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Biomedical subjects

K Krishan

Publications and source records attributed to K Krishan.

15 recordsLinked to original sources
PubMed1989

Circannual rhythmicity in the occurrence of idiopathic priapism in north-western India.

A group of 26 patients who were operated upon for idiopathic priapism between 1972 and 1986 were classified according to the date on which they attended hospital. During the same 15-year period 150 patients with penile cancer were treated and they served as controls. The data were analysed for circannual rhythmicity (365.25 days = 360 degrees and 0 degrees = 22 December. This revealed a significant circannual rhythmicity in the occurrence of idiopathic priapism, with the acrophase located on 2 August. There was a significantly higher incidence of idiopathic priapism between April and September.

Adolescent↗
PubMed1989

The loss of circadian rhythmicity of urinary solute excretion in idiopathic stone formers.

Circadian rhythmicity in urinary volume and excretion of creatinine, calcium, oxalate, uric acid and phosphate was studied in 15 idiopathic stone formers and in 17 control subjects who were age-matched, related adult males, living in the same house and engaged in similar occupations to those of the stone patients, but who had no clinically obvious stone disease. Three-hourly urine samples were collected and creatinine, calcium, oxalate, uric acid and inorganic phosphate were estimated. The time series of data were analysed by cosinor rhythmometry. Circadian rhythmicity has been described in urinary volume and urinary excretion of creatinine, calcium, oxalate, uric acid and inorganic phosphate in normal subjects, but it was not detected in the stone formers. The control subjects exhibited a circadian rhythmicity only in urinary volume and creatinine excretion. Thus they occupied a position midway between healthy adults, who exhibit circadian rhythmicity in all of the above parameters, and the stone formers, who appear to have lost it altogether.

Adult↗
PubMed1989

Comparative study of the circadian rhythmicity in the urinary concentration of glycosaminoglycans in patients of calcium oxalate nephrolithiasis and in healthy adults.

Glycosaminoglycans (GAGs) are potent inhibitors of calcium oxalate crystallisation and/or crystal aggregation. Urinary concentration of GAGs has been shown to vary during 24 h; therefore, circadian rhythmicity in urinary concentration of GAGs was investigated in 33 healthy male adults in the age group of 20-40 years and in 27 male patients of a similar age group with calcium nephrolithiasis. Three-hourly urine samples were collected for 24 h beginning from 00.00 h for estimation of urinary concentration of GAGs. The data of each patient was analysed by single cosinor rhythmometry and population mean-cosinor rhythmometry was then applied to each group. Twenty-four-hour urinary excretion of GAGs was significantly less in renal calculus patients (16.867 +/- 5.89 mumol) than in healthy subjects (22.588 +/- 5.32 mumol; p less than 0.001). A statistically validated circadian rhythm in urinary concentration of GAGs was demonstrated in both the groups. However, the amplitude-acrophase test revealed a significant difference between the two groups (F2,57 = 8.305; p less than 0.001); the amplitude was 2.354 mumol/l in patients with nephrolithiasis, whereas the amplitude was 7.028 mumol/l in healthy adults. The mesor test also revealed a significant difference in the 3-hour urinary concentration of GAGs between the two groups (18.536 mumol/l in healthy adults vs. 9.728 mumol/l in patients with nephrolithiasis). Thus in patients with nephrolithiasis, not only is the 24-hour urinary excretion of GAGs significantly low but the 3-hourly urinary concentration of GAGs is also significantly decreased as compared to healthy subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

Skeletal muscle metabolism in mice bearing adenocarcinoma. III. Activities of alanine and aspartate aminotransferases.

Activities of alanine and aspartate aminotransferases in six skeletal muscles demonstrate 114-223% and 86-146% increase respectively, over the normal by the 10th week after adenocarcinoma transplantation in mice. The white (anaerobic) muscles reveal greater increment in these two enzymes than the red (aerobic) ones. The significance of elevated aminotransferase activities in energy metabolism of the host muscles is discussed.

Adenocarcinoma↗
PubMed1985

Skeletal muscle metabolism in mice bearing adenocarcinoma. II. Histochemical alterations in acid and alkaline phosphatases.

In Swiss albino mice bearing adenocarcinoma the degree of pathological damage as revealed by the activities of acid and alkaline phosphatases is greater in skeletal muscles closely proximal to the tumor site than in those away from it. Acid and alkaline phosphatases in myofibres of triceps, pectoralis and gastrocnemius muscles show a direct relationship between myofibre necrosis and activities of these phosphatases.

Acid Phosphatase↗
PubMed1985

Skeletal muscle metabolism in mice bearing adenocarcinoma. I. Histochemical alterations in glycogenolytic, glycolytic, lipolytic and oxidative metabolism.

Metabolism of triceps, pectoralis (in the vicinity of tumor) and gastrocnemius (away from the tumor) muscles in Swiss albino mice bearing adenocarcinoma has been studied histochemically with regard to content of glycogen, lipids, phosphorylase, aldolase, lipase, succinate dehydrogenase and cytochrome oxidase in the constituent fibres. At 9-10 weeks after transplantation of adenocarcinoma, a negligible glycogen content and decreased phosphorylase and aldolase activities are observed in the white, intermediate and red fibre types in the three muscles. Hypertrophy of fibres and occurrence of targetoid fibres is distinct in the muscles of tumor-bearing mice. The red fibres demonstrate a general loss of lipids, lipase, succinate dehydrogenase and cytochrome oxidase whereas the hypertrophied fibres reveal intense localization of these parameters in their central zones. The results indicate that a decline in glycogenolysis, glycolysis, lipolysis and oxidative metabolism in the various fibre types may contribute to the muscle weakness and muscle wasting in the adenocarcinoma-bearing mice.

Adenocarcinoma↗
PubMed1980

On the determination of skeletal muscle types in Swiss albino mouse.

Biochemical characteristics of the red, white and intermediate types of muscles have been studied with regard to the alterations in their glycogen, acid and basic proteins, nucleic acids (DNA and RNA) and SDH-activity, during the period of post-natal growth. The results of the investigation, which has been conducted on M, soleus, M. tibialis anterior and M. sartorius of Swiss albino mouse, indicate the predetermination of the biochemical characteristics of each muscle type with respect to the parameters studied and do not show post-embryonic differentiation.

Animals↗
PubMedDate not supplied

Circadian desynchronization in pulse rate, systolic and diastolic blood pressure, rectal temperature and urine output in traumatic tetraplegics.

An investigation was undertaken to study the circadian rhythmicity in pulse rate, systolic and diastolic blood pressure, rectal temperature and urine output in eight traumatic tetraplegics in view of the fact that diurnal rhythmicity in prolactin response to thyrotropin-releasing hormone was absent in such patients. The data, analysed by single cosinor procedure, showed absence of rhythmicity in all five parameters. Analysis of variance also showed no significant difference in these parameters at various time points. Knowledge of the alterations in circadian biology subsequent to cervical spinal cord trauma would provide useful guidelines towards chronotherapy and vocational rehabilitation of tetraplegics besides possible restoration of euchronism by pharmacological means.

Adolescent↗