Biomedical subjects

K Kyle

Publications and source records attributed to K Kyle.

11 recordsLinked to original sources

PubMed2006

Negative temperature programming using microwave open tubular gas chromatography.

A microwave gas chromatography (GC) column oven is engineered to generate a uniform microwave field around an open tubular column with the elimination of cold spots, which are common in a domestic microwave oven. Short cool-down time in microwave heating makes it possible to employ negative temperature programming for the enhanced separation of compounds during the process. The feasibility of negative temperature programming in microwave GC is investigated for the analysis and quantitation of four different pairs of nonvolatile and volatile compounds. The influence of intermediate column cooling rate, holding time in the cooling ramp, and reheating rate after the cooling ramp for enhanced resolution are investigated. The results obtained from negative temperature programming are compared with those from positive temperature programming. Negative temperature programming affords greater resolution of some critical pairs of analytes.

Journal Article↗

PubMed1999

Outcome of renal transplantation in patients with lower urinary tract abnormality.

Patients with end stage renal failure (ESRF) and lower urinary tract abnormality (LUTA) are often considered high risk for renal transplantation. To examine the degree of risk, we have reviewed our experience of 44 patients who received a total of 58 renal allografts at the Western Infirmary, Glasgow, between 1978 and 1996. All patients had a detailed urological assessment and 19 of them underwent a urinary diversion procedure prior to transplantation. One-year patient and graft survival rates were 97% and 84%, respectively, while the five-year figures were 87% and 59%, respectively. The presence of an ileal conduit did not adversely affect graft survival (P = 0.52). The commonest complication was persistent urinary tract infection, which occurred in 15 (34%) patients. Of the 29 graft losses that occurred during the follow up period of 7-217 months, only one was due to infection of the transplant. We conclude that renal transplantation is a satisfactory option for patients with ESRF due to LUTA but that it is important to carry out detailed urological assessment prior to the transplant procedure.

Adolescent↗

PubMed1982

Randomised trial of clomiphene citrate treatment and vitamin C for male infertility.

A prospective randomised trial was carried out to assess the effect of 6 months' treatment with either clomiphene citrate or vitamin C in 179 men complaining of infertile marriage. There was no significant difference in the wife's pregnancy rates between the 2 treatment groups. In order to detect a subgroup that might respond to clomiphene the results were analysed according to pre-treatment FSH and sperm density, with allowance being made for the result of the wife's tests, but still there was no significant difference in treatment response Vitamin C would seem a preferable and cheaper alternative treatment for male infertility.

Ascorbic Acid↗

PubMed1978

A renal carcinoma secreting inactive renin.

1. A patient presented with mild hypertension, a raised plasma total renin concentration but a normal plasma angiotensin II concentration. The discrepancy was due to a high concentration of inactive renin in the plasma. 2. A renal carcinoma was detected and removed. The tumour contained a higher proportion of inactive renin than was found in uninvolved areas of the kidney. After unilateral nephrectomy, the plasma concentration of inactive renin fell to normal. 3. Six months later, plasma inactive renin concentration again increased and a metastasis was detected in a rib. Excision of the rib together with radiotherapy resulted in a fall in plasma inactive renin to normal. 4. The inactive renin in plasma and tumour extracts was activated to the same extent by acid treatment and by trypsin.

Aged↗

PubMed1972

Renal transplantation: an analysis of 33 cases.

Thirty-three patients with end-stage renal failure have had transplants over a three-year period, four patients receiving kidneys from siblings and the remainder cadaver organs. Twenty-seven kidneys survived with stable function for periods of six months to three years. Graft survival at one year was 85% and at two years 82%. One patient died and five were returned to dialysis. Complications included rejection episodes, technical problems, respiratory and wound infections, gastrointestinal disorders, and side effects of steroids.

Acute Kidney Injury↗

PubMed1971