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K Kühndel

Publications and source records attributed to K Kühndel.

36 records · Page 2Linked to original sources
PubMed1980

[Low temperature biopsy of biological tissues (author's transl)].

A method and an equipment are described to perform a low temperature biopsy. The advantages of this method are the immediate conservation and the excellent topical conjugation of tissue. Using the effect of adherence it is also possible to get a biopsy from tissues of a high rupture strength. We used this cryobiopsy method for histological diagnosis of colposcopically suspicious areas of the ectocervix uteri, where the representation of relations between epithelium and stroma is of practical importance.

Biopsy↗
PubMed1978

[Relationships between the HPL determination in maternal serum and the condition of the associated placental villous trophoblast].

Relationships between the determination of human placental lactogen in materna serum and the condition of associated placental villous trophoblasts.--Taking as a starting point both qualitative and quantitative differences in the composition of placental villous trophoblasts subsequent to risk pregnancies, the proportions of different qualities of syncytium and average numbers of Langhans' cells per field of view in 24 placentas of neonates of the 37th to 41st weeks of pregnancy are compared with the corresponding maternal serum HPL (human placental lactogen) values. The significantly lower proportion of mature syncytium determined in the case of a low HPL value as well as the result of linear regression analysis are indicative of a dependence of maternal serum values for HPL upon the proportion of mature syncytium. This particular result is also interpreted by the authors as confirming the view that "mature" syncytium can be considered to be "functional" syncytium. Like other investigators, the present authors should also point out the importance of the total mass of placenta which can compensate for lower proportions of functional syncytium in individual resorption villi. Whereas there are clearly evident relationships between the maternal estriol values and the condition of placental villous trophoblasts, such relationships could not be observed in our material for oxytocinase and HSAP.

Alkaline Phosphatase↗
PubMed1977

[Impulse cytophotometric studies in cytologically suspicious cervical smears].

187 women with cytologically suspicious cervical smears (Papanicolaou III to V) were investigated by 387 pulse cytophotometric (ICP) measurements. Within the Papanicolaou III group a significantly higher 4c-peak was seen in cases with only one ICP-investigation if we had histologically pathological findings (dysplasia, carcinoma) as contrastes with clinically and cytologically regressive cases. In repeated ICP-investigations we found in group Papanicolaou III (histol.: dysplasia, carcinoma) as well as in group Papanicolaou IV and V a significantly higher mean 4c-height than in only once investigated cases. Within a ICP-series the maximal 4c-height is most representative. The security of diagnosis is raising with repeating ICP-investigations. Here it is a valuable diagnostic aid especially in suspicious cases. All abnormal ICP-findings must be controlled for a long time, even with normal cytological smears. At last, the circumstances causing false negative ICP-results are discussed.

Cell Nucleus↗
PubMed1976

[Pulse cytophotometric and cytologic repeated examinations of cervical secretions as compared with histologic findings (author's transl)].

1625 cervical smears from 397 women were investigated in special cytological consultations. On the same material 693 impulse cytophotometric (ICP) measurements were made, stained with ethidium bromide after pepsination. In 207 patients the diagnosis was certain by histology. The mean height of the 4c-peak (in 0/00 of the 2c-peak) raises with the Papanicolaou grading from 38,2 in Pap. I up to 128,8 in Pap. V. In histological confirmed cases in dysplasia the mean 4c-height was 79,5 and in carcinoma 102.2. If only one ICP investigation was turned to account there are some disagreements between the ICP value and the diagnosis finally resulting from the clinical and cytological course. The differences are considerably diminished by repeated ICP investigations. Therefore ICP measurements are a valuable aid in interpreting cytodiagnostic problems. They often facilitate the choice of further diagnostic and therapeutic procedures.

Cervix Uteri↗
PubMed1976

[Results of cytological and histological studies on the uterine cervix after long-term intake of hormonal contraceptive agents].

Cytologic examinations with 880 women having constantly used oral contraceptives from one to eight years show no agglomeration of epithelial atypias if the primary status was clearly in the negative. Among 669 histologically sure atypias of cervix uteri the part of women using oral contraceptives for at least one year is significantly lower in carcinoma in situ as well as in early invasive carcinoma. The differences in dysplasia are not significant. The results are also discussed with regard to the efficiency of permanent control examinations before and during the use of oral contraceptions. The demand of a further intensification of cytodiagnostic is derived from these examinations.

Adolescent↗
PubMed1975

[Biological validity, cytodiagnosis, and therapy of cervix dysplasia].

Certain forms of dysplasia are biologically equal to carcinoma in situ and should be treated alike. The persistance of the state during the permanent cytologic control is to be regarded as criterion for the treatment of middle and even the slight dysplasia. Slides of cells indicating a dysplasia are therefore placed in a cytologic risk-group III D. If the restoration of the cytologic state cannot be observed within 12 months, the conisation as carcinoma prophylaxis of slight and middle forms of dysplasia should be performed.

Carcinoma in Situ↗