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K Kawanabe

Publications and source records attributed to K Kawanabe.

49 records · Page 3Linked to original sources

Determination of oxidizable inorganic anions by high-performance liquid chromatography with fluorescence detection and application to the determination of salivary nitrite and thiocyanate and serum thiocyanate.

A sensitive method for the simultaneous determination of oxidizable inorganic anions (sulphide, thiocyanate, thiosulphate and nitrite) was developed by use of high-performance liquid chromatography and fluorimetric detection based on the formation of fluorescent cerium(III) by a redox reaction with cerium(IV). The detection limits are 0.1 nmol for both thiocyanate and nitrite, 0.3 nmol for thiosulphate and 0.8 nmol for sulphide per 10-microliters injection volume. This system can be utilized for the determination of salivary thiocyanate and nitrite and serum thiocyanate.

Anions↗

Application of thin-layer stick chromatographic identification test methods to drugs contained in preparations in the pharmacopoeia of Japan.

A simple, precise technique was developed for identifying the drugs in preparations containing crude drugs listed in the Pharmacopoeia of Japan using thin-layer stick chromatography (TLSC), which is an advanced version of thin layer chromatography in a cylindrical form. The target component in preparations and crude drugs could be detected easily by dipping the developed chromatographic stick in specific colour reagents or by exposure to ultraviolet rays. This technique was applied to the identification of drugs such as salicylic acid, phenol, acrinol and alkaloids and also vitamins contained in the 36 kinds of preparation.

Absorption↗

A modified dose monitoring system in remote afterloading therapy of carcinoma of the uterine cervix using semi-conductor dosimeter.

A dose monitoring system in high dose rate intracavitary remote afterloading therapy of carcinoma of the uterine cervix using semi-conductor dosimeter was developed in July 1979 at our department. During early experience with the above system, extremely high values of mgh as well as high doses to rectum and bladder were encountered in the cases with poor local anatomy or unsuitable application. Solving this problem, such limitations as to the mgh as well as point-A dose were added to the computerized rapid processing system for the pretreatment dose calculation and correction of the treatment parameters to adjust the point-A dose to within +/- 5% of the planned dose. In the majority of the cases treated with Ralstron, this modified dose monitoring system brought considerable success in the optimization of point-A, mgh, rectal and bladder doses, in a simple manner.

Brachytherapy↗

A dose monitoring system in high dose rate intracavitary remote afterloading therapy of carcinoma of the uterine cervix using semi-conductor dosimeter.

Our intention was to develop a high accuracy procedure in high dose rate intracavitary remote afterloading therapy of carcinoma of the uterine cervix similar to the accurate dosimetry used in external irradiation. Semi-conductor in-vivo-dosimetry was carried out in order to determine the extent of errors in the calculated dose at reference points and in the definition of point A. The use of a rapid processing computerized system before the treatment was developed in order to decrease the difference between the dose delivered at point A dose and the planned dose. Errors in calculation of within +/- 10% seemed to be unavoidable in the hgh dose rate intracavitary afterloading therapy of carcinoma of the uterine cervix. Two definitions should be used in patients to compute the point A dose according to the ovoid position. Using the rapid processing system, wo could deliver a point A dose within +/- 5% level of the planned dose. The remotely controlled afterloader was safely operated by means of in-vivo-dosimetry which was backed up in routine clinical practice by a pretreatment calculated dose.

Brachytherapy↗