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K Kanno

Publications and source records attributed to K Kanno.

106 records · Page 6Linked to original sources
PubMed1977

Elastin sub-fraction as binding site for lipids.

Elastin preparations were isolated from human thoracic aorta, from atherosclerotic and from grossly normal regions. A relatively mild procedure was used to avoid hot alkaline extraction and autoclaving. The elastase digest of the aortic elastin was chromatographed on a Sephadex G-100 column and separated into two fractions: A (larger molecular weight) and B (smaller molecular weight). The ratio of fraction A to total aortic elastin increased with age and the development of the atherosclerosis. Amino acid and sugar analyses showed that fraction A consistently contained more polar amino acids, hexose, hexosamine and L-fucose, and less sialic acid, in comparison with fraction B. Part of the elastin preparation was incubated with human low-density lipoprotein; a considerable amount of lipid, especially cholesterol, was transferred from the lipoprotein to the elastin. Estimation of protein and cholesterol in fractions A and B of the elastase hydrolyzate of incubated elastin showed that most of the cholesterol taken up by elastin had been in fraction A. The increased proportion of fraction A in aortic elastin derived from plaque areas appeared responsible for the marked lipid-binding capacity of plaque elastin.

Age Factors↗
PubMed1977

[Hemodynamic and respiratory function following acute spinal cord injury (author's transl)].

Twenty two cases of the cervical and thoracic cord injury were studied to determine hemodynamic and respiratory function within 7 days from the injury. Most patients showed a tendency of bradycardia and hypotension on admission which were more remarkable in the group of lower cervical cord or the upper thoracic cord lesion than the upper cervical cord group. Such a hypotension and bradycardia tended to recover within 7 days. In cervical cord injury, cardiac output remained unchanged, which indicated that initial hypotension was due to decreased total peripheral resistance. Respiratory rate was slightly increased in most patients, but did'nt show any significant difference among the level of the lesion. PaO2 and PaCO2 were within normal range on admission, however PaO2 decreased gradually in 7 days only in cervical cord injury. Increased pulmonary arterial pressure was confirmed during the above hypoxemic period. It suggests that disturbance of neurological control of pulmonary circulation might play a significant role in the respiratory insufficiency of cervical cord injury.

Adolescent↗
PubMed1975

Low serum alpha-1-antitrypsin level as a contributory factor of combined emphysema in silicosis.

In order to evaluate low serum alpha-1-antitrypsin level as a contributory factor of combined emphysema in silicotic patients, serum alpha-1-antitrypsin analysis was carried out in 80 patients with silicosis. Low serum alpha-1-antitrypsin level was found in 5 patients. Large opacities were observed roentgenologically in only 1 out of these 5 cases in contrast to 31 of the other 75 cases. Also the suggestive findings for the emphysema were showed in 4 of these 5 cases while such findings were found on their chest X-ray films in only 43 of the other 75 cases. FEV 1.0% below 50 were calculated in 3 of the 5 cases, on the contrary in 22 of the 75 cases. RV above 50% predicted value was showed by all the 5 low antitrypsin patients, in contrast to only 25 of other 74 cases. The silicotic patients with low serum alpha-1-antitrypsin concentration are most likely to have an association with a high incidence of complicated emphysema.

Adult↗
PubMedDate not supplied

Arterial dynamic appearance of common bile duct carcinoma by helical CT on angiography (angio-HCT): four operated cases.

We present four cases of common bile duct carcinoma in which both angiographic helical CT (angio-HCT) and pancreatoduodenectomy were done in the 3 years since 1995. Angio-HCT was performed with direct infusion of the contrast medium through the gastroduodenal artery inserted on angiography. Angio-HCT displayed the tumors as lower density areas in contrast to the strong enhancement of the circumferential nontumorous areas, including the pancreas and duodenum.

Adenocarcinoma↗