary aldosteronism.

Blood kinin concentration and plasma renin activity (PRA) were determined in the renal veins and in the inferior caval vein (ICV) below the level of the renal veins in 9 normal individuals (5 men and 4 women) and 7 patients with primary aldosteronism (3 men and 4 women). PRA in the renal veins and ICV was significantly lower and plasma aldosterone concentration in ICV significantly higher in the patients as compared to the normals. Kinin concentration in the renal veins and ICV did not differ significantly between the patients and the normals (0.31 +/- 0.04 (mean +/- SEM) vs 0.45 +/- 0.03 and 0.27 +/- 0.05 vs 0.45 +/- 0.06 microgram/l, respectively). In the normal individuals kinin concentration and PRA were inversely related in the left renal vein (r = -0.80; P less than 0.02), whereas this relation did not reach statistical significance in the right renal vein (r = -0.60; P less than 0.10). Kinin concentration in both renal veins was positively correlated to kinin concentration in ICV (r = 0.73; P less than 0.05 and r = 0.83; P less than 0.02 for the right and left renal vein, respectively). These results indicate that intrarenal kinin formation and renin release are inversely related in normal subjects. Furthermore, they suggest that one and the same enzyme, possibly renal kallikrein, may be implicated in the kinin formation in the systemic as well as in the renal circulation. Intrarenal kinin formation seems not to be increased in primary aldosteronism.

Adult↗
PubMed1980

Angiography of the ovarian artery in adnexal lesions.

Selective catheterization of the ovarian artery was performed in 39 women with pelvic tumor. Previously the combination of ultrasound and bilateral selective internal iliac angiography was proven to be valuable in the evaluation of gynecologic lesions. The present series demonstrates that selective ovarian angiography still enhances the possibilities for a correct preoperative diagnosis.

Adult↗
PubMed1980

Percutaneous internal drainage in obstructive jaundice.

In eight patients with inoperable obstructive jaundice, an endoprosthesis was inserted percutaneously through the obstruction to allow internal drainage of bile to the bowel. The method offers several advantages over external percutaneous drainage and is warranted in selected cases.

Aged↗