Biomedical subjects

K K Gyi

Publications and source records attributed to K K Gyi.

2 recordsLinked to original sources

PubMed1998

A comparative study of intervention methods (full, partial and non-integration) on late case detection and treatment irregularity in Yangon, Myanmar.

The high percentage (20%) of new cases with grade 2 disabilities, and a low treatment regularity of 47% indicated problems in case detection and case holding in Urban Yangon. The fact that Urban Health Centers (UHCs) were not involved in leprosy control programme might have had an adverse influence. To compare the effectiveness of two methods of integration (full and partial) of urban leprosy services in terms of early case detection and regularity of treatment this study was conducted, in an urban area. Two townships with similar leprosy prevalence, staff infrastructure, socio-economic status, transport, communication and working capacity of the Township Medical Officers (TMOs) were chosen for this intervention study: UHC-A(Thingangyun) for full integration and UHC-B(Tamwe) for partial integration and the remaining 14 townships as non-integrated areas served by the Central Special Skin Clinic (CSSC). This study has shown that it was possible to fully integrate Leprosy Control Programme (LCP) into the Urban Health Centres [Basic Health Services (BHS)] in Urban Yangon. Case detection could be improved by active case finding such as contact examination and school examination conducted by the personnel of UHCs. Treatment regularity was found to be directly proportional to prompt defaulter retrieval action and the motivational level of the TMO and peripheral BHS workers. There were more complaints from patients (8.1%) treated at UHC-A when compared to CSSC (6.7%). Among defaulters there were more adults than children, more males than females and more PB than MB patients.

Humans↗

PubMed1983

Histopathology and host response associated with reduced tumorigenicity of 5-bromodeoxyuridine--treated murine melanoma cells.

Growth of B16 murine melanoma cells (clone B559) with low concentrations of 5-bromodeoxyuridine (BrdUrd) has previously been shown to have little effect upon cell proliferation in culture but to significantly reduce the tumorigenicity of the cells when they are injected into adult syngeneic mice. To determine the fate of BrdUrd-grown cells in vivo, we compared the sites of injection of control, fully tumorigenic B559 cells, and BrdUrd-grown cells (3 micrograms/ml for 3 days, termed 3BRM cells) with greatly reduced tumorigenicity (only 8%). We found no evidence of even a transitory period of progressive growth in vivo of BrdUrd-grown cells. At sites of injection of 3BRM cells, as early as Day 1 after injection, there was a significantly lower proliferation rate of the melanoma cells, significantly greater numbers of infiltrating host mononuclear cells, and a significantly higher ratio of host mononuclear to melanoma cells. There was no evidence of endothelial cell proliferation or neovascularization at the sites of 3BRM cells. When sites of injection at 1 day after injection were examined electron-microscopically, evidence of host melanoma cell interactions was more frequently observed at sites of 3BRM cells. The results suggest that the reduced tumorigenicity of BrdUrd-grown melanoma cells may be due to cytostatic and/or cytotoxic influences generated by an enhanced mononuclear cell response. Because the host response occurs so quickly, the involvement of natural killer cells is postulated.

Animals↗