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Biomedical subjects

K Kitamura

Publications and source records attributed to K Kitamura.

At least 1,261 records · Page 70Linked to original sources
PubMed1982

[Intracranial hematoma secondary to chronic DIC (author's transl)].

Five cases of intracranial hematoma secondary to chronic disseminated intravascular coagulation syndrome (DIC) were reported. Intracranial hematomas included a case of acute subdural hematoma combined with intracerebral hematoma and 4 cases of acute or subacute hematoma. Primary diseases which caused DIC were cancer; a case of carcinoma of choledochus and 4 cases of gastric carcinoma. All cases were in the advanced stage of carcinoma or at least, had metastasis to other organs. They showed coagulation disorders, such as, the reduction of platelets and the hemorrhagic diastasis, which were referred as chronic DIC, before the onset of intracranial hematoma. After the onset of intracranial hematoma, their coagulation disorders got worse and were diagnosed as acute DIC. They showed the rising of FDP, reduction of the serum fibrinogen and platelets and others. The blood transfusion and the trivial head injury were considered a triggers of exacervation from chronic DIC to acute DIC, that is, from compensated DIC to decompensated DIC. The long-term administration of anticancer drugs might play a part of the role as triggers. Initial symptoms of intracranial hematoma were headache in 4 case and dullness in a case. Three cases immediately lapsed into coma after 1 to 2 hours from the onset. Two cases turned out coma state after 4 to 5 days from the onset. Evacuations of hematoma were performed in 3 cases but they gave rise to rebleeding of intracranial hematomas later. All of 5 cases including surgically and non-surgically treated cases died at last. It is certain that DIC is rather common in the advanced stage of cancer. Matsuda reported that DIC existed in 20% of died patients with cancer. Though the incidence of intracranial hematoma secondary to DIC were less than that of cerebral infarct, it is no reasonable to assume that the actual number of the intracranial hematoma secondary to chronic DIC is rare.

Adult↗
PubMed1982

[A case of huge calcified chronic subdural hematoma].

In the literature, there has been no report of spontaneously growing calcified chronic subdural hematoma (C-C-SDH). The authors report a five-year-old boy with spontaneously growing C-C-SDH. The patient was admitted to author's department on July 24, 1979, because of progressive right hemiparesis, seizure and mental as well as physical retardation. He had a birth injury caused by forceps delivery resulting in skull fracture and subarachnoid hemorrhage. Three months after birth, gradual enlargement of his head circumference was noticed. A ventriculoperitoneal shunt was performed under the diagnosis of acute hydrocephalus. At the age of 17 months, he developed meningitis followed by right hemiparesis. When he was three years old, bilateral C-SDH was found on CT. The irrigation of hematoma was not successful because of the organization of hematoma. At the age of 4, calcification of the hematoma was found on CT and plain skull x-rays. Because of deterioration of the right hemiparesis, seizure and the enlargement of C-SDH, he was admitted to author's department on July 24, 1979. The left C-SDH was totally removed on August 10, 1979 by craniotomy. The extirpated C-C-SDH was 15 X 10 cm and 2 cm in thickness. Both inner and outer capsule were thick. The organized and partially calcified tissue was found between the two capsules. Sinusoidal blood vessels were also identified on the inner and outer capsules. Postoperatively, hemiparesis became improved. The second operation to the right C-C-SDH was performed from one year later after the first craniotomy. Surgical indication of C-C-SDH has to be determined on the basis of patient's age, symptoms and length of clinical course. It has been suggested that surgical treatment of C-C-SDH in children was not successful as compared with that in adults. The authors emphasize that C-C-SDH in children should be operated to encourage mental and physical development of the patients as well as to prevent hemorrhage and growth of C-C-SDH.

Calcinosis↗
PubMed1981

An alkaline metallo-proteinase in the human uterine cervix an changes in its activity by cervical ripening.

Human uterine cervix at term pregnancy was found to contain an alkaline metallo-proteinase by use of a synthetic substrate, 2,4-dinitrophenyl-L-Pro-L-Gln-Gly-L-Ile-L-Ala-Gly-L-Gln-D-Arg. The enzyme (with a molecular weight of 3.8 . 10(4)) was most active around pH 9.2 toward casein and N alpha-benzoyl-DL-Arg-rho-nitroanilide. [14C]-Gelatin and proteoglycan subunit were also substrates for the enzyme, but [14C]collagen was not. In particular, the enzyme digested gelatin 70-times faster than the novel neutral proteinase in the cervix. Although EDTA was a potent inhibitor, 1,10-phenanthroline, human serum, diisopropylfluorophosphate and elastatinal had no effect on the enzyme. Alkaline proteinase in term pregnant cervices was significantly higher than in non-pregnant ones.

Benzoylarginine Nitroanilide↗
PubMed1981

Neuroradiological manifestations of suprasellar pituitary adenomas, meningiomas and craniopharyngiomas.

