Biomedical subjects

K K Ibsen

Publications and source records attributed to K K Ibsen.

At least 19 recordsLinked to original sources

PubMed2001

Social influences and low leisure-time physical activity in young Danish adults.

BACKGROUND: Many youths and adults maintain a sedentary life style and a better understanding of the factors which influence physical activity is needed. This study analyses the association between social factors and low leisure-time physical activity in young adults. METHODS: Three hundred and seventeen children aged 6-18 years participated in a health survey in 1979 and again 13 years later. In this cohort the influence of family factors during childhood on the subsequent risk of low leisure-time activity was analysed using multiple logistic regression. RESULTS: Young women were significantly less physically active during leisure time if over 25 years of age, poorly educated and smokers. In multivariate analysis, childhood smoking was the only variable significantly related to low leisure-time physical activity (OR = 5.6 and 95% CI: 1.4-23.6) in young women. In young men, low leisure-time physical activity was associated with parental work activity. Men whose parents had reported high physical activity during work at the examination in 1976-1978 were less often physically inactive during leisure time (OR = 0.2 and 95% CI: 0.1-0.6) at the follow-up in 1992. CONCLUSIONS: Young smoking girls seem to be a key group in the prevention of both smoking and a sedentary life style.

Adolescent↗

PubMed2000

Comparison of a partially hydrolyzed infant formula with two extensively hydrolyzed formulas for allergy prevention: a prospective, randomized study.

The aim of this study was to compare the allergy-preventive effect of a partially hydrolyzed formula with two extensively hydrolyzed formulas, in infants with a high risk for development of allergic disease. High-risk infants from four Danish centres were included in the period from June 1994 to July 1995. Five-hundred and ninety-five high-risk infants were identified. High-risk infants were defined as having biparental atopy, or a single atopic first-degree relative combined with cord blood immunoglobulin E (IgE)> or =0.3 kU/l. At birth all infants were randomized to one of three different blinded formulas. All mothers had unrestricted diets during pregnancy and lactation and were encouraged to breast-feed exclusively. If breast-feeding was insufficient, one of the three formulas, according to randomization, was given during the first 4 months. It was recommended not to introduce cow's milk, cow's milk products. and solid foods until the age of 4 months. After the age of 4 months a normal unrestricted diet and conventional cow's milk-based formula were given when needed. All infants were followed-up prospectively with interview and physical examination at the age of 6, 12, and 18 months, and if any possible atopic symptoms were reported. If food allergy was suspected, controlled elimination/challenge procedures were performed in a hospital setting. Of 550 infants included in the study, 514 were seen at all visits and 36 were excluded owing to noncompliance. Of 478 infants who completed the study, 232 were exclusively breast-fed, 79 received an extensively hydrolyzed casein formula (Nutramigen), 82 an extensively hydrolyzed whey formula (Profylac), and 85 a partially hydrolyzed whey formula (Nan HA), during the first 4 months of life. These four groups were identical in regard to atopic predisposition, cord blood IgE, birthplace, and gender. Exclusively breast-fed children were exposed less to tobacco smoke and pets at home and belonged to higher social classes, whereas the three formula groups were identical concerning environmental factors. The frequency of breast-feeding was high; only eight (2%) children were not breast-fed at all. The three formula groups were identical in regard to duration of breast-feeding and age at introduction of formula and solid foods. No significant differences were found in the three groups of infants receiving formula milk regarding the cumulative incidence of atopic dermatitis or respiratory symptoms. The cumulative incidence of parental-reported cow's milk allergy was significantly higher in children fed partially hydrolyzed formula (Nan HA) compared with extensively hydrolyzed formula (Nutramigen or Profylac) at 12 and 18 months (NanHA, 7.1%; Nutramigen, 2.5%; Profylac, 0%; p=0.033). The cumulative incidence of confirmed cow's milk allergy was 1.3% (three of 232) in exclusively breast-fed infants, 0.6% (one of 161) in infants fed extensively hydrolyzed formula (Nutramigen or Profylac), and 4.7%(four of 85) in infants fed partially hydrolyzed formula (Nan HA). Partially hydrolyzed formula was found to be less effective than extensively hydrolyzed formula in preventing cow's milk allergy, 0.6% vs. 4.7% (p=0.05), but because of the small number of cases the results should be interpreted with caution. Compared with other similar studies the frequency ofatopic symptoms was low, even though the dietetic intervention did not include either maternal diet during lactation or dietary restrictions to the children after the age of 4 months.

Breast Feeding↗

PubMed1996

[Smoking as social heritage. Children whose mothers are smokers are more likely to become smokers as adults].

