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Biomedical subjects

K Kosari

Publications and source records attributed to K Kosari.

2 recordsLinked to original sources

The biomechanical efficacy of an oscillating K-wire driver.

A new oscillating drill, designed for insertional ease and safety, was biomechanically tested using an MTS 812 servohydraulic material testing machine (Instrom). Holding strength and drilling force were compared against a traditional rotary drill using rabbit tibias to approximate the diameter and cortical thickness of human metacarpals. Three differently sized (0.028-, 0.045-, and 0.062-in. diameter) K-wires were evaluated for each drill. Mean peak axial load (drilling force) was significantly different for each wire driver type in each of the three sized K-wires (p < or = 0.01). The oscillating drill used an average of 3 N less force to penetrate either cortex. Mean peak pull-out force (holding strength) was higher for the oscillating drill, but the difference was not significant (p > or = 0.5). This study indicated that the oscillating drill required less force for insertion and had a similar holding strength as the rotary drill. In addition, our drill has been shown to be less damaging to surrounding soft tissues. This new type of drill is likely to be advantageous in the fields of hand, microsurgery, orthopedic, and plastic surgery, where bone fixation is often near vital neurovascular structures.

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Demineralized bone matrix polydioxanone composite as a substitute for bone graft: a comparative study in rats.

Demineralized bone matrix (DBM) has been successfully used as a substitute for bone grafting. Autogenous bone grafts (ABG) may cause donor site morbidity and undergo significant resorption. DBM may overcome these problems but is mechanically unstable when originally placed. We explored using a slowly resorbable template, polydioxanone (PDS), in combination with DBM and compared it to ABG in a rat 9 x 9 mm cranial defect model. After both 1 and 3 months, histologically and biochemically well-formed bone was present in ABG/PDS and DBM/PDS-treated defects, but not in control defects (PDS alone). Mechanical push-out tests using a servohydraulic testing frame were conducted. Maximum load before failure of DBM/PDS increased from 65% at 1 month to 100% of that of intact skull at 3 months. In contrast, ABG/PDS was 50% as strong as DBM/PDS and not significantly stronger than PDS alone. ABG/DBM did not significantly increase in strength from 1 to 3 months. We conclude that DBM/PDS is better than ABG/PDS in treating cranial defects in the rat model, and that an absorbable osteoinductive bone substitute with superior mechanical advantage is possible without the disadvantages of ABG.

Animals↗