Squamous cell carcinoma in chronic trophic ulcers of leprosy patients.
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Aged↗
Biomedical subjects
K Kyriakis
Publications and source records attributed to K Kyriakis.
Multidrug resistance among methicillin-resistant Staphylococcus aureus in Greece.
A total of 472 strains of Staphylococcus aureus isolated in a university hospital in Thessaloniki, Greece during 1993-1994 were studied; 202 (42.8%) of them were characterized as methicillin-resistant (MRSA) and were mainly recovered from respiratory materials. The minimal inhibitory concentrations (MICs) of methicillin-susceptible (MSSA) and methicillin-resistant strains to 10 alternative antibiotics were also compared. All MRSA isolates were resistant to penicillin and most of them, in contrast to MSSA, exhibited resistance to gentamicin, tobramycin, tetracycline, erythromycin and ciprofloxacin with resistance rates ranging from 89.6% to 59.4%. Also, considerable proportions of MRSA were found resistant to co-trimoxazole (47.0%) and rifampicin (27.7%). All isolates were sensitive to vancomycin while susceptibility to chloramphenicol was of equal incidence among the examined populations. Overall, MRSA vs. MSSA exhibited a significantly (chi 2; P < 10-8) higher incidence of resistance to 8 out of the 10 antibiotics examined.
Chi-Square Distribution↗
Detection of autoimmunity parameters in the acquired immunodeficiency syndrome (AIDS).
We have examined various autoimmunity parameters in AIDS with special emphasis on the expression of pemphigus and bullous pemphigoid antibodies. Sera from healthy seropositive individuals without syphilis (CS-, n = 17), seropositive individuals with syphilis (cs+, n = 11), and patients with AIDS (n = 6) were studied and compared with normal controls (n = 30); autoimmunity parameters related to dermatology were evaluated. Indirect immunofluorescence (IIF) for pemphigus and pemphigoid antibodies, antinuclear antibodies (ANA), anti-DNA antibodies, antismooth muscle antibodies (ASMA) antimitochondrial antibodies (AMA), and antithyroid antibodies (ATA) was carried out and findings were graded with a cumulative index (CI) for each patient group. Pemphigus and bullous pemphigoid-like antibodies (IgG, PV + BP) were detected in 33% of the AIDS patients. Statistically increased CI (P less than 0.01) was found in the CS- group compared with the CS+ group and in the AIDS group compared with CS- (P less than 0.01).
Acquired Immunodeficiency Syndrome↗
Exposure effects of netilmicin on Enterobacter cloacae clinical isolates.
The effects of netilmicin exposure on two aminoglycoside (AMG)-resistant and two AMG-susceptible Enterobacter cloacae isolates were studied. It was found that 1 h incubation of bacterial suspensions with netilmicin at 16 mg/l reduces the amounts of lipopolysaccharides present on the bacterial surface. Also, netilmicin pretreatment increased both the susceptibility to normal human serum and the adhesion to human epithelial cells of all four E. cloacae strains examined.
Bacterial Adhesion↗
Coexistence of pemphigus vulgaris, malignant melanoma and low-grade lymphoma.
A 53-year-old female patient with pemphigus vulgaris under continuous immunosuppressive therapy for about 2 years presented a superficial spreading malignant melanoma on a pre-existing melanocytic naevus. After surgical removal of the inguinal lymph node group, a diffuse low-grade polymorphous immunocytoma was proved both histologically and immunocytochemically. The possible induction mechanisms are discussed.
Female↗
A five year retrospective study on pemphigus and pemphigoid.
In a five year period 73 cases of pemphigus vulgaris (PV) and 94 of bullous pemphigoid (BP) were studied to investigate important parameters for these diseases. From the results it was found that the incidence of PV was higher in women whereas that of BP was almost equal in both sexes. The incidence of PV was highest in the sixth decade but was highest in the eighth decade for BP. Indirect immunofluorescence (IIF) was more sensitive in PV whereas direct immunofluorescence (DIF) was more sensitive in BP. The present study provides a basis for comparison with results of previous or future studies in Greek and other populations.
Adult↗
Delayed hypersensitivity and differences of histologic pattern in allergic cutaneous vasculitis.
Fourteen patients with allergic cutaneous vasculitis of either the polymorphonuclear (PMN)- or the mononuclear (MN)-predominant type were studied as regards the following parameters: the disease duration, histology, monoclonal antibody typing of the mononuclear cell infiltrate from recent lesions, and the delayed hypersensitivity (DH) response, assessed both by recall antigens (tuberculin type) and the dinitrochlorobenzene skin test. From the results, it was shown that in PMN-predominant vasculitis, DH reactions were well elicited, whereas in