Effective prevention of smoking depends on the identification of factors that determine smoking onset. We examined the influence of family factors during childhood (household income, parent education and smoking behaviour) on the subsequent risk of smoking in young adults. In 1979, 1300 children aged 6-18 years, whose parents were randomly selected for participation in the Copenhagen City Heart Study were invited to a health examination. Information about health and smoking behaviour was obtained from 73% of the children. A random sample of 579 of the children were invited to a follow-up examination 13 years later. Four hundred and eighty-six (84%) participated in the follow-up. The influence of household income, parent smoking behaviour and education on the child's risk of becoming a smoker in young adulthood was estimated. Household income and parent education did not significantly affect the risk of adult smoking. Maternal smoking during childhood increased the risk in comparison with the mother being a non-smoker (Adjusted Odds Ratio 1.95 (95% CI 1.07-3.58). Maternal smoking during childhood increases children's risk of becoming young adult smokers, independent of age and smoking behaviour in childhood, gender and social background. In Denmark 28% of smoking in young adults could be attributed to maternal smoking.

Adolescent↗

PubMed1996

Association of body mass index, blood pressure and serum levels of triglycerides and high-density lipoprotein cholesterol in childhood with the insulin sensitivity index in young adulthood: a 13-year follow-up.

BACKGROUND: Tracking of body mass index (BMI), blood pressure and serum lipids from childhood to adulthood has been demonstrated in previous studies. Whether these factors are associated with the insulin-sensitivity index measured in young adulthood (ISIadult) remains undetermined. OBJECTIVES: To determine whether any association exists between the ISIadult and BMI, blood pressure and plasma lipids measured in childhood (1979). METHODS: The study included 227 unrelated white subjects (aged 18-32 years). Their ISIadult were measured in 1992/93 with a combined intravenous glucose (0.3 gl/kg body weight) and tolbutamide (3 mg/kg body weight) tolerance test. BMI, blood pressure and blood lipids were measured in 1979 and again in 1992/93. RESULTS: In men, plasma high-density lipoprotein cholesterol (HDLC) in 1979 (rs = 0.25, F = 0.006) was positively associated with ISIadult and plasma triglyceride measured in 1979 (rs = -0.34, P = 0.001). BMI (rs = -0.29, P = 0.002) and systolic blood pressure, both measured in 1979 (rs = -0.29, P = 0.002) were associated negatively with ISIadult. In women, plasma HDLC measured in 1979 was associated positively and significantly with ISIadult (rs = 0.21, P = 0.024) and BMI measured in 1979 was associated significantly and negatively with ISIadult (rs = -0.22, P = 0.018). Plasma triglyceride or systolic blood pressure, both measured in 1979, were not associated with ISIadult. In gender-stratified multiple-regression analyses [controlling for waist circumference(adult) maximal aerobic capacity (VO2max(adult)), age and women's use of oral contraceptives], plasma HDLC measured in 1979 was associated significantly with ISIadult in men (P = 0.026) but not in women (P = 0.066). A negative association was found between plasma triglyceride measured in 1979 and ISIadult (P = 0.045) in men, but not in women (P = 0.30). BMI, total cholesterol and systolic and diastolic blood pressure, all measured in 1979, were not associated with ISIadult. CONCLUSION: Low plasma HDLC, high plasma triglyceride and high BMI in childhood are associated with low insulin-sensitivity index values in young adulthood.

Adolescent↗

PubMed1995

Maternal smoking during childhood and increased risk of smoking in young adulthood.

BACKGROUND: Effective prevention of smoking depends on the identification of factors that determine smoking onset. We examined the influence of family factors during childhood (household income, parents' education and smoking behaviour) on the subsequent risk of smoking in young adults. METHODS: In 1979, 1300 children aged 6-18 years, whose parents were randomly selected for participation in the Copenhagen City Heart Study were invited to a health examination. Information about health and smoking behaviour was obtained from 73% of the children. A random sample of 579 of the children were invited to a follow-up examination 13 years later. In all, 486 (84%) participated in the follow-up. RESULTS: The influence of household income, parents' smoking behaviour and education on the child's risk of becoming a smoker in young adulthood was estimated. Household income and parents' education did not significantly affect the risk of adult smoking. Maternal smoking during childhood increased the risk in comparison with the mother being a non-smoker (adjusted odds ratio = 1.95; 95% confidence interval: 1.07-3.58). CONCLUSION: Maternal smoking during childhood increases children's risk of becoming young adult smokers, independent of age and smoking behaviour in childhood, gender and social background. In Denmark 28% of smoking in young adults could be attributed to maternal smoking.

Adolescent↗

PubMed1995

The etiology of hypertension in nonrenovascular unilateral renal disease--two cases of renin induced hypertension in congenital renal dysplasia.

We report two cases of severe hypertension and unilateral renal dysplasia. No renal artery stenosis and no other urogenital malformations were found. In both cases we found substantially enhanced secretion of renin from the dysplastic kidney. After nephrectomy both patients obtained a distinctive and permanent reduction or normalization of blood pressure. In the two cases reported, regional renin release induced by ischemia is a very likely etiological factor.

Adult↗

PubMed1994

Relationship between blood pressure and urinary albumin excretion rate in young Danish type 1 diabetic patients: comparison to non-diabetic children. Danish Study Group of Diabetes in Childhood.

In 1989 a nation-wide investigation of blood pressure and urinary albumin excretion rate (AER) was carried out in 506 boys and 441 girls with Type 1 diabetes (approximately 80% of total) treated at 22 paediatric departments. In addition a reference population from 1979 consisting of 663 healthy non-diabetic children (334 boys, 329 girls) served as a control group with respect to blood pressure and body mass index. Microalbuminuria was defined as AER of 20-150 micrograms min-1 in at least two out of three timed overnight urine collections and was diagnosed in 30 adolescents (16 boys, 14 girls). Five patients (3 boys, 2 girls) had overt proteinuria (AER: > 150 micrograms min-1). Age-related percentile charts based on one blood pressure reading were provided for normoalbuminuric diabetic patients and the healthy control group. The study revealed an increase in arterial blood pressure during the period of the pubertal growth spurt for the diabetic and non-diabetic group. The changes were most pronounced for systolic blood pressure. No statistically significant difference was observed in systolic and diastolic blood pressure between normoalbuminuric diabetic children and healthy control children. However, diabetic females aged 15-18 years had significantly higher diastolic blood pressure (75 +/- 1 mmHg, n = 139, mean +/- SE) than healthy control females (72 +/- 1 mmHg, n = 155, p < 0.01), and significantly (p < 0.001) higher body mass index (diabetic females: 22.3 +/- 0.2 kg m-2 vs healthy females: 20.9 +/- 0.2 kg m-2, mean +/- SE.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1994

Serum ferritin in children and adolescents. Results from population surveys in 1979 and 1986 comprising 1312 individuals.

Iron stores were assessed by measurement of serum ferritin in a population survey comprising 436 randomly selected urban Danish schoolchildren (219 boys, 217 girls) 7 to 17 years old. Median ferritin values were similar in boys and girls 7 to 13 years old, while 14- to 17-year-old boys had significantly higher values than girls of similar age (p < 0.0001). Boys had stable median ferritin values from 7 to 15 years of age, after which a significant rise was found from 16 to 17 years of age (p < 0.01). Girls had unchanged median ferritin values from 7 to 11 years of age, after which a significant decrease was found from 12 to 17 years of age (p < 0.01). The frequencies of low ferritin values < 16 micrograms/l (indicating absent iron stores) were: Children 7 to 11 years, 1.0%. Boys 12 to 15 years, 4.5%; 16 to 17 years, 0%. Girls 12 to 15 years, 7.6%; 16 to 17 years, 16.7%. Ferritin levels in the reported 1986 survey were significantly higher than those obtained in a similar survey in the same area in 1979. The results indicate an overall increase in iron stores in Danish schoolchildren and adolescents during 1979-1986, possibly due to an increase in the consumption of meat, and in the use of vitamin-mineral supplements containing iron.

Adolescent↗

PubMed1991

Blood pressure in childhood: pooled findings of six European studies.

In an attempt to study and prevent the development of hypertension, there is a growing interest in measuring blood pressure in children. The aim of this is to detect and monitor those with a relatively high level of blood pressure. Until now, reference values on blood pressure in children are based on data from North-American youngsters. The present study provides percentile charts based on pooled data from studies on blood pressure conducted in six North-West European countries among 28,043 children. These blood pressure centiles are presented as age-, height- and gender-specific. Brief guidelines for blood pressure measurements in childhood and for detection of children with a relatively high blood pressure are included.

Adolescent↗

PubMed1990

[Optic nerve atrophy with particular attention to perinatal damage].

We reviewed the records of children born between 1983 and 1987 reported to the Danish National Register for the Visually Impaired Children and with a diagnosis of optic atrophy. Known or presumed etiology was found in 53 of 55 children. Perinatal stress factors were found in 32 patients (58%), with prematurity, low birth-weight and perinatal asphyxia as the most common findings. 78% of the children in the perinatal damage group were boys. We found that all children with optic atrophy caused by perinatal difficulties had one or more additional handicap. The types of handicaps were cerebral palsy, epilepsy and psychomotor retardation. The importance of paying attention to the fact that multiply handicapped children may be visually impaired on account of optic atrophy is emphasized. Early diagnosis is important in order to start educational stimulation as early as possible. It is concluded that visual impairment caused by perinatal damage to some extent is preventable. The strategy for prevention should be based upon better identification of specific etiologies as well as a better understanding of the pathogenesis of infantile optic neuropathy.

Abnormalities, Multiple↗

PubMed1990

A nation-wide cross-sectional study of urinary albumin excretion rate, arterial blood pressure and blood glucose control in Danish children with type 1 diabetes mellitus. Danish Study Group of Diabetes in Childhood.

Nation-wide screening for microalbuminuria in Denmark was performed in 22 paediatric departments treating children with Type 1 diabetes. Over a period of 6 months 1020 children (less than or equal to 12 years) and adolescents (greater than 12 to 19 years) were screened (81% of total). Of these, 957 (94%) performed at least two timed overnight urine collections. In 209 non-diabetic subjects the upper 95% limit for normal albumin excretion rate (AER) was 20 micrograms min-1. Mean overnight AER was significantly (p less than 0.001) elevated in diabetic (3.0 x/divided by 2.3 (SD tolerance factor) micrograms min-1) and in non-diabetic (2.5 x/divided by 2.2 micrograms min-1) adolescents compared with diabetic (1.7 x/divided by 2.1 micrograms min-1) and non-diabetic (1.3 x/divided by 2.2 micrograms min-1) children. In the diabetic patients AER was positively correlated with the body surface area and age. Among the patients with Type 1 diabetes, 4.3% (18 males and 23 females) had AER greater than 20 to 150 micrograms min-1 (persistent microalbuminuria). A further 7 adolescents (0.7%) had overt proteinuria (greater than 150 micrograms min-1). Clinical data for the 41 diabetic patients with AER greater than 20 to 150 micrograms min-1 were compared with those for 569 diabetic adolescents with AER less than or equal to 20 micrograms min-1 and duration of diabetes more than 2 years. The group with AER greater than 20 to 150 micrograms min-1 had significantly higher mean age (16.5 years) than the group with AER less than or equal to 20 micrograms min-1 (15.0 years; p less than 0.001). Females with AER greater than 20 to 150 micrograms min-1 had significantly higher mean HbA1c level (10.8 +/- 1.9%) than those with AER less than or equal to 20 micrograms min-1 (9.8 +/- 1.9%, p less than 0.003); they also had impaired linear growth (standard deviation score -0.25 vs + 0.16; p = 0.003). These associations were not found in males. Mean body mass index (BMI) was significantly increased in both females (22.2 +/- 2.9 kg m-2) and males (20.8 +/- 2.7 kg m-2) with AER greater than 20 to 150 micrograms min-1, compared with diabetic patients with AER less than or equal to 20 micrograms min-1 (females 20.8 +/- 3.0 kg m-2, p = 0.02; males 19.7 +/- 2.4 kg m-2, p less than 0.006).(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗

PubMed1989

[Body height in a population of children in Greater Copenhagen 7 to 18 years of age in 1981 and 1985. The Osterbro child study].

As part of the childrens' section of the Osterbro investigation, a quantity of standard health information concerning 736 boys and girls in 1981 and 892 in 1985 was collected. Review of these values revealed a significantly greater average height (greater than 3 cm) for boys in the age group 8-16 years and for girls aged 7-15 years than in previously published materials. The final height at about the age of 18 years for both girls and boys was not found to deviate significantly from previous results. The height/weight relationship remained unchanged. Current adjustments of the normal curves for childrens' growth should be made and/or an assessment of how well the subpopulation concerned is in agreement with the national average.

Adolescent↗

PubMed1989

[Food composition and serum lipids in children].

The composition of the diet is considered to be one of the factors which may be of significance in development of ischaemic heart disease. In order to investigate whether the composition of the diet has a greater influence on the cholesterol levels in children than in adults, af 24-hour dietary interview was carried out on 42 children aged 7-11 years who had previously been examined in the childrens' section of the Osterbro investigation. The children were selected in three groups with low, average and high serum cholesterol levels, respectively. The dietary content of energy-providing substances was compared with the cholesterol values measured. In addition, the composition of the diet in other respects was described and was found to contain, on an average, 40% fat, 14% protein and 42% carbohydrate (of which 14% was sugar). The cholesterol intake was 146 mg/1,000 Kcal. The sugar consumption was low as compared with the national average, approximately 62 g/day. The protein consumption was approximately 2 g per kg body-weight per day. The median total energy intake was 8,024 KJ for girls and 8,569 KJ for boys lower than the recommended daily values and corresponded to a low levels of physical activity. This investigation showed a definite linear connection between the fat energy percentage and the serum cholesterol (alpha = 5.26 p less than 0.005) and that intake of saturated fatty acids, in particular can be related to the cholesterol level (alpha = 2.88 and p less than 0.005). A significantly greater fat energy intake was demonstrated in girls (p less than 0.05) in the group with high serum cholesterol levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Child↗

PubMed1989