The radiological manifestations of 16 pituitary adenomas, six meningiomas and 14 craniopharyngiomas were reviewed. The differential diagnosis of these tumors is possible with a few exceptions when skull radiography, CT, angiography and metrizamide cisternography are carefully evaluated. Prolonged injection angiography (PIA) is particularly important for demonstrating the contours of pituitary adenomas and meningiomas. Metrizamide cisternography is indicated when the tumor contours are obscure using PIA, or when the differential diagnosis is uncertain.

Adenoma↗
PubMed1981

Primary intracranial sarcomas: radiological diagnosis with emphasis on arteriography.

The radiological manifestations of primary intracranial sarcomas may be non-specific and they vary widely according to their histological variations. Reticulum cell sarcomas, however, can be included in the differential diagnosis with a high degree of reliability when one observes a hypovascular mass with arterial encasement and deep medullary veins. Tumor vessels and tumor stains supplied by dilated feeding arteries suggest the possibility of a sarcoma of the brain or of the meninges in infants. Nine reticulum cell sarcomas, four undifferentiated sarcomas, and one fibrosarcoma are presented here with their radiological manifestations, especially on angiography.

Adolescent↗
PubMed1981

Glial fibrillary acidic protein in medulloblastoma.

Twenty-four cases of classical medulloblastoma and one case of desmoplastic medulloblastoma were examined for glial fibrillary acidic protein (GFAP) using the immunoperoxidase method to assess astrocytic differentiation. In 16 cases of classical medulloblastoma GFAP-positive cells were present in variable numbers. These cells were classified as three different types according to size and shape. The type 1 cell was morphologically identical to the ordinary tumor cell, with a hyperchromatic nucleus and a scanty cytoplasm. The type 2 cell had a fairly rich cytoplasm with short cytoplasmic processes. The type 3 cell was characterized by a relatively large nucleus with sparse chromatin and well-developed cytoplasmic processes, and was considered a reactive astrocyte. The type 1 and some of the type 2 cells seemed to be neoplastic, displaying astrocytic differentiation. The remaining type 2 cells may have been reactive astrocytes. In one case of desmoplastic medulloblastoma, the majority of GFAP-positive cells were arranged in "islands", and had delicate fibrillated processes. GFAP-positive cells were also observed outside these "islands", though they were less numerous. Most of them were regarded as type 3 cells, but some were type 2. This may be interpreted as meaning that the glial character of the tumor was expressed more within than outside these "islands".

Adolescent↗
PubMed1981

Alternate culture and animal passage of human glioma.

The method of the alternate culture and animal passage was introduced in the study of human glioma. For animal passage the hereditary asplenicathymic (lasat) mice were used as a carrier. Because the lasat mice have practically no cellular and only little humoral immunity, the rate of tumor take was expected to be raised, and successful results were obtained. Ultrastructural and immunohistochemical (GFA protein) studies were also done. The overgrowth of stromal elements in reculture of tumors in lasat mice was less vigorous than in athymic nude mice. After four passages through lasat mice, an established well differentiated cell nests, and this alternate culture and animal passage suggested to enhance the differentiation and growth capacity. After three passages through lasat mice, the tumor line, KNS-42-L, produced tumors also in athymic nude mice and their histological features were essentially the same as those in lasat mice, and hence the lasat mice could be saved.

Animals↗
PubMed1981

Glycosylation of myelin glycoproteins in peripheral nerve via lipid intermediates.

Membrane preparations from chick peripheral nervous system (PNS) catalyzed the transfer of [3H]glucose from UDP-[3H]glucose into glucosylphosphoryl dolichol. The initial rate of glucosylphophoryl dolichol formation in a non-myelin membrane fraction from actively myelinating chick PNS was 11 fold higher than that from adult. Exogenous dolichyl monophosphate stimulated glucosylphosphoryl dolichol synthesis in both fractions. The higher level of glucosylphosphoryl dolichol synthesis corresponded to the onset of myelination in chick PNS. Exogenous dolichyl monophosphate also stimulated the labeling of glucosylated oligosaccharide lipids and glycoproteins in the fraction. On SDS polyacrylamide gel electrophoresis, the relative mobility of the major and minor radioactive glycoprotein corresponded with that of the P0 and PASII glycoprotein in PNS myelin, respectively. The results suggest that myelin glycoproteins in PNS are glycosylated via lipid intermediates.

Aging↗
PubMed1981

Anterior sacral meningocele discovered by whole body computerized tomography: case report.

A case of anterior sacral meningocele which was clearly visualized on whole body computerized tomography is presented. Posterior surgical approach with ligation of the narrow communication between the sacral dural sac and the meningocele alleviated the subjective complaints of a feeling of abdominal distention and of dysuria. For the purpose of postoperative follow-up study, examination by whole body computerized tomography proved to be the best method of evaluating the size of the meningocele and also the state of neighbouring structures.

Adolescent↗