Biomedical subjects

K K Himsl

Publications and source records attributed to K K Himsl.

3 recordsLinked to original sources

PubMed1994

[A coherent radiotherapeutic-surgical approach, based on PSA, for the management of cancer of the prostate].

The presence of cancer of the prostate does not mean that a patient will succumb to the disease. In fact, prior to the advent of prostate-specific antigen (PSA) testing, the cause of death in 50% of men with detectable extraglandular cancer was intercurrent disease. No studies have conclusively demonstrated a definitive benefit of surgery or radiation over simple observation; therefore treatment complications must absolutely be restricted to a bare minimum while demonstrating curative effect. This review presents a balanced perspective on the management of prostate cancer which results from non-adversarial, extensive, and continuous interactions between two very active Departments (Urology and Radiation Oncology). Such a multidisciplinary approach fosters relevant research projects and ultimately benefits patient care.

Aged↗

PubMed1993

Stimulated reactive oxygen species generation in the spermatozoa of infertile men.

To investigate the possible similarities between the reactive oxygen generating systems of the leukocyte and the spermatozoa, and to identify possible biochemical differences between fertile and infertile patients, the effect of various stimulants on the production of reactive oxygen in fertile, fertile with varicocele and infertile patients was examined. Generation of reactive oxygen species by human spermatozoa was examined in 2 patient groups: a fertile group (14), which included 7 patients with a palpable varicocele, and an infertile group (16) composed of 7 patients with a palpable varicocele and 9 who remained infertile 6 months to 3 years (mean 20 months) after internal spermatic vein ligation. Various known stimulants of reactive oxygen generation in leukocytes were used to assess spermatozoal reactive oxygen production. Reactive oxygen species generation was measured by the technique of chemiluminescence. In the infertile group reactive oxygen generation was markedly increased by the calcium ionophore A23187 and the chemoattractants N-formyl-methionyl-leucyl-phenylalanine and complement 5a (p < 0.05). In addition, fertile patients with varicoceles showed significantly enhanced chemoattractant stimulated reactive oxygen generation compared to fertile donors without varicoceles. This finding of a biochemical alteration in the sperm of infertile patients and patients with varicoceles may lend support to the argument for early varicocele repair.

Adult↗

PubMed1991

Pediatric urinary incontinence.

A clear understanding of the current concepts, pathophysiology, and typical symptoms of voiding dysfunction and pure nocturnal enuresis usually allows the clinician to distinguish these troublesome but benign problems from true underlying pathological conditions of the urinary tract. If a careful history confirms that wetting is the only symptom, and the pattern of wetting is consistent with uninhibited bladder contractions, or if the wetting occurs only during sleep, initial empiric treatment rather than invasive investigation is our preference. On the other hand, if the wetting is associated with infection or persistent dysuria, or if the history or pattern of wetting is suggestive of anatomic or neurogenic causes, a complete investigation of the urinary tract is necessary prior to initiating therapy.

Child↗