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Biomedical subjects

K Kohlmeyer

Publications and source records attributed to K Kohlmeyer.

At least 37 records · Page 2Linked to original sources

Comparative studies of computed tomography and measurements of regional cerebral blood flow in stroke patients.

Comparative studies of computed tomography and of regional cerebral blood flow (rCBF) by means of the intracarotid xenon-133-clearance method were performed in 25 stroke patients. The relationships between an infarction in CT and disturbances of rCBF, between a normal CT in stroke cases and focal changes of CBF, and between the luxury perfusion syndrome in the rCBF study and contrast enhancement of an infarct in CT are demonstrated and discussed.

Brain↗

[Bony malformations of the cranio-vertebral junction and its clinical relevance (author's transl)].

A statistical analysis is performed in 86 cases suffering from osseous malformation of the cranio-vertebral junction. The material consists of 71 cases with basilar impression, 8 cases with hypoplasia or absence of the odontoid process, and 7 cases with a congenital atlanto-epistropheal dislocation. The patients are clinically asymptomatic in 23 cases, and are marked by a para-respectively tetraparesis in 28 cases, by bulbar-pontine-cerebellar disorders in 24 cases, and by syringomyelia in 11 cases. A control group is included consisting of 30 cases without neurological symptoms and with a normal radiological finding of the cranio-vertebral region. The following measured values are taken in consideration to perform a statistical calculation using the simple variance analysis: The height of the odontoid process above of McGregor's line, the distance between the back of the odontoid process and the inner limit of the arch of C1, and, concerning the groups with hypoplasia of the odontoid process process and with atlanto-axial dislocation, the narrowing of the spinal canal at the level of C1 dependent on movements of the head. The measured values are referred to the different clinical syndromes and are described and divided according to its statistical significance related to the clinical groups.

Adolescent↗

[Vincamine concentrations in plasma and cerebrospinal fluid in patients following intravenous infusion (author's transl)].

The pharmacokinetic characteristics of 14,15-dihydro-14beta-hydroxy-(3alpha,16alpha)-eburnamenine-14-carbonic acid methylester (vincamine; Vincapront) were studied after i.v. infusion (30 or 40 mg vincamine-hydrochloride within 28--40 min, respectively) in 6 patients with cerebrovascular diseases. At the end of the infusion, maximum plasma levels ranged between 607 and 999 ng/ml. The decline of the plasma concentrations after the end of the infusion could be described using a two-compartment open model. After a phase of distribution lasting 1--2 h there was a linear elimination of vincamine in the semilogarithmic plot. The mean half-life for the beta-slope was 2 h. In four patients we measured the vincamine concentration in the cerebrospinal fluid 2 h after the end of the infusion. It amounted to only 5--24% of the simultaneously estimated plasma concentration.

Adult↗