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Biomedical subjects

K KAY

Publications and source records attributed to K KAY.

At least 19 recordsLinked to original sources
PubMed1963

Tuberculin hypersensitivity: studies with radioactive antigen and mononuclear cells.

The type and fate of mononuclear cells of guinea pigs hypersensitive to tuberculin were studied by means of purified protein derivative labeled with I(125) and mononuclear cells labeled with tritiated thymidine. Purified protein derivative labeled with I(125) was taken up in vitro by lymphocytes and neutrophils from animals that were either sensitive or nonsensitive to tuberculin, but it was bound more frequently by the cells of sensitive animals. Passive transfer of tuberculin hypersensitivity by means of lymphocytes labeled with tritiated thymidine indicated that significant numbers of radioactive cells migrated to the site where the skin was tested with purified protein derivative only when the test was made immediately after transfusion. Although skin reactions from tests made with purified protein derivative 24 hours after transfusion were comparable to those from tests made immediately, the number of labeled cells at the sites of the later tests was not consistently larger than it was in controls (Histoplasmin reactions). Thus transfused tuberculin-sensitive cells are neither always attracted to the sites of the test with purified protein derivative nor are they required in large numbers at the site for a positive reaction to develop.

Animals↗
PubMed1957

Control of health hazards likely to arise from the use of organo-phosphorus insecticides in vector control.

The widespread use of DDT and the chlorinated hydrocarbon group of insecticides for the control of mosquitos and flies has led to the emergence of resistant strains of flies. Where the DDT group of insecticides is ineffective for the control of resistant insects, it appears that the use of the organo-phosphorus group of insecticides may be an alternative. However, it seems probable that their introduction and application under the same conditions in which DDT has been safely used might carry serious risks to the health of the men who apply them. In this paper, the authors indicate what these dangers are, how they manifest themselves, and how they might be controlled. Four methods of blood-cholinesterase determinations, carried out in the laboratory and in the field, are described in an annex.

Cholinesterases↗