[Clinical usefulness of cyto-oncologic examination of the cerebrospinal fluid].
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to K Kos-Lis.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
In the cerebrospinal fluid and serum the activity was determined of phosphocreatine kinase (CPK), lactic dehydrogenase (LDH), aspartate transaminase (AspAT) and alanine transaminase (AlAT) in 107 cases of multiple sclerosis. The results were compared with those in a control group of neurosis and a highly significant (three times) increase was observed in the activity of CPK and LDH in the cerebrospinal fluid as a result of organic damage to the brain tissue. By chromatographic method direct data were obtained indicating that increased CPK activity in the cerebrospinal fluid was connected with the CK-BB isoenzyme, that is with the cerebral fraction of the enzyme.
We report four patients who had multiple sclerosis associated with diabetes mellitus. Multiple sclerosis and diabetes mellitus share clinical, epidemiological and immunological features. The association between these two putative autoimmune diseases may suggest a similar pathogenic mechanism.