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K Komeda

Publications and source records attributed to K Komeda.

45 records · Page 3Linked to original sources
PubMed1984

Mandible analysis of NOD and NON strains of mice.

10 inbred strains of mice including NOD and NON were identified by discriminant and canonical discriminant analysis of the mandible measurements. The number of erroneous discriminations was 0.5% (1/199) for the females and 0% for males (0/232). In canonical discriminant analysis (discriminant analysis with reduction of dimensionality), NOD and NON inbred strains were separately located on 2-dimensional planes, Z1-Z2, Z1-Z3, and Z2-Z3. These results clearly indicate that the genetic constitution of NOD and NON differs, although they have been established from a common ancestor ICR mouse. Causes of divergence between NOD and NON mice are discussed.

Analysis of Variance↗
PubMed1984

Plasma progesterone concentrations during the estrous cycle, pregnancy, and lactation in the Chinese hamster, Cricetulus griceus.

From vaginal smear and histological observations, Chinese hamster (Cricetulus griseus) exhibited four day estrous cycles and had a gestation period of 20 days. The concentrations of progesterone fluctuated in a biphasic pattern during the estrous cycle with peak values at diestrus and proestrus. The levels of the hormone increased approximately threefold from day five to day eight of gestation, remained elevated until parturition, and then fell precipitously during lactation to levels on day zero of gestation.

Animals↗
PubMed1982

Genetic relationships among 5 inbred strains established from common ancestor, dd mouse, as assessed by mandible analysis.

By multivariate analysis using mandible measurements genetic relationships were investigated among 5 inbred strains, DDD, DDK, DSD, DD/Tbr and DDY, derived from the common ancestor, dd mouse. (1) In canonical discriminant analysis (discriminant analysis with reduction of dimensionality), 3 DD strains, DDD, DSD, and DDY, were closer to one another than to any control strain on planes Z1-Z2, Z1-Z3, and Z2-Z3. Only the DDK strain was quite far from those 3 strains. (2) In the discriminant analysis, however, the 5 inbred strains could be classified correctly at the rate of 100%. They were genetically different from one another. (3) The causes for this genetical difference seemed to be the genetic heterogeneity of the ancestor dd mouse and the method of inbreeding which had been independent since the separation.

Analysis of Variance↗
PubMed1981

Genetic relationships between sublines of inbred strains of mice as assessed by mandible analysis.

Genetic relationships between sublines of inbred strains of mice were investigated by using mandible measurements. (1) Canonical discriminant analysis (discriminant analysis with reduction of dimensionality) was applied to the investigation of genetic relationships between sublines on two kinds of dimensionality. As a result, it was made clear that all the sublines of the same strains mapped closer to each other than they were to other strains on the plane of z1--z2, except the sublines of strain AA. (2) According to the result of discriminant analysis, misclassification among the sublines of the other strains was only 0 head/302 head, or 0%, for the male mice and 6 head/302 head, or 1.99%, for the female mice. Misidentification between the sublines of the same strain was also of low rate; that is, 28/302, or 9.27%, or the males and 9/302, or 2.98%, for the females. These results suggested that the mice of the sublines of the same strain might be genetically different from one another. (3) The cause for the occurrence of such subline divergence as this seemed to be mainly due to the spontaneous mutation of each colony after the separation of mice. It appeared that the subline divergence of strain AA might be due to the genetic heterozygosity of an original stock before the separation of mice.

Animals↗
PubMed1980

Diabetic syndrome in the Chinese hamster induced with monosodium glutamate.

Neuronal necrosis in the arcuate and ventromedial hypothalamus regions is easily induced in 1-day-old Chinese hamsters by the administration of monosodium glutamate (MSG). New-born Chinese hamsters injected with MSG showed no sign of obesity, even when grown up, but apparently developed a diabetic syndrome.

Animals↗
PubMed1977

[Clinical experience with S-6436 in patients with urinary tract infections (author's transl)].

Forty eight patients with urinary tract infections including a case of acute prostatitis were treated with S-6436 and the following results were obtained: 1. Thirty eight patients with acute cystitis resulted in 19 excellent, 15 good and 4 poor with effectiveness rate of 89.5%. 2. Ten patients with complicated urinary tract infections resulted in 1 excellent, 5 good and 4 poor with effectiveness rate of 60%. 3. Infecting organisms from 38 patients with acute cystitis were occupied by 28 strains of E. coli. The sensitivity rate of the infecting organisms to cephalexin was 96.4%. 4. In a few cases (6.25%) side effects of S-6436 were observed. 5. S-6436 will be one of the good first choice antibiotics for acute cystitis.

Acute Disease↗
PubMedDate not supplied

Administration of optimum sustained-insulin release PLGA microcapsules to spontaneous diabetes-prone BB/Wor//Tky rats.

To show the possibility of sustained-release insulin formulation composed of PLGA, the optimum one was administered to BioBreeding rat, a model of spontaneous type I diabetes mellitus (IDDM). Every 2 weeks subcutaneous administration made their blood glucose level depend on the insulin release and food intake. However, all of them kept alive with little change or rather a little gain in body weight. Furthermore, some of pregnant rats with intermittent treatment bore fetuses, although additional insulin therapy seemed necessary. Therefore, the formulation could become a new tool as a provider of basal insulin for IDDM patients.

Animals↗