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Biomedical subjects

K Kaemingk

Publications and source records attributed to K Kaemingk.

5 recordsLinked to original sources
PubMed2000

Cognitive consequences and central nervous system injury following treatment for childhood leukemia.

OBJECTIVES: To determine the relationship between membrane damage and intellectual and academic abilities in children with acute lymphoblastic leukemia (ALL) and pilot test a math intervention for children with ALL who were affected. DATA SOURCES: Research studies and review articles. CONCLUSIONS: Despite the prophylactic central nervous system (CNS) treatment for long-term disease-free survival, many children with ALL subsequently experience declines in intellectual and academic skills. IMPLICATIONS FOR NURSING PRACTICE: Improving academic abilities in children who have received CNS treatment is of high priority and may have longlasting implications on quality of life.

Analysis of Variance↗
PubMed1989

Behavioral and autonomic responses to peer separation in pigtail macaque monkey infants.

Brief maternal separations of young nonhuman primates have been used extensively to study the behavior and physiology of attachment, loss, and bereavement. The physiological responses to the loss of alternative attachment figures, such as peers, is less well documented in nonhuman primates. This study examined both autonomic and behavioral responses of peer-reared pigtail macaque infants to separation. Eight infants were removed from their mothers at birth and reared in four peer pairs. At 6 months of age, each monkey was implanted with a multichannel biotelemetry device which transmitted heartrate, body temperature, EEG, EMG, and EOG. Blood was collected twice weekly for immunological assessment. Behavioral and physiological data, including sleep, were collected for 1 week of baseline, 2 weeks of separation, and 1 week of reunion. Behavioral and physiological results indicated agitation but not depression following separation from their peer attachment figures. We found reduced mitogenic responses to pokeweed consequent to peer separation, suggestive of altered B-cell function. REM variables were the only sleep measures affected by the separation, and were suggestive of agitation but not depression.

Animals↗
PubMed1989

Maternal separation in bonnet monkey infants: altered attachment and social support.

Maternal separation in young pigtail (M. nemestrina) monkeys results in an agitation-depression reaction that is a useful animal model of the behavioral and physiological consequences and separation and loss experiences in humans. In this study, 5 social-group-living bonnet (M. radiata) monkey infants were separated from their mothers for 4 days, and behavioral, physiological, and sleep-pattern changes were monitored. Behavioral and physiological changes were consistent with an agitation reaction. There was evidence of depression in both behavioral and physiological measures; these changes were not as pronounced as in pigtail infants, however. All infants were adopted by another adult female during separation. Our findings suggest that, in bonnet monkey infants, adoption by a female within the social group ameliorates the response to loss.

Animals↗
PubMed1987

Social environment and nocturnal sleep: studies in peer-reared monkeys.

Nocturnal sleep was recorded for a total of 40 nights by means of totally implantable, multichannel biotelemetry from 11 peer-reared pigtail (Macaca nemestrina) monkey infants (aged 221 +/- 28 days). Fourteen sleep variables were compared to values previously obtained from similar-aged, mother-reared infants living in social groups. Sleep in peer-reared monkeys was more fragmented, contained less drowsy, more stage 2, less REM, fewer REM periods, and longer interREM intervals than sleep in mother-reared infants. It would appear that these effects are not due to a relatively impoverished environment that may accompany peer rearing, as has been reported to be true for rodents, but rather to the disruptive influence of sleeping with a peer in the absence of the organization and control effected by a monkey mother and a social group.

Animals↗