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Biomedical subjects

K Kokkola

Publications and source records attributed to K Kokkola.

At least 19 recordsLinked to original sources
PubMed1977

Potentiation of beta-sympathomimetics with alpha-adrenoceptor blocking drugs in guinea pig trachea and human bronchus preparations.

The actions of beta-sympathomimetics alone and in various combinations with alpha-adrenoceptor blocking agents were studied in guinea pig tracheal chain and in some preparations of human bronchi taken in operations. All the alpha-adrenoceptor blockers caused 50-100% potentiation of the effects of the beta-sympathomimetics studied in both preparations, had no effects of their own in the rather low concentrations used (10(-10) --10(-6) mol/l). The results show that guinea pig and human tracheobronchial smooth muscle react similarly to these drugs and may contain adrenergic alpha-receptors.

Adrenergic alpha-Antagonists↗
PubMed1977

Electrocardiographic low-frequency QRS notching and ventilatory impairment in patients with pulmonary tuberculosis.

The occurrence of notching in the initial and terminal parts of the QRS complex of the ECG was studied in a series of 1072 patients with active or healed pulmonary tuberculosis. Terminal notchings were associated with ventilatory impairment: in the male group the percentage of patients with terminal notching increased from 5 to 20% as the FEV1.0% decreased from larger than or equal to 80 to below 40. Initial notchings were not associated with ventilatory impairment. The relationships were similar when studied separately in groups with and without left heart disease.

Electrocardiography↗
PubMed1975

Pulmonary function in tetraplegic and paraplegic patients.

Dynamic spirometry and arterial blood gas analyses were performed in a series of 12 tetraplegic and 8 paraplegic patients. A marked restrictive impairment of ventilatory function was found in all patients with tetraplegia, the mean vital capacity (VC) and one second forced expiratory volume (FEV1.0) were less than half of the predicted normal values. Paraplegia was accompanied only by a slight ventilatory restriction in five patients, while three showed normal respiratory function. Signs of airways obstruction were not revealed in either group. Arterial oxygen tension was normal in all patients. With one exception, elevated PaCO2 values were not found in the series. Hyperventilation (decreased arterial PCO2) was a common finding, it was regarded to be partly due to the effects connected with the examination procedure.

Adolescent↗
PubMed1975

Broncholithic casts. A case report.

A case of multiple broncholithic casts is reported. The diagnosis was made on clinical and radiological findings without histological verification. Tuberculosis was regarded as the probable cause.

Bronchial Diseases↗
PubMed1975

Inactive pulmonary lesions: a potent risk factor of tuberculosis.

Case histories and previous chest X-ray films of 142 patients with bacteriologically confirmed active pulmonary tuberculosis from eastern Finland were re-examined. In 18% of the series the disease was a reactivation of previously diagnosed and treated tuberculosis. In 70% of the patients with first clinical attack of tuberculosis, previous RP-films revealed fibrotic lesions in the lungs. Only 23% of the whole series had no previous abnormality on chest X-ray examination or previous clinical tuberculosis. Fibrotic pulmonary lesions are therefore a significant risk factor in the epidemiology of pulmonary tuberculosis, which has been given too little attention.

Adolescent↗