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Biomedical subjects

K K Mustakallio

Publications and source records attributed to K K Mustakallio.

At least 37 records · Page 2Linked to original sources
PubMed1981

Polymorphic acetylator phenotype and systemic lupus erythematosus.

Out of 69 patients with spontaneous systemic lupus erythematosus (SLE), phenotyped for polymorphic acetylation with sulphadimidine, 52 (75%) were slow acetylators. In the subgroup of SLE patients with chronic biologically false positive seroreactions for syphilis the percentage of slow acetylators was even higher, 88%. In the majority of the slow acetylators the disease had started later and had followed a milder course than in rapid acetylators. Cutaneous reactions suspected to be drug-induced were seen in 19 (17 slow acetylators) during an observation period of 3--7 years. The reactions were mostly of exanthematous or urticarial type but also fixed type of eruption was seen. Provocation tests with the suspected drug were performed in 14 patients. In 5 cases it could be demonstrated that the eruption was caused by the drug. The predominance of slow acetylators among our patients with spontaneous SLE was the same as has been observed in drug-induced SLE. This suggests a similar genetic background.

Acetylation↗
PubMed1980

Irritation and staining by dithranol (anthralin) and related compounds: II. Structure-activity relationships among 10-meso-substituted acyl analogues.

Irritation and staining by dithranol and some 10-meso-substituted acyl analogues was studied with the chamber-testing technique in a series of 50 psoriasis patients. The test concentrations for dithranol, 10-acetyldithranol, 10-propionyldithranol and 10-butyryldithranol were 0.05 and 0.5%, for 10-valeryldithranol 5% and for 10-myristolydithranol 10%. As a rule, with increasing length of the carbon chain of the 10-acyl substituent (from 2C to 14C) the staining and irritative properties of the molecule decreased.

Anthracenes↗
PubMed1979

Irritation and staining by dithranol (anthralin) and related compounds: I. Estimation with chamber testing and contact thermography.

Irritation and staining by dithranol and some related compounds was studied with the chamber-testing technique in a series of 62 psoriasis patients. Suitable to routine testing of the individual tolerance to dithranol is the use of 0.05 and 0.5 per cent concentrations in petrolatum, exposure of the mid-back skin for 24 hours, and reading of the reactions (erythema, brown staining, edema) on the second day after the application. Contact themography was used when the brown stain hampered the extimation of erythema. Low concentrations of 10 acetyldithranol elicited weaker reactions than dithranol but at the 0.5 per cent level the acetylderivative tended to give stronger reactions than the parent compound. Ten per cent dithranol triacetate caused only occasionally slight erythematous reactions, whereas 10,10'-bis-(formylethyl) dithranol and dithranol anthraquinone elicited no reactions at all. The mechanisms of the staining and inflammatory reactions and possibilities of their reduction are discussed. The use of the chamber-testing technique is recommended to screening of new less irritating and staining hydroxyanthrones for clinical trial.

Administration, Topical↗
PubMed1977

Nodules on the legs. A clinical, histological and immunohistological study of 82 patients representing different types of nodular panniculitis.

Eighty-two cases of nodular panniculitis of the legs were examined clinically, histologically and immunohistologically. Clinically the cases could be divided into four groups: typical erythema nodosum (ENty) (35 cases), erythema nodosum migrans (ENmi) (11 cases), erythema induratum (EI) (11 cases) and the remaining 25 cases not consistent with the others as "non-definite panniculitis" (NDP). The main histological categories were septal panniculitis and lobular panniculitis, the former including erythema nodosum, both typical and migrans, the latter EI and NDP. Lobular panniculitis was divided into three subgroups in which the most prominent histological features were epithelioid cell granuloma, vasculitis and palissading granuloma, respectively. Immunoglobulins in the vessel walls were found in 5 of the 46 cases of erythema nodosum, in 19 of the 36 EI and NDP cases and, in the histological groups in 4 of the 43 cases of septal panniculitis and in 19 of the 35 cases of lobular panniculitis, respectively. Fibrin was found in the walls of the papillary capillaries and deep dermal vessels in the majority of cases of lobular panniculitis. In EI and NDP the follow-up time was 40 months, on average. Twenty-two patients were treated with antituberculous drugs, 15 became symptomless, as did 5 of the 12 patients who were not treated at all.

Adult↗
PubMed1977

A peripheral vascular syndrome overlapping with systemic lupus erythematosus. Recurrent venous thrombosis and hemorrhagic capillary proliferation with circulating anticoagulants and false-positive seroreactions for syphilis.

Three women and five men with chronic biological false-positive seroreactions for syphilis and circulating anticoagulants exhibited a vascular syndrome consisting of recurrent deep venous thrombosis of the extremities and necrotizing purpura with painful superfacial starlike ulcers around the ankles. The skin biopsies revealed a unique picture of massive proliferation of hemorrhagic dermal capillaries without a significant inflammatory reaction. Some virus infection may function as a trigger of this peripheral vascular syndrome, because 6 of the 8 patients had a preceding pneumonia with pleural vascular effusion. Considering that the three women had clinical and laboratory evidence of systemic lupus erythematosus (SLE) this syndrome may be related to SLE.

Adolescent↗