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Biomedical subjects

K Kazuma

Publications and source records attributed to K Kazuma.

9 recordsLinked to original sources
PubMed2001

Mental adjustment to first recurrence and correlated factors in patients with breast cancer.

Previous reports have demonstrated that breast cancer patients felt that news of their recurrence was more upsetting than their initial diagnosis. However, no studies have examined the factors that are correlated with mental adjustment in breast cancer patients who experienced recurrence. The authors investigated factors that are correlated with mental adjustment styles of fighting spirit or helplessness/hopelessness in women with breast cancer with a first recurrence. Fifty-five participants were interviewed and completed the Mental Adjustment to Cancer scale. Factors that correlated significantly with fighting spirit were performance status and history of major depression, while factors that correlated significantly with helplessness/hopelessness were age, pain, and history of major depression. These findings suggest that it is necessary to provide intervention for first recurrent breast cancer patients who have such biomedical factors, as young age, poor performance status, pain, and history of major depression to help them better cope with cancer.

Adaptation, Psychological↗
PubMed2000

Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L.

The flavonoid constituents in fresh florets of the three distinctive cultivars of Carthamus tinctorius L. were purified and identified to investigate flavonoid biosynthesis in the petals. From the orange flower of cv. Kenba (K.), four new compounds, anhydrosafflor yellow B (1), two kaempferols, 9 and 13, and a quercetin, 17, were isolated, as well as the twelve known compounds, and their structures were determined by spectral data, chemical reactions, and molecular mechanics calculations. From the yellow flower of cv. Ogon-hanagasa (O.), two flavonols and two quinochalcones, and from the white flower of cv. Shiro-bana (S.), three flavonois were isolated. These compounds were the same as those contained in cv. K. To compare the flavonoid constituents among the three cultivars, crude extracts were analyzed by a LC/PDA/MS system. In cv. K., six quinochalcones and eleven flavonols were identified. In cv. O., three quinochalcones and nine flavonols were identified, but the red pigment, carthamin (4), and its precursor, precarthamin (3), were not detected. In cv. S., four flavonols without a 6-hydroxyl group were identified. On the basis of a comparative study on the constituents among these three cultivars, a possible biosynthetic pathway to form quinochalcones via the intermediate, pentahydroxychalcone (19), is proposed.

Asteraceae↗
PubMed1999

Utilization of the concentric circle model in clinical nursing: a review.

In this article, I review applications of the concentric circle model in clinical nursing. The concentric circle model is based on the cross-sectional shape of the body extremities at several points, and can be used in the areas of both kinesiology and nutritional science. This model makes it possible to calculate the cross-sectional area of muscles from measurement of the circumference of the extremities and the thickness of adipose (fatty) tissue. Then, changes in muscle strength or nutritional status can be inferred or assessed from these data. This model requires only simple and non-invasive measurements, and this is a significant and essential characteristic for its use by nurses, both in clinical and research applications.

Adipose Tissue↗
PubMed1998

177Lu-EDTMP: a potential therapeutic bone agent.

Lutetium-177 (177Lu) has both beta particle emissions for a therapeutic effect and gamma emissions for imaging. This study was undertaken to synthesize and evaluate 177Lu-EDTMP (ethylenediaminetetramethylene phosphonic acid) as a therapeutic radiopharmaceutical for the palliation of pain from bone metastases. Chelation of 177Lu to EDTMP was obtained by heating for 30 min in boiling water at pH 8.8, resulting in a radiochemical yield of over 99%. The compound was stable for 20 days without any appreciable dissociation. Biodistribution studies in normal rats indicated selective bone accumulation, showing faster blood clearance, higher bone uptake and higher bone-to-soft tissue ratios than 99Tcm-MDP. In conclusion, 177Lu-EDTMP has favourable biological and physical characteristics for the palliative treatment of painful bone metastases.

Animals↗
PubMed1993

[A study of changes in the nutritional status of patients receiving cancer chemotherapy].

In an attempt to find a method for effective nursing support which would maintain a favorable nutritional status in patients receiving chemotherapy, the nutritional status of 15 patients with lung cancer receiving cisplatin therapy was evaluated, and the factors influencing their status were studied. (1) Nutritional status was evaluated in terms of 7 indicators: body weight, skinfold thickness, arm muscle circumference, grip strength, hemoglobin level, serum total protein and serum albumin. Among these, skinfold thickness proved to be the most sensitive indicator of the changes in nutritional status of cancer patients during chemotherapy. (2) Multiple regression analysis revealed that skinfold thickness was influenced by dietary intake, which in turn was related to nausea, vomiting, trait anxiety level estimated by STAI and maximum body temperature associated with infection. (3) It was concluded that the following nursing interventions are significant for maintenance of favorable nutritional status for cancer patients during chemotherapy. First, periodic evaluation of their nutritional status by anthropometric measurements is necessary. Secondly, efforts should be made to reduce nausea and vomiting, to reassure patients with severe anxiety so that they become mentally stable, and to motivate the patients to perform self-care for prevention of infection, thereby achieving a sufficient dietary intake.

Cisplatin↗