Biomedical subjects

K Kovacheva

Publications and source records attributed to K Kovacheva.

11 recordsLinked to original sources

PubMed2006

[Terminated pregnancy following prenatal diagnosis of congenital anomalies--a part of register of congenital anomalies].

UNLABELLED: The most of European registries of congenital anomalies (CA) collected information of CA in livebirths, stillbirths and terminated pregnancies following prenatal/ultrasound diagnosis. OBJECTIVES: to assess terminated pregnancies after prenatal/ ultrasound diagnosis of CA as a part of register of CA performed in University Hospital-Pleven. Among 21 202 births monitored during the study period (1996-2005), 679 CA were detected. The total prevalence of CA was 32/ 1000 births. The outcome of pregnancy for all cases of selected CA by register was 620 livebirths (91.3%), 36 stillbirths (5.3%), 23 terminated pregnancies (TP) (3.4%). The percentage of pregnancy termination was higher in the case of isolated anomalies, mainly lethal and CA associated with a low survival rate (61%), than with multiple ones. The most common CA detected after prenatal/ ultrasound diagnosis were neural tube defects (NTD) - the main reason for TP (52% of cases). The low proportion of these CA in TP (1/3) compared to their proportion in livebirths (50%) demonstrated an insufficiency of prenatal diagnosis of NTD as a part of register of CA performed in University Hospital-Pleven. Prenatal diagnosis of CA allows an early genetic counseling of mother presenting information on neonatal prognosis and recurrence risk for subsequent pregnancies. It helps family to take an adequate decision for termination of pregnancy with bad prognosis about heavy fetal CA.

Abortion, Induced↗

PubMed2004

[Active screening for genetic pathology in newborns. I. Registration of congenital abnormalities].

Active screening for genetic pathology over a period of 12 years (1990-2001) involved examination of 29,629 newborns at the Clinic of Obstetrics and Gynaecology. Congenital anomalies were detected in 1244 cases (live-, stillbirths and terminated pregnancies) which gives an average incidence rate of 42.0 per 1000 among the studied population. Congenital cardiac anomalies and CA of the central nervous system were the most common types of isolated CA. They provided frequencies of 7.76 per 1000 and 6.85 per 1000 cases respectively. The incidence of the neural tube defects (NTD), particularly, varied throughout the years (t = 2.69; p < 0.01) but stated high--on average 2.12 per 1000 with the highest rate of 3.89 per 1000 in 1993. A reduction in the incidence of NTD is possible with a recommendation of periconceptional folic acid supplementation. Registration of CA is a strategy for identifying families at risk to give births of child with CA. This approach enabled us to provide more accurate genetic counselling and prenatal diagnosis for genetic pathology. Active screening of newborn population is likely to be an effective and necessary service.

Bulgaria↗

PubMed2004

[Active screening for genetic pathology in newborns. II. Genetic counseling and prenatal diagnosis in high risk families].

Active screening for genetic pathology over a period of 12 years (1990-2001) involved examination of 29629 newborns at the Clinic of Obstetrics and Gynaecology. Congenital anomalies were detected in 1244 cases (live-, stillbirths and terminated pregnancies) which gives an average incidence rate of 42.0 per 1000 among the studied population. Chromosomal abnormalities were diagnosed in 70 cases (5.6%), single gene conditions--in 164 cases (13.2%), multifactorially determined conditions--in 449 cases (36.1%). The total genetic contribution of all recognized cases with genetic conditions was 54.9% (683 cases). Genetic counseling was provided to 560 out of 1244 (45%) couples who given births to affected children. During that period prenatal diagnosis was performed on 110 (44%) pregnancies and most of them (90%) ended successfully (healthy child was born). Our strategy for identifying CD by active screening enabled us to provide more accurate genetic counselling and prenatal diagnosis for genetic diseases. Screening of newborn population is likely to be an effective and necessary service.

Bulgaria↗

PubMed2001

Biostimulation-based bioremediation of diesel fuel: field demonstration.

Ex-situ bioremediation of leached cynamonic forest soil at initial diesel oil contamination of 6,000 mg kg(-1), 4,000 mg kg(-1) and 2,000 mg kg(-1) was investigated after biostimulation with inorganic fertilizers. It was found that the added nutrients had no effect on the decontamination of polluted soils. A precise and reliable approach for evaluation of the biodegradation process is proposed. It comprises application of sensitive and easily accessible diagnostic parameters and relations, calculated on the basis of n-alkanes and isoprenoids--pristane (2.6.10.14-tetramethylpentadecane, i-C19H40) and phytane (2.6.10.14-tetramethylhexadecane, i-C20H42) distribution.

Alkanes↗

PubMed2001

[Osteogenesis imperfecta - diagnostic challenges].

Osteogenesis imperfecta (OI) is one of the commonest skeletal disorders with an incidence about one in 10,000. It is characterized by clinical and genetic heterogeneity. Congenital lethal OI (OI type II) is the most severe from with a possibility of the early prenatal sonographic diagnosis. The authors present two clinical cases of antenatal diagnosis of OI in 26 and 24 weeks of gestation. The pregnancies were terminated. The accurate specific diagnosis was based on the clinical examination and radiographic features. In case N 2 additional findings were ascites and hydrothorax, that may occasionally be found in literature. The accurate prenatal sonographic diagnosis of lethal skeletal dysplasias and particularly of OI is possible and based on the specific sonographic findings during the second trimester of pregnancy. Ultrasound screening of all pregnant women in early second trimester is an efficient method for detection of many fetal malformations. It requires a participation of the both clinician sonographer and geneticist in a team in order to achieve a specific genetic diagnosis.

Abortion, Induced↗

PubMed2000

[Congenital anomalies among live-birth infants and their place in the structure of neonatal mortality--the Higher Medical Institute, Pleven (1993-97)].

The aim of the study was to determine the frequency of the congenital anomalies (CA) among the live-born (LB), the structure of the neonatal mortality (NM) and the impact of congenital anomalies on it. Congenital anomalies were found in 171 (2.71%) of 11,902 infants born and hospitalized at the Clinics of Neonatology--Pleven between 1993 and 1997. 171 (14.4% o) of all LB died in 28 day after delivery. Noninfectious lung pathology and CA were responsible for respectively 28.7% and 27.5% of these deaths and were the main causes of NM. Multiple congenital anomalies and CA of cardio-vascular system were the most frequent CA that caused these deaths. The major part of the CA with genetic basis (64%) emphasizes the importance of the registration of CA and the genetic counselling for declining the NM rate.

Bulgaria↗

PubMed1998

[Postnatal screening for congenital anomalies--the possibility of detecting families at high genetic risk].

The aim of the study was to present out experience with the registration of congenital anomalies (CA) and to assess the effect of the preventive genetic-consultative activities in affected families. In the period 1990-1996, 19174 infants born or hospitalized at the Clinic of Obstetrics, Pleven were screened for CA, showing frequency of 26.1%. Structural analysis of the CA is presented. 226 out of 500 (45%) families with and affected child were consulted by a geneticist. Data an prenatal diagnosis (PD) offered to 142 families at high risk and their reproductive decision are submitted. The low rate of families made use of invasive PD is pointed out; the real benefits of ultrasonography as a screening test for detection of fetal anomalies has been recommended.

Abnormalities, Multiple↗

PubMed1996

[The testicular feminization syndrome combined with disseminated hemangiomatosis].

It is described a new born child with many hemangiomas on the liver. It is made a karyogram to exclude. The possibility of chromosome disease. We fixed male karyotype 46 XY--syndrome Morris. We found out that it is a rare combination of testicular feminization with disseminated hemangiomatosis. After the medical treatment with high doses of cortisone the hemangiomas decreased their sizes.

Androgen-Insensitivity Syndrome↗

PubMed1995

[The role of chromosome anomalies in the origin of reproductive failures].

The results from chromosomal analysis of 185 couples, studied on the occasion of reproductive failures (RF), such as sterility, spontaneous abortions, stillbirths and malformed children are presented. Twenty nine couples (15.68%) with one of spouses--a carrier of a chromosomal anomaly (CA) are established. CA types include: aneuploidy--2, mosaic--5, Robertson's translocation--3, non-Robertson's translocation--7, and pericentric inversion--12. Recognition of genetic conditions is vital for accurate assessment of recurrence risks and in order in some instances, to provide specific prenatal diagnosis.

Abnormalities, Multiple↗

PubMed1978

[Effect of aflatoxin on the serum profile and antibody formation in chickens].

Experiments were carried out to follow up the effect of aflatoxin on the production of hemagglutinating antibodies in birds vaccinated against Newcastle disease and the changes in the serum profile. Birds that had been given a feed mixture with 560 and 640 mcg per kg for 20 days showed a lower titer of hemagglutinating antibodies and a drop of the alpha1, alpha2, beta1, gamma2-globulin fractions as well as a rise of the albumin and gamma1-globulin fractions. The liver and kidneys of the treated birds showed dystrophic changes.

Aflatoxins↗

PubMed1975

[Some properties of cytophil antibodies against the O-antigen of Salmonella abortusovis].

Boyden's multilayer method was made use of to study the resistance to mercaptoetanol, and to temperature effects as well as the fixation capacity of macrophages of other animal species as regards cytophil antibodies from sera of guinea pigs immunized with a live culture of Salmonella abortusovis. It was found that they are resistant to heating at 56 degrees C for 30 minutes, to mercaptoetanol, and are not fixed by murine macrophages. Discussed is the biologic value of such type of antibodies.

Animals↗