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Biomedical subjects

K Kokubun

Publications and source records attributed to K Kokubun.

26 records · Page 2Linked to original sources
PubMed1984

[Clinical evaluation of cefmenoxime in internal medicine, with special reference to infections associated with hematological disorders].

Clinical evaluation of cefmenoxime (CMX, Bestcall) was examined in the infection associated with hematological disorders, respiratory tract and other disorders. Clinical effectiveness for severe infection of hematological disorders was 47.4% in good and 84.2% in fair response, however, in the respiratory tract infections, 89.7% in good response was obtained. Opportunistic infection due to Gram-negative bacilli are often experienced in patients with hematological disorders. It was discussed that CMX would be a good therapeutic agent against infectious diseases associated with hematological disorders because it's antibacterial spectrum would be parallel to pathogens of such disorders.

Adolescent↗
PubMed1983

The effect of acute inflammation on iron metabolism in rats.

Iron metabolism in rats with acute turpentine-induced inflammation was evaluated. In acute inflammation, reduced plasma iron and total iron-binding capacity values, shortened plasma iron disappearance time and lower plasma iron turnover were observed. The administration of 59Fe chondroitin ferrous sulfate in order to evaluate the reticuloendothelial (RE) function revealed a significantly increased 59Fe retention in the liver and lower incorporation into red blood cells. Radioactivity in hepatic RE cells was higher in acute inflammation than in control. These results suggest the possibility of a block in the transfer of iron from RE cells to the plasma iron pool during acute inflammation.

Animals↗
PubMed1983

[Anatomical and clinical study on the femoral nerve lesion].

Neuralgic and paralytic symptoms due to lesions of the femoral nerve or its related nerve roots are not infrequently encountered and therefore, clinically important. In order to clarify their pathomechanism the author has done anatomical, kinesiologic, and clinical studies. The topographic course of the femoral nerve was carefully observed in 40 cadavers (80 nerves) and transverse sections of 4 cadavers cut horizontally at various levels. The interrelation between the nerve and its surrounding organs was thus analysed. The 81 cases (87 nerves) of femoral nerve lesion, including lumbar radiculopathy, femoral neuropathy, and saphenous nerve lesion, were clinically followed up and the mechanism of their production was analysed. Besides, kinesiologic studies using electromyograms of the trunk and lower extremity muscles were performed in 8 cases (9 lesions) and 20 normal male controls. The main results obtained are as follows: 1. From the embryologic and morphologic points of view, the femoral nerve runs a peculiar course and has characteristic shapes in its transverse sections at various levels. 2. As the nerve lies closely adjacent to several pelvic organs, it can easily be influenced by their pathological conditions. 3. When the adjacent organs are treated surgically, it may be rare that the nerve is injured, constituting a complication. 4. The pathomechanism of the femoral neuropathy occurring at the inguinal ligament is quite similar to that of entrapment neuropathy of the peripheral nerve that occurs at a fibro-osseous tunnel. 5. Even if the quadriceps femoris muscle is totally paralysed, extention of the knee joint is possible to some extent because of a compensatory action of the tensor fasciae latae muscle.

Adult↗