Exercise-induced neurocardiogenic syncope.
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Adolescent↗
Biomedical subjects
K Kip
Publications and source records attributed to K Kip.
Postpartum syncope.
Recurrent unexpected syncope may have severe consequences and result in serious injury. This is especially the case in the immediate postpartum period when maternal syncope may have a disastrous effect on the infant as well as the mother. We report on 12 women who developed episodic hypotension resulting in syncope in the immediate postpartum period and describe the distinguishing characteristics of their presentation, tilt table results, and responses to therapy. Postpartum syncope represents a unique subgroup of syncopal patients who need to be recognized and treated in order to prevent potentially serious injury to both mother and infant.
1-Naphthylamine↗
Use of sertraline hydrochloride in the treatment of refractory neurocardiogenic syncope in children and adolescents.
OBJECTIVES: The purpose of our study was to determine whether the serotonin reuptake inhibitor sertraline hydrochloride could prevent neurocardiogenic syncope in children and adolescents resistant to or intolerant of other therapies. BACKGROUND: The serotonin reuptake inhibitor fluoxetine hydrochloride has been reported to be effective in preventing neurocardiogenic syncope in adults. METHODS: Seventeen consecutive young patients (mean age 15 years, range 10 to 18; 7 male, 10 female) with recurrent syncope and a positive head-upright tilt table test, and in whom standard therapies (fludrocortisone, transdermal scopolamine, beta-adrenergic blocking agents, disopyramide) were ineffectual, poorly tolerated or contraindicated, were referred for study. Sertraline was administered orally at 50 mg daily for 4 to 6 weeks. A head-upright tilt table test was then reperformed, and the clinical effect was noted. RESULTS: Three patients (18%, 95% confidence interval [CI] 1 to 44) were intolerant of the drug, and it was discontinued. Nine patients became asymptomatic and tilt negative (53%, 95% CI 26 to 76), and five remained tilt positive (36%, 95% CI 15 to 65). Over a mean follow-up period of 12 +/- 5 months, the tilt-negative patients remained symptom free while taking sertraline. CONCLUSIONS: The serotonin reuptake inhibitor sertraline hydrochloride can be effective in preventing recurrent neurocardiogenic syncope in selected patients unresponsive to or intolerant of other therapeutic modalities.
1-Naphthylamine↗
Head-upright tilt table testing in children with unexplained syncope.
Recurrent syncope in the young patient can be an anxiety-provoking experience that is often difficult to diagnose. Head-upright tilt table testing has emerged as a method for provoking episodes of vasodepressor syncope in predisposed individuals and thereby establishing a diagnosis. Currently indicated in the evaluation of young patients with recurrent unexplained syncope, it has also proven useful in differentiating convulsive syncope from epilepsy. Further studies will be needed to better define its role in the evaluation and management of recurrent syncope in children and adolescents.
Adolescent↗