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Biomedical subjects

K Kristoffersen

Publications and source records attributed to K Kristoffersen.

At least 55 records · Page 3Linked to original sources
PubMed1979

T and B lymphocytes during normal human pregnancy: a longitudinal study.

Immunological relationships in pregnancy were investigated in a longitudinal study of twenty-two pregnant women, whose blood samples were taken before pregnancy, during pregnancy, at delivery, and 3--5 months after delivery. Blood samples were also taken from the fathers and the infants, both at birth and after 3--5 months. All the samples were frozen by means of a cryobiological freezing system, and when a whole longtiudinal series had been collected, the material was thawed and tested in a single seance. T and B lymphocytes were studied with rosette tests (E and HEAC rosettes). T and B lymphocytes were found not to change during the course of pregnancy. It is thus concluded that the mother's tolerance of a fetus with a dissimilar tissue type is not exercised via changes in the total count of T and B lymphocytes, although there may well be changes in their subpopulations, with the hypothesis that T-suppressor function increases and B-lymphocyte function decreases.

Adult↗
PubMed1979

Prenatal diagnosis of polycystic kidneys and encephalocele (Meckel syndrome).

Two unrelated families are presented with repeated occurrences of a congenital syndrome of which the main stigmata were polycystic kidneys and occipital encephalocele (Meckel syndrome). Prenatal diagnosis, followed by interruption of pregnancy, was performed in one case. The diagnosis was based on an increase of amniotic alpha-fetoprotein (AFP), and on the mode of growth and cell types of cultured amniotic cells. In another similarly examined case the diagnosis was suspected, but the parents did not wish the pregnancy to be interrupted. The child was stillborn and malformed. AFP values are presented and discussed in relation to the observed malformations. Neural tube defects are associated with an increase of AFP in amniotic fluid, but, as in normal pregnancies, the values decrease with increasing gestational age. On the other hand, kidney malformations seem to be associated with AFP values which remain high or even increase with increasing gestational age.

Amniotic Fluid↗
PubMed1979

Folic acid supplement and intrauterine growth.

The effect of a folic acid supplment on birth weight and placental weight in women delivering in the early summer in Denmark was investigated. Thirty-six women with normal pregnancy and expected delivery in the first half of June were selected consecutively. They were paired two and two, and allotted to two groups, one of which was supplied daily with 5 mg folic acid, and the second with tablets without folic acid, from the 23rd week of pregnancy. A significant correlation was found between erythrocyte folic acid and birth weight. The infants in the folic acid group were 12.7 per cent heavier than those in the control group (p less than 0.01). A similar difference was found with regard to placental weight and the number of placental cells.

Birth Weight↗
PubMed1978

Cell-mediated immunity in pregnancy evaluated using lymphocyte transformation tests and rosette tests for T and B lymphocytes. A cross-section analysis.

In vitro tests of cellular immune response using lymphocyte transformation tests and rosette tests for T and B lymphocytes were studied in a cross-section analysis of a total of 55 patients in six groups (non-pregnant, 2-3 month pregnant, 4-5 month pregnant, 6-7 month pregnant, at parturition and 3 months after parturition). No pregnancy-related changes were found in the numbers of T, B or nil cells, nor changes in PHA, PWM or MLC responses. However, a significant reversible depression of the PPD response was found in the second half of pregnancy.

Adult↗
PubMed1978

Thyroid function during pregnancy with special reference to hydatidiform mole and hyperemesis.

The thyroid function tests, serum protein-bound iodine (PBI), serum triiodothyronine reaction (T3-test) and serum cholesterol were measured in three groups of pregnant women: 1) 57 with normal pregnancy, 2) 35 with hyperemesis and 3) 14 with hydatidiform mole. A pattern of high values of PBI and T3-test and relatively low values of cholesterol in most of the patients with hydatidiform mole, and in almost one third of the patients with hyperemesis was found. A positive correlation of the volume of molar tissue and the values of PBI was observed. The treatment of patients with hyperemesis mostly resulted in normalisation of the thyroid function tests, while this was not the case in patients with mole. It is suggested that there might be a common cause of the thyroid stimulation in patients with mole and hyperemesis.

Cholesterol↗
PubMed1977

Changes in serum lipids during treatment with norgestrel, oestradiol-valerate and cycloprogynon.

The serum concentrations of triglycerides, cholesterol, and free glycerol were determined in 23 climacteric women, before and after the administration of three different steroid drugs. Each drug was given within a period of 12 weeks (3 cycles). Period I: Norgestrel, 0.5 mg daily from the 12th to 21st day of each cycle. Period II: Oestradiol-valerate (Progynon) 2 mg daily from the 2nd to 21st day of each cycle. Period III: Oestradiol-valerate 2 mg from the 1st to 11th day followed by oestradiol-valerate 2 mg+0.5 mg dl-norgestresl from day 12 to 21 of each cycle (Cycloprogynon). A significant decrease in triglycerides was observed following the administration of norgestrel and Cycloprogynon, whereas oestradiol-valerate had no effect on the triglyceride levels. On the other hand, oestradiol-valerate, following a period of norgestrel, produced an increase in serum cholesterol levels.

Adult↗
PubMed1977

Cellular immunity in pregnancy: blast transformation and rosette formation of maternal T and B lymphocytes: A cross-section analysis.

In vitro tests of cellular immune responses, using lymphocyte transformation tests and rosette tests for T and B lymphocytes, were studied in a cross-section analysis of a total of fifty-five patients in six groups (non-pregnant, 2--3 months pregnant, 4--5 months pregnant, 6--7 months pregnant, at parturition and 3 months after parturition). No pregnancy-related changes were found in the numbers of T, B or null cells, nor changes in PHA, PWM or MLC responses, but a significant reversible depression of the PPD response was found in the second half of pregnancy.

Adolescent↗
PubMed1975

Correlation between human chorionic somatomammotropin and placental weight.

Human chorionic somatomammotropin concentration in serum (S-HCS) during the latter half of pregnancy was measured by radioimmunoassay and correlated to the placental weight, in two groups of normal, healthy, pregnant women. In one group, 228 samples from 47 women were examined, which gives a longitudinal series. In the other group, single samples from each of 346 pregnant women were examined, which gives a cross-sectional series. Both groups were randomized on the basis of a prospective selection. The mean values of S-HCS in each week of gestation were almost identical in the two groups, showing a steady increase until 37-38 weeks and a subsequent decrease. In the longitudinal series there was a positive correlation between the S-HCS and placental weight after 37 weeks' gestation, but not before that time. Before 37 weeks gestation the ratio S-HCS/placental weight was significantly higher with small placentae than with large placentae. This difference between small and large placentae disappeared after 37 weeks. These results point to the existence of some regulatory mechanism tending to keep the S-HCS concentration within certain limits, independent of placental weight. This mechanism appears to be lost after 37 weeks of gestation when the S-HCS concentration starts to correlate with placental weight.

Adolescent↗