PubMed Health⌕ Search

Biomedical subjects

K Koutoulidis

Publications and source records attributed to K Koutoulidis.

5 recordsLinked to original sources
PubMed1991

Size of the pancreas in non-insulin-dependent diabetic patients.

We investigated the relationship between the size of the pancreas in non-insulin-dependent diabetic patients (NIDDs) and normal subjects, and also the possible correlation between pancreatic size in diabetics and basal C-peptide concentrations. Eighty-four non-insulin-dependent diabetics and eighty control subjects matched for age, sex and body mass index (BMI) were studied, using a realtime sector system, with which we measured the head and body of the pancreas in cm2. Scans were performed twice in 50 subjects with no significant difference. Both the head and the body of the pancreas were significantly smaller in diabetics (4.60 +/- 1.10 cm2, 5.92 +/- 1.53 cm2, respectively) than in normal subjects (6.09 +/- 1.62 cm2, 7.43 +/- 2.14 cm2) (p less than 0.001). The mean total area of the pancreas for the diabetics was 10.53 +/- 2.45 cm2, and for the controls 13.53 +/- 3.60 cm2 (p less than 0.001). No correlation was found between the total area of the pancreas and the BMI in the two groups. In the diabetic group, there was a positive correlation between C-peptide and the total area of the pancreas (r = 0.30, p less than 0.01). We concluded that the size of the pancreas is smaller in NIDDs than in healthy controls, and there is a positive correlation with the basal C-peptide concentration.

C-Peptide↗
PubMed1990

Elevated serum levels of angiotensin-converting enzyme in patients with diabetic retinopathy.

Serum levels of angiotensin-converting enzyme (ACE) were measured in 53 patients with type II (non-insulin-dependent) diabetes (25 without ophthalmologic complications, 20 with background retinopathy, and eight with proliferative retinopathy) and in 33 healthy nondiabetic subjects. Diabetic subjects were excluded if they had hypertension, ischemic heart disease, peripheral vascular disease, or an elevated urine albumin level. After an overnight fast, blood was taken for determination of ACE, blood glucose, glycosylated hemoglobin (HbA1), and C peptide levels. Data were analyzed according to the nonpaired Student's t test and linear regression analysis. Levels of ACE were significantly elevated in the whole diabetic group as compared with control subjects (334.0 U/L +/- 97.0 vs 250.5 U/L +/- 85.5, P less than .001). This elevation was more marked in those diabetics with background retinopathy (344.6 U/L +/- 96.8, P less than .001) and proliferative retinopathy (357.3 U/L +/- 93.2, P less than .01); no significant difference was found between ACE levels of diabetics without complications and those of control subjects. No correlation was found between ACE levels and HbA1, blood glucose, or C peptide values. We conclude that ACE levels are elevated in type II diabetes, chiefly in patients with retinopathy. This finding may reflect microvascular damage caused by secretion of ACE by the vascular endothelial cells.

Blood Glucose↗
PubMed1989

Correlation between high density lipoprotein cholesterol and C-peptide in sulfonylurea-treated diabetic patients.

The aim of this study was to assess the possible relationship between high density lipoprotein cholesterol (HDL-C) concentrations and endogenous insulin secretion, as measured by basal serum C-peptide secretion. Eighty-nine non-insulin-dependent diabetic patients (NIDDs) being treated with sulfonylureas were studied. There were 47 men and 42 women matched for age, body mass index (BMI), duration of diabetes and glycemic control. Blood samples were taken after an overnight fast. HDL-C concentrations were significantly lower in males (45.9 +/- 11.2 mg/dl) than in females (52.9 +/- 13.1 mg/dl) (p less than 0.01). There was a negative correlation between C-peptide and HDL-C (males r = -0.40, p less than 0.01; females r = -0.42, p less than 0.01), and a positive correlation between C-peptide and serum triglyceride (Tg) (males r = +0.36, p less than 0.05; females r = +0.31, p less than 0.05).

Aged↗
PubMed1979

How do tears drain? Technetium studies.

We examined the tear drainage system of twenty-fiv normal volunteers by scintillography with Technetium Tc 99m (Pertechnetate). We photographed the changes occurring in the lacrimal sac and nasolacrimal duct during closure and opening of the eyelids. Our findings support Jones' views of normal tear drainage. The tracer was concentrated in the lacrimal sac while the lids were closed for 3 minutes and descended into the nasolacrimal duct as soon as they opened.

Eyelids↗