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Biomedical subjects

K K Nair

Publications and source records attributed to K K Nair.

At least 19 recordsLinked to original sources
PubMed1993

Coronary artery aneurysm.

A 55 year old man presented with a 2 year history of angina of effort complicated by two myocardial infarctions. Coronary angiography confirmed fusiform aneurysm of the right coronary artery and disease of the left anterior descending coronary artery. The patient underwent surgery with exclusion of the right coronary artery aneurysm and reversed saphenous vein graft, and graft to the left anterior descending coronary artery, with uneventful recovery. The clinical and radiological features are reviewed, and the surgical options considered.

Angina Pectoris↗
PubMed1993

Surgical removal of intracardiac foreign bodies.

When non-surgical methods for removing intracardiac foreign body have failed, surgical removal should be attempted. Two patients who had dislodged ventriculoatrial shunts for hydrocephalus underwent open removal of catheters, one from the pulmonary artery while the other from the right atrium. Both were successfully retrieved without cardiopulmonary bypass. We describe the clinical and radiological features, with a review of the indications and techniques available.

Adult↗
PubMed1993

Giant left ventricular aneurysm.

A 65 year old lady with known inferior left ventricular aneurysm presented with acute dysphagia and hoarseness. A barium swallow examination confirmed extrinsic compression of the oesophagus. Successful aneurysmectomy resulted in complete relief of the dysphagia and hoarseness. The clinical and radiological features are reviewed.

Aged↗
PubMed1991

Unusual migration of a Kirschner wire.

Orthopaedic procedures involve utilization of internal fixation devices. Screws, wires and plates are removed due to loosening or infection. Migration of these devices is also well established. We present an unusual case of migration of a Kirschner wire from the right shoulder to the spleen within a period of 12 h. Review of the literature does not reveal any previous occurrence of this nature.

Aged↗
PubMed1987

Changes in ploidy level of epidermal cells during last larval instar of the tobacco hornworm, Manduca sexta.

The relative DNA content of Manduca sexta abdominal epidermal nuclei during the final larval instar was measured by cytophotometry of whole-mount preparations of the epidermis. In the middle intrasegmental region, epidermal cells showed a ploidy level of 4C to 32C on the day of ecdysis. During the subsequent period of feeding, the proportion of higher ploidy cells, such as 16C and 32C, increased. This situation remained until the day of apolysis preceding pupal cuticle formation when mitoses reduced the cells to 2C, 4C, 8C and 16C, except for the pupal pock-mark cells, which increased to 32C or 64C. Metaphase cells showed various ploidy levels, correlated with the size of their mitotic figures. By contrast, in the anterior and posterior margin of a segment where no mitoses occurred, the cells continued to increase in ploidy throughout the instar.

Animals↗
PubMed1986

Effects of increased lifespan on chromatin condensation in the adult male housefly.

Analysis of the chromatin condensation pattern in optic lobe nuclei from the adult male housefly has shown significant differences in males from a long lived, low activity (LA) group as compared to a short lived, high activity (HA) group. The rate of chromatin condensation in the LA group was very much less than that observed in the HA group, leaving the nuclei from the former group in a permanently lowered condensation state. Moreover, a detailed comparison of the amount and spatial distribution of a single high density chromatin component (HDC) suggests that the low activity conditions not only lowers the rate of chromatin condensation but also alters the normal program controlling this process. Linear discriminant analysis showed that a consistently higher percentage of nuclei from the LA group, as compared to the HA group, could be classified with a 1-day-old model derived from the HA group. These results are discussed with respect to environmental influences on lifespan and are compared to the response of lipofuscin accumulation in low activity male houseflies.

Animals↗
PubMed1985

Age-related chromatin condensation in flight muscle nuclei of the adult male housefly, Musca domestica.

Computer analysis of indirect flight muscle nuclei from the adult male housefly, M. domestica, has shown significant change with age in the chromatin condensation pattern. The pattern was analyzed by examining low, medium, and high density chromatin components (LDC, MDC, HDC). No significant change occurred in HDC with age, and the amount and distribution of LDC and MDC remain relatively stable between Day 1 and Day 4 post-eclosion. However, the analysis showed a significant increase in the amount of MDC with a corresponding decrease in the amount of LDC between Day 4 and Day 14. This exchange was accompanied by a significant redistribution of both components. These results are discussed with reference to the biochemical and ultrastructural profile of the flight muscle with age, and to age-related changes in the condensation pattern of specific brain and Malpighian tubule nuclei described earlier.

Aging↗
PubMed1982

Transantral ligation of the internal maxillary artery.

Transantral internal maxillary ligation for epistaxis is becoming more and more popular. The intention of this paper is to bring home three points: 1. only the arterial trunk need be ligated to obtain the anticipated results, 2. by following certain guidelines the operating time can be cut down by at least 45 minutes, and 3. if the procedure is carried out in time, it can be cost-effective. As time goes on, more and more patients will be added to this analysis and eventually reported.

Epistaxis↗
PubMed1981

Carotid vascular pain--a simple treatment.

Carotid vascular pain has been misdiagnosed in the past as various other conditions. Various etiologies have been assigned to it without clinical or experimental evidence. Haphazard treatment using ganglion-blockers, nicotinic acid, allergy hyposensitization and steroids have been instituted based on imaginary causes of the problem. This paper intends to show that there is no known cause for carotid pain. A simple, effective, safe and inexpensive form of treatment is presented; namely, explaining the problem to the patient, allaying their apprehension and using aspirin in a more scientific fashion. A three-year follow-up is presented.

Adolescent↗
PubMed1980

Image analysis of hepatocyte nuclei from chlordane-treated rats.

The treatment of rats with hepatic dysfunction with chlordane at below the "no-effect" dose produces an increase in the number of hepatocyte nuclei with doubled DNA content. More important, though, it can be shown that even cells with unaltered DNA contents undergo statistically significant changes in their chromatin distribution pattern. Thus, image analysis techniques are capable here of detecting and substantiating toxic effects not apparent by visual inspection.

Animals↗
PubMed1979

Clinical trial of diaminodiphenylsulfone (DDS) in nasal and nasopharyngeal rhinosporidiosis.

Rhinosporidiosis is a fairly common problem for the Otolaryngologist in many parts of the world, because of its prompt recurrence after surgical excision. Though not a fatal disease, it inflicts various kinds of social and economic strain on the patients and their families. No medical treatment has been found to be effective in controlling rhinosporidiosis. Such drugs as griseofulvin and amphotericin have been tried without much benefit. In this clinical trial with dapsone on 32 patients (71.4%) did not have recurrence in a three year period and none of them needed surgery in that period. Thirty-two patients were used as controls, and 93% of them needed surgery for recurrent rhinosporidiosis in the same three year period. Dapsone (diaminodiphenylsulfone) is a relatively safe drug to use, and no major side effects were noticed in this trial.

Dapsone↗