Cancerization of phyllodes tumour.
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Breast Neoplasms↗
Biomedical subjects
K K Deodhar
Publications and source records attributed to K K Deodhar.
Reactive oxygen species involvement in ricin-induced thyroid toxicity in rat.
Ricin is known to have diverse effects on the cells of different organs like liver, kidney, pancreas, intestines and parathyroid. Acute decrease in serum thyroid hormone level 24 h after ricin administration (1.5 micrograms/100 g) led us to suspect the toxic action of ricin on the thyroid. We monitored the lipid peroxidation (LP) and anti-oxidant status of the thyroid tissue to determine the role, if any, played by reactive oxygen species (ROS) in this pathology. An increase of 39% in LP and 47% in superoxide dismutase, along with a 8.5% decrease in catalase points to the imbalance in the antioxidant defence involving hydrogen peroxide and its univalent reduction product, the hydroxyl radical. Thyroid histopathology shows destruction of thyroid follicles and necrosis, which may be due to ROS and may partly explain the 50% reduction in circulating thyroid hormones seen after ricin administration.
Animals↗
Malignant interstitial (Leydig) cell tumour of the testis--a case report.
Interstitial (Leydig) cell tumour of the testis is an extremely uncommon tumour. We report one such tumour displaying histologic features of malignancy--large size capsular invasion and moderate nuclear pleomorphism in an adult male. The tumour also showed crystalloids of Reinke, confirming Leydig cell origin.
Cell Nucleus↗
Spontaneously occurring liver cell adenoma in an adult male.
Spontaneously occurring liver cell adenoma is an extremely rare event. One such tumour in an adult male which was resected surgically is reported here.
Adenoma, Liver Cell↗
Animal model for liver dysfunction using lomustine in Wistar rats.
AIM: To induce intrahepatic cholestasis in rats using lomustine 1(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU). METHODS: Doses of 10 mg, 20 mg and 30 mg/Kg body weight of CCNU were injected intraperitoneally in separate groups of animals. RESULTS: With 10 mg/Kg body weight of CCNU, serum bilirubin levels increased for up to 72 hours and then slowly returned to normal. With a dose of 20 mg/Kg body weight of CCNU, serum bilirubin, AST, ALT and alkaline phosphatase levels increased for 72 hours and then returned to normal over 4-5 weeks. With a dose of 30 mg/Kg body weight peak levels of serum bilirubin were reached on day 17. Pathological studies were carried out after injection of 30 mg/Kg body weight of CCNU. After 72 hours hepatocytes were normal, with minimal nonspecific inflammation and bile duct proliferation. After 16 days, triaditis was observed with deposition of collagen. Focal fibrosis was also noticed. There was no significant abnormality of hepatocytes. After 75 days, hepatocytes showed focal ballooning. Bile duct proliferation was seen invading the parenchyma. Nodules of hepatocytes separated by irregular fibrous bands indicated cirrhosis. CONCLUSIONS: An animal model of intrahepatic cholestasis has been developed using CCNU; this model may be used to assess the utility of hepatobiliary radiopharmaceuticals.
Animals↗