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Biomedical subjects

K Kloss

Publications and source records attributed to K Kloss.

At least 19 recordsLinked to original sources

Characterization of deletions at the retinoblastoma locus in patients with bilateral retinoblastoma.

DNA samples from 92 unrelated patients with bilateral retinoblastoma were analyzed by Southern blot hybridization with cDNA and genomic clones of the retinoblastoma (RB-1) gene. Qualitative and quantitative evaluation of the Southern blot patterns showed a deletion of all or part of the RB-1 gene in 15 patients. Deletion hot spots were not detected. The study shows that 16% of germ cell mutations are detectable by Southern blot hybridization, but that densitometric analysis is required in most cases.

Blotting, Southern↗

Chronic inflammatory polyradiculoneuropathy complicated by factor VIII antibody.

A 66-year-old man with a 45-month course of chronic inflammatory polyradiculoneuropathy developed a coagulopathy due to an antibody to factor VIII. Despite clinical improvement in the neurologic disease at the onset of the coagulation disorder, antibody to peripheral nerve myelin was demonstrated in high titer. Antibodies to factor VIII and peripheral nerve myelin were both of the IgG class, but were immunologically distinct. This previously unreported association lends further credence to a disturbance in immunoregulation in chronic inflammatory polyradiculoneuropathy.

Aged↗

[Neurosurgical aspects of the apallic problem].

In the period from 1965 to 1974, 77 patients with an apallic syndrome were observed at the Surgical University Clinic of Innsbruck. Main cause was cerebral contusion (35 patients) followed by open fracture of the skull (7), acute subdural haematoma (7), aneurysm (7), epidural haematoma (6), cerebral tumours (4), perforating skull lesion and traumatic intracerebral haematoma (2 each). 43 patients died, 5 showed spontaneous healing and 9 a rehabilitation effect. Defect healings occurred 12 times. For 23 patients, the survival times were up to 3 months and for 4 patients one year. Patients with healed defects were followed up for more than 10 years. The calculation of the nursing costs as compared to a simple surgical case showed an eight times higher value. However, the financial expenditure for drugs and laboratory findings decreased considerably from about the forth week. The large amount of nursing means and the high cost for personnel remained. Of the 285 patients of the years 1965 to 1974, who were unconscious during a period of up to one week, 59 became apallic. Of these, 27 survival, three were healed, 8 in rehabilitation, 5 as permanent nursing cases and 2 as defect healing. No clinical or intrumental methods can be found by means of which a prediction is possible whether the patient will be healed or become will develop an apallic syndrome.

Adolescent↗

[Stab wounds of the brain. A case report (author's transl)].

The case history is presented of a 10-year-old boy who stabbed himself accidentally during play with a knife which penetrated deep into the temporal lobe of the brain via the orbit. The child was fully conscious on admission to hospital without any obvious neurological signs. The knife was removed surgically and the immediate postoperative findings of ptosis, chemosis and slight restriction of movement of the left eye regressed rapidly.

Angiography↗