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Biomedical subjects

K Kanesada

Publications and source records attributed to K Kanesada.

6 recordsLinked to original sources

Vestibular neuronitis in children.

Seventeen cases of vestibular neuronitis in children, including 11 cases from the questionnaires of an epidemiological survey in Japan and 6 patients in our clinic, were examined. Sex and age distribution was 11 males and 6 females, ranging in age from 3 to 15 years. Bilateral and recurrent cases were not encountered. Fifty-three percent of children had had a preceding episode of an upper respiratory tract infection and this ratio was higher than that in adults. The etiology of vestibular neuronitis is probably many-faceted, but it is thought that upper respiratory tract infections play an important role especially in children. Vertiginous symptoms had almost subsided among children at the last visit. However, among adults, 24% of patients felt persisting unsteadiness. The disappearance of positional and positioning nystagmus was observed in 71% of children at the last visit. Caloric CP failed to recover in only 14% of all cases who were re-examined. As shown in this study, the prognosis in children is better than in adults for nystagmus and caloric response. The results of this study thus indicate that not only central compensation but also recovery of the peripheral vestibular function is more effective for bringing recovery from the vestibular disorder in children than in adults.

Adolescent

Analysis of the fast phase of per-rotatory nystagmus.

We studied the relationship between the fast phase velocity and amplitude of per-rotatory nystagmus resulting from constant angular acceleration and deceleration stimulation. The relationship was nonlinear and was best fit to the exponential equation. We established the uppermost point of the data distribution along the resolution curve. In normal subjects the angular rotatory stimulation using a computer-controlled rotatory chair (ROKOS-6) with 5 degrees/s2 rotation was the best among three kinds of angular rotatory stimulation (1.2 and 5 degrees/s2). Compared to peripheral vestibular disorder the uppermost point of nystagmus had a tendency to be larger in amplitude in some cases with central vestibular disorder. In many cases with sudden deafness the same tendency was seen.

Acceleration

[Localized amyloidosis of larynx. A case report and immunohistochemical study].

A case of the localized laryngeal amyloidosis was reported. The patient was a 51-year-old female who complained of hoarseness for about a year. Pathological study on the biopsy specimen taken from both the subglottic area under laryngeal microsurgery showed the deposit of amyloid. Laryngeal microsurgery showed the deposit of amyloid at bilateral subglottic area. Electron microscopic study disclosed a typical amyloid fibrillar structure. Amyloid protein, in this case, was confirmed as protein A lambda appeared through the potassium permanganate treatment and immunoperoxidase technique (ABC method).

Amyloid

Counter-rolling after regional destruction of the saccule by laser spot irradiation in the guinea pig.

Destruction of the anterior one-third of the right saccule in the guinea pig resulted in a marked eye deviation simultaneously towards the ear and downward on the operated side and a marked upward eye deviation on the non-operated side in the standard head position. During head inclination towards the operated side, both eyes showed a disturbed ocular counter-rolling (OCR). The disturbance of OCR was more severe in the eye on the operated side than in the eye on the non-operated side. Brief interpretation about eye position in the standard head position in the regional destructive group showed that the eye ball on the operated side showed a marked deviation simultaneously upward and towards the ear, while the eye ball on the non-operated side showed an upward deviation on the 1st and 3rd days after the operation. OCR after regional destruction was seen as follows: During head inclination towards the operated side, both eyes showed disturbed OCR. The disturbance of OCR was more severe in the eye on the operated side. Most animals in our experiment showed this disturbed OCR which was compensated and normalized by the third postoperative week; relatively shorter (faster) than the total destruction. These results suggest that when the head is inclined around its longer axis, the saccule on the side of head inclination plays a principal role in the otolith-ocular reflex.

Acceleration

Bilateral peritonsillar abscesses.

A case of bilateral peritonsillar abscesses is reported. The patient was a 31-year-old male presenting with a severe sore throat, dysphagia, trismus and bilateral swelling of the soft palate causing no displacement of the uvula. Incision and drainage (I and D) and an interval tonsillectomy cured this condition. On review of the literature, it was noted that bilateral peritonsillar abscesses are not uncommon. Peritonsillar abscesses possibly occur bilaterally, but as the developmental stages of the abscesses are not simultaneous, immediate tonsillectomy or intensive antibiotic treatment following I and D controls the formation of the opposite side abscess in most cases.

Adult