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Biomedical subjects

K Kamel

Publications and source records attributed to K Kamel.

At least 19 recordsLinked to original sources

Hemoglobin D-beta (0) thalassemia. A case report and family study.

Findings are presented on a Pakistani family in Doha, Qatar with hemoglobin D-Los Angeles (alpha 2 beta 3 121 (glutamine----glycine) and thalassemia trait. The propositus, a child, has hemoglobin D-beta(0) thalassemia, and suffers from moderately severe hemolytic anemia. The father has beta-thalassemia trait, and the mother is heterozygous for hemoglobin D-Los Angeles. This, the eighth confirmed case in the medical literature, is reported to emphasize its clinical manifestations and genetic basis.

Hemoglobins, Abnormal↗

Hb Doha or alpha 2 beta 2[X-N-Met-1(NA1)Val----Glu]; a new beta-chain abnormal hemoglobin observed in a Qatari female.

Structural analysis of a fast-moving hemoglobin variant, present in three members of a Qatari family, identified a Val----Glu substitution at position 1 (NA1) of the beta-chain. The introduction of this glutamic acid residue prevents the removal of the initiator methionine, thus extending the N-terminus by one residue to Met-Glu-His-Leu-Thr-. The methionine residue is blocked by an as yet not completely identified molecule. The presence of the variant in a heterozygote does not have clinical consequences.

Adult↗

Hematological observations on Arabian SS patients with a homozygosity or heterozygosity for a beta S chromosome with haplotype #31.

Hematological and hemoglobin composition data are presented for seven Arabian SS patients with mild disease and with high Hb F levels varying between 21 and 34%. Four patients were homozygous for a beta S chromosome with a specific haplotype (#31). The data for these four patients were similar to those for three other SS patients (and for five patients reported earlier, Ref. 2) who were heterozygous for the same beta S chromosome (#31) and for a beta S chromosome with another haplotype (mainly #19). These data offer additional evidence indicating that the increased gamma chain production is specific for the beta S chromosome with haplotype #31. The similarities in hematological data and Hb F levels between these two groups of SS patients and the normal Hb F value in Hb S heterozygotes with beta S chromosome (#31) support the suggestion that the increased Hb F production mainly occurs in response to the anemia of the sickle cell disease.

Adult↗

Blood groups and types, hemoglobin variants, and G-6-PD deficiency among Abu Dhabians in the United Arab Emirates.

Some erythrocyte genetic factors were studied in the indigenous population of Abu Dhabi, the capital of the United Arab Emirates, on the southeastern coast of the Arabian peninsula. Determinations carried out included blood groups and types ABO, MNS, Rh0, KkJsa, FyaFyb, P1, Lea, Vela, hemoglobin variants, and screening for G-6-PD deficiency. Prevalence of most blood groups and types harmonized with that among neighboring Arabs and some Arabs elsewhere. The MS and NS gene complexes were noticeably high. African admixture was expressed by the presence of Jsa and HbS and large numbers of Fy. G-6-PD deficiency was rather high.

Blood Group Antigens↗

Blood levels of selected nutritional status indicators in young men from a rapidly modernizing society in Abu Dhabi, United Arab Emirates.

Some blood levels of selected indicators of nutritional status were assessed in young adult males among the rapidly modernizing bedouin society of Abu Dhabi. Blood specimens from 30 indigenous army recruits were tested for the following: packed cell volume, total serum proteins, albumin, globulins, serum transferrin, serum calcium (total and ionized), serum iron, and total folates in serum and in red blood cells. A control group consisted of 10 male expatriate laboratory personnel of similar age. Except for iron and folates, all parameters were within normal range. Although the average serum iron was normal, 13.3% of the army recruits were serum iron deficient. The mean serum folate in both groups fell within the indeterminate range with two deficient recruits. The mean red blood cell folate was in the low normal value in the local people with one-third of them in the borderline range, and two deficiencies with no pathological effects. The control group was well within the acceptable normal range of red blood cell folate and the difference between the means of both samples was significant. Inappropriate amounts of vegetables in the diet and prolonged cooking may be the cause of such folate inadequacy.

Adolescent↗

Heterogeneity of sickle cell anaemia in Arabs: review of cases with various amounts of fetal haemoglobin.

A study is presented on eleven patients with homozygous sickle cell anaemia. They are non-Sheeah Arabs from the United Arab Emirates on the south-eastern coast of the Arabian Peninsula. The proportions of fetal haemoglobin in these patients are variable, and there is a marked variation in the severity of their disease condition; these facts are not related. African sickle cell gene admixture is a likely affecting factor.

Anemia, Sickle Cell↗

Purification of Neisseria gonorrhoeae surface L-antigen.

A purified preparation of the L-antigen of Neisseria gonorrhoeae with a 40-fold increase of antigenic activity over the crude extract was prepared. The antigen was extracted from the cell envelope by mild treatment with sodium dodecyl sulfate and purified by Sepharose 4B, diethylaminoethyl-cellulose, and diethyl-(2-hydroxypropyl)aminoethyl (QAE)-Sephadex column chromatography. The purified antigen was heat labile and trypsin sensitive. The smallest antigenically active subunit appeared to have a molecular weight of 38,500, as shown by polyacrylamide gel electrophoresis of the product incubated with sodium dodecyl sulfate.

Antigens, Bacterial↗

Anthropological studies among Libyans. Erythrocyte genetic factors, serum haptoglobin phenotypes and anthropometry.

Anthropological studies were done on 1276 Libyans from the Mediterranean cities of Tripoli and Benghazi, and from Sabha southward in The Sahara. The incidences of hemoglobin (Hb)-S and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency were low in the coastal areas and significantly high in Sabha. Hb-C occurred sporadically in Tripoli and Sabha, and was absent from Benghazi in the east. One case of Hb-J Benghazi was noted. There were no sigificant differences in the ABO blood group and Rh0 (D) type distributions in the three localities. G-6-PD gene GdAfrequency was significantly high in Sabha. The lowest value of 6-phosphogluconate dehydrogenase (6-PGD) gene PGDA frequency and highest value of the gene PGDC were in Sabha. Adenylate kinase (AK) gene AK2 was only detectable in Tripoli. Acid phosphatase (AP) gene Pa frequency in Sabha was more than twice that in Tripoli and Benghazi, while pc was distinctly lower in Sabha than in the northern cities. Haptoglobin gene Hp1 frequency was almost identical in all areas. Anthropometric measurements revealed overall homogeneity of the three samples, closer similarity in the coastal region to adjacent North African populations, and Negroid influence in the Sahara Libyans. Anthropometry substantiated findings from blood markers.

ABO Blood-Group System↗