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Biomedical subjects

K Kayashima

Publications and source records attributed to K Kayashima.

At least 37 records · Page 2Linked to original sources
PubMed1996

[A reliable method for internal jugular vein catheterization for neonates and infants using a small-caliber Doppler probe].

Eighteen neonates and infants scheduled for cardiac surgery, ranging from 1 to 42 months in ages and from 1.9 to 14.6 kg in weight, were placed in supine position under general anesthesia. The neck was moderately extended with the head turned to the left. The pathways of the right carotid artery and the internal jugular vein (IJV) were located with a Doppler probe (2.0 mm in diameter, HAYASHI Electric, TOKYO) using 10 MHz ultrasound wave. The pathways of the vessels were drawn on the skin surface and the IJV was cannulated with a 24-gauge catheter over needle (Neophron, Ohmeda, USA) along the drawn pathway. A 0.015-inch guidewire was passed through the 24-guage catheter, and a central venous catheter was placed in the IJV employing to the Seldinger method. In 16 out of 18 patients the pathways of the IJV was clearly differentiated from that of the carotid artery and the catheterization was successful without any undesirable events. In the remaining 2 patients the left IJV was catherized using the same method. No complications related to the catheterization were observed. Our catheterization method is thought to be highly reliable and safe in small pediatric patients.

Anesthesia, General↗
PubMed1996

Infantile perianal pyramidal protrusion.

BACKGROUND: The number of reported cases of infantile perianal eruption has been increasing. However, infantile pyramidal protrusion located in the midline anterior to the anus has apparently been reported mainly as acrochordons or skinfolds. OBSERVATIONS: Fifteen infants (14 girls and 1 boy) had a pyramidal protrusion located only in the midline anterior to the anus. Histological examination revealed acanthosis in the epidermis, marked edema in the upper dermis, and mild infiltrates in the dermis. The patients had been brought to the hospital because of swelling of the protrusion. However, all protrusions showed reduction without any treatment. CONCLUSION: Infantile pyramidal protrusion located only in the midline anterior to the anus should be distinguished from acrochordons or skinfolds based on the characteristic clinical features.

Anus Diseases↗
PubMed1992

BCC-associated amyloidosis with a peculiar pattern of deposition.

An 83-year-old Japanese woman with lepromatous leprosy had been treated in a leprosarium. More than 10 years ago, she developed a dome-like brown tumor on the dorsum of the nose which showed the histology of basal cell carcinoma. The lesion was a well bordered, rounded tumor with tumor cell nests on its periphery extending toward the center as cords of tumor nest and with amyloid depositions between the cords. The tumor nests and amyloid lessened toward the center of the tumor, being replaced by collagen fibers. Amyloidosis showing this peculiar pattern of transition was reported with a review of published cases.

Aged↗
PubMed1991

Late onset dermal melanocytosis: an upper back variant.

Seven elderly Japanese men with blue macules on their upper backs are reported. Histological examination showed this pigmentation to be melanosis due to the presence of spindle-shaped or oval pigment-laden cells in the dermis. Electron microscopy revealed the cells to be compatible with dermal melanocytes. We assume that this condition belongs to the category of late onset dermal melanocytosis and is an upper back variant. This concept has not been proposed before.

Aged↗
PubMed1991

An unusual mechanical hyperkeratosis of the soles--health sandals keratosis.

A series of 13 patients with hyperkeratosis of both soles of the feet are presented. All patients developed hyperkeratosis after wearing the so-called "health sandals", which have multiple projections on their upper surfaces to stimulate the soles while walking. There was no evidence of hereditary or systemic factors producing the hyperkeratosis and it was concluded to be due to chronic mechanical stimulation of the soles. This side effect of the wearing of "health sandals" (health sandals keratosis) should be noted by dermatologists.

Adult↗
PubMed1991

Coexistence of spherulocytic disease (myospherulosis) and membranocystic degeneration.

A case of myospherulosis seen in a 22-year-old Japanese woman with lupus erythematosus is presented. Myospherules were found in subcutaneous nodules on the legs of the patient and were restricted to the areas of membranocystic change, a kind of degeneration of the adipose tissue. The myospherules were positive for blood group A antigens, suggesting a red blood cell origin. In contrast, the parent bodies of the myospherules were negative for blood group antigens. The coexistence of myospherulosis and membraneocystic changes has not been previously described, but might have been overlooked in the past.

Adult↗
PubMed1991

Spontaneous regression in Merkel cell (neuroendocrine) carcinoma of the skin.

In two Japanese women, 68 and 88 years old, Merkel cell (neuroendocrine) carcinoma of the face developed. Their tumors regressed after biopsy was performed, a rare occurrence. Histological and electron microscopic examination showed apoptosis, cellular necrosis, and an infiltration composed mainly of lymphocytes in the tumors. These changes may have been related to the mechanism of regression. It is interesting that our two patients were women, as was another patient described with Merkel cell carcinoma regression, in light of the fact that the prognosis of this tumor is sex dependent.

Aged↗
PubMed1990

Anticonvulsant syndrome with multiple symptoms, including porphyria, IgA deficiency, and liver dysfunction.

A 19-year-old Japanese female who had been treated for epilepsy with a combined phenytoin-phenobarbital preparation for the past three years presented with increasing skin pigmentation and hirsutism. She had suffered two attacks of loss of consciousness after bilateral partial oophorectomy at the age of 16. Investigations revealed a marked increase in coproporphyrin levels in the urine and feces, a marked decrease in her serum IgA level, and liver dysfunction. All these manifestations gradually improved upon the withdrawal of her antiepileptic treatment. In vitro studies revealed B cell dysfunction producing IgA deficiency, which normalized within one year after discontinuation of the antiepileptic therapy. It was assumed that her treatment had worsened preexisting porphyria, which was misdiagnosed as epilepsy because of abnormal EEG findings. The type of porphyria appeared to be hereditary coproporphyria, despite the lack of a family history.

Adult↗
PubMed1990

Protective effects of verapamil on ischemia-induced hepatic damage in the rat.

The preventive effects of the calcium channel blocker, verapamil, on ischemic liver damage were studied using a rat total hepatic ischemic model. A marked improvement in the survival was obtained by verapamil administration. Following 90 min of hepatic ischemia, 8 of 9 rats (89%) survived in the verapamil-treated group compared to only a 50% survival rate in the saline-treated control group. Furthermore, 56% of the rats still survived after 120 min of ischemia, while there was no survivor in the control group. The recovery of hepatic ATP level following ischemia was significant in the verapamil-treated group, showing the well-preserved mitochondrial function afforded by verapamil administration.

Adenosine Triphosphate↗
PubMed1989

Protective effect of prostaglandin E1 (PGE1) on energy metabolism and reticuloendothelial function in the ischemically damaged canine liver.

The protective effects of PGE1 on ischemia-related liver damage were evaluated in dogs. Ninety minutes warm hepatic ischemia was induced by the total clamping of hepatic inflow vasculatures with portal bypassing. The survival rate improved up to 62.5% when PGE1 was administered intravenously prior to ischemia, while no dog survived for longer than 1 week in the nontreated group. Hepatic ATP content was restored up to 80% of preischemic level 2 h after reflow in the PGE1 pretreated group, compared to 55% recovery in the nontreated group. Complete normalization of hepatic energy charge and rapid decrease of lactate were also seen in the PGE1 group. The clearance rate of intravascular lipid emulsion remained fairly normal in the PGE1 group, thereby suggesting well-preserved hepatic reticuloendothelial functions. The serum activities of beta-glucuronidase, GOT and GPT were suppressed in the PGE1-pretreated group, thereby implying a well-protected hepatic integrity. The histology revealed well-preserved hepatic architecture. The remarkable cytoprotective effect of PGE1 on hepatic ischemia shown in this study indicates that PGE1 warrants further study for protection of ischemically compromised hepatic allografts.

Adenosine Triphosphate↗
PubMed1986

Intrahepatic calculi associated with cholangiocarcinoma.

A unique case of hepatolithiasis associated with cholangiocarcinoma is described. The intrahepatic calculi consisted mainly of cholesterol rather than calcium bilirubinate. A bacteriological study of the intrahepatic and gallbladder bile was negative, though bacterial infection of the bile duct has been considered a main factor responsible for formation of intrahepatic calculi.

Adenoma, Bile Duct↗
PubMed1982

Improved white blood cell functions: additional effects of membrane plasmapheresis.

The changes in cellular functions were analyzed in 4 rheumatoid arthritis and 2 biliary cirrhosis patients. Impaired T-cell functions (low lymphocyte transformation reactivity (LTR) to Con A), seen in one cirrhosis patient before MP, improved with MP. MP also removed inhibitory factor(s) for LTR from the plasma of this patient. RA patients tended to have decreased Con A response and enhanced PWM response. MP enhanced LTR in 2 patients, but lowered LTR in patient who had been taking immunosuppressive drugs. Changes in lymphocyte populations occurred and included a substantial increase of T cells. A primary effect was an increase of helper T-cells. During MP, early leukopenia accompanied by complement activation and secondary leukocytosis were observed. Phagocytic PMNs activated by this process had significant augmentation of their O-2 generating activity as measured by chemiluminescence. This was evident in severe RA and in 2 cirrhosis patients with low phagocytic cell function before MP. This activation of phagocytes by MP may lead to additional beneficial effects by further lowering MMs such as immune complexes from plasma. A better understanding of these phenomena is necessary to assess the overall therapeutic response to MP, especially in patients where cellular mechanisms are important in pathogenesis of their disease.

Adult↗