Biomedical subjects

K K Mukherjee

Publications and source records attributed to K K Mukherjee.

At least 37 records · Page 2Linked to original sources

PubMed1995

Serosurvey of chikungunya antibody in Calcutta metropolis.

Since its first isolation in Calcutta, in 1963, there have been many reports about epidemis of chikungunya virus infection in different parts of India. Calcutta experienced a concurrent epidemic of dengue and chikungunya between 1963 and 1965. But after that there is no report about any chikungunya infection in Calcutta. During routine investigations it is found that chikungunya antibody is on the wane. The present survey for chikungunya antibody showed only 4.37% (n = 17) seropositivity out of 389 sera tested. The highest (12.5%) seropositivity was observed in the age group of 51-55 years and no chikungunya antibody was detected in young and young adults. The findings suggest that chikungunya virus is disappearing from the Calcutta population.

Adolescent↗

PubMed1995

An institutional outbreak of hepatitis E--reported first time from Calcutta city.

A sudden outbreak of hepatitis occurred in a micro-epidemic form, amongst the staff members of the School of Tropical Medicine, Calcutta, during May-June, 1995. A total of 21 persons developed jaundice, out of whom 11 members who attended the Virology Department and were tested for detection of different serological markers of hepatitis by ELISA. All the sera (N = 11) showed evidence of non-A, non-B infection by process of exclusion and 9 of the above sera showed evidence of anti-HEV when tested specifically. This is the first documented outbreak of viral hepatitis in respect of Calcutta.

Adult↗

PubMed1993

Dengue haemorrhagic fever (DHF) outbreak in Calcutta--1990.

An outbreak of Dengue Haemorrhagic Fever (DHF) occurred in Calcutta between September and December, 1990. Children and young adults were the major victims. Haemorrhagic manifestations and shocks were the main features in most of the hospitalised cases. Five mouse pathogenic agents were isolated from 105 acute cases and all were identified as DEN-3. HI and CF test with 55 paired sera revealed evidence of dengue infection in 33 (60 per cent) and flavivirus group reaction including dengue in 17 (30.9 per cent). It was for the first time, that DEN-3 was considered to be the etiologic agent for DHF in Calcutta.

Adolescent↗

PubMed1991

Recurrent outbreaks of Japanese encephalitis in Nagaland (1985-1989)--a seroepidemiological study.

Recurrent epidemics of encephalitis in Nagaland, a North-Eastern State of India, following its first appearance in 1985, were investigated both epidemiologically and virologically. Although, no viral agent could be isolated from any of the clinical samples and mosquitoes, detection of JE specific IgM antibodies in many of the CSF and acute blood samples, together with presence of HI and CF antibodies to JE antigen in a number of acute and convalescent sera established the etiologic role of JE virus in this region. A total number of 83 clinically diagnosed cases could only be investigated virologically between 1985-89, where evidence of JE could be established in 34 (40.9 per cent) and flavivirus (including JE in majority) in 17 (21.5 per cent) cases. A limited serological survey among the close contacts of the victims in 1985 revealed JE antibody in 26.6 per cent of them. Analysis of the epidemiological and serological findings of different years revealed that while the outbreaks of 1985, 1987 and 1988 were due to JE infection, the episodes of 1986 and 1989, on the other hand, had chiefly features of high and prolonged fever with limited number of CNS involvement of undetermined origin, where the possibility of malarial infection has been a suspect apart from JE etiology.

Adolescent↗

PubMed1989

Seroepidemiological study of Japanese encephalitis in Dimapur, Nagaland.

A seroepidemiological study of Japanese encephalitis (JE) in Dimapur, Nagaland was carried out following an outbreak of the disease between July, 1985 and February, 1986. Altogether 50 persons were affected with 30 (60 per cent) deaths. The attack and death rates per 1000 were more in Nagas viz. 0.55 and 0.34 than non-Nagas viz. 0.33 and 0.20 respectively. All ages and both sexes were affected. Of the nine mosquito species encountered Culex vishnui showed the highest density (44.5/MH). Culture of mosquito pool did not yield any viral agent. A total of 311 serum samples comprising 95 humans, 166 animals and 50 birds were tested for the presence of haemagglutination inhibition (HI) antibodies against Chikungunya and three flavirus antigens, viz. JE, WN and DEN-2. The overall flavivirus HI antibody in humans was positive in 26 (27.3 per cent) almost identical to JE antibody prevalence. The per cent positivity of HI antibodies to JE, WN and DEN-2 were 42.2 per cent, 22.2 per cent and 13.3 per cent in the affected and 14.2 per cent, 10 per cent and 6 per cent in the unaffected area. The activity of Alpha (Chikungunya) virus though very low was significantly higher (chi 2 = 5.57) in the affected area. The prevalence of JE antibody was 77.7 per cent in dogs, 52 per cent in cattle, 34 per cent in pigs and 21.1 per cent in goats. Of the five species of birds, flavivirus and JE antibodies were detected in 21.4 per cent pigeons and 22.2 per cent heron egrettes. Neutralisation test established the distinct role of JE virus over other related flavivirus antigens.

Adolescent↗

PubMed1987

Outbreak of febrile illness due to dengue virus type 3 in Calcutta during 1983.

An epidemic of dengue fever broke out in Calcutta between July and August 1983. Persons of all age groups were affected with a preponderance of young adults. Haemorrhagic manifestations and shock were not observed. Virus was isolated from 4 acute phase sera and identified as dengue type 3 (DEN-3), the first isolation of DEN-3 virus in Calcutta. Serotesting with 9 paired blood samples established dengue infection in 7 and a flavivirus group reaction in 2. Examination of 36 single sera revealed presumptive dengue infection in 15 and a flavivirus group reaction in 17, while the remaining 4 were negative to all flavivirus antigens.

Adolescent↗

PubMed1986

Density of Culex vishnui and appearance of JE antibody in sentinel chicks and wild birds in relation to Japanese encephalitis cases.

In the District of Burdwan, a rural area of West Bengal State, India, Japanese encephalitis (JE) virus is endemic. In one village a longitudinal survey was conducted in order to find out whether associations could be established between the density of the vector mosquito Culex vishnui in two types of resting places, the incidence of infections in sentinel chicks exposed at monthly intervals, the prevalence of antibodies in wild birds and the occurrence of clinical infections in the human population. The experiment lasted from August 1981 till August 1982. Meteorologically a summer season (March-June), a rainy season (July-October) and a winter season (November-February) are distinguished. In the sentinel chicks infections were observed in all three seasons; in wild birds antibodies were prevalent throughout the year; these observations suggest perennial transmission of the virus in its maintenance cycle. Human infections were observed periodically with, in August 1982, a pronounced peak; this may point to fluctuations in the level of circulation of the virus in its maintenance cycle and spillover to the human population at times of peak circulation. The peaks may be related to the influx of young non-immune birds and newborn mammals into the animal population in summer. Further studies, including virus isolation attempts from mosquitoes and nestling birds, are required to prove this hypothesis.

Animals↗

PubMed1984