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Biomedical subjects

K K Sachdev

Publications and source records attributed to K K Sachdev.

12 recordsLinked to original sources
PubMed1982

Trigeminal nerve stimulation: short latency somatosensory evoked potentials.

We have devised a technique to measure trigeminal somatosensory evoked potentials, stimulating the mentalis nerve at the mandibular foramen and recording the evoked early potential on the scalp at 3.2 msec. The early potential was easily recognized in all normal subjects and on the asymptomatic side of patients with facial pain. The latency of the early potential in normals was 1 to 2 msec less than half the latency of the mechanically induced jaw jerk. The early potential appeared simultaneously on both sides after stimulation of either the right or left mentalis nerve and may have its origin in deep brainstem structures, the Gasserian ganglion, or the trigeminal nerve. The technique is useful in documenting the functional integrity of peripheral and central afferent pathways of the trigeminal nerve.

Adult↗
PubMed1980

Juvenile muscular atrophy localized to arms.

Twenty-four patients from India, had juvenile muscular atrophy localized to the upper extremities. The condition characteristically affects young men and is not familial. Atrophy is limited to the hand and forearm muscles, with slow progression for two to three years after which it seems to be stationary. The condition is associated with "tremor-like" movements out of proportion to the weakness. Examination of muscle biopsy specimens shows group 2 fiber atrophy. This syndrome, for which no cause has been described, is benign and self-limiting, unlike most motor neuron diseases, and is distal in upper extremities, unlike Kugelberg-Welander disease. Asymmetrical muscle wasting and preceding febrile illness in some patients suggests an atypical poliomyelitis-like viral disease.

Adolescent↗
PubMed1977

Juvenile parkinsonism treated with levodopa.

We describe three patients with early onset of parkinsonism. Two of these were sisters and showed a reduction in homovanillic acid (HVA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) levels in the CSF. In the third patient, parkinsonism developed, which was probably related to chickenpox encephalitis. All three patients responed favorably to levodopa therapy.

Age Factors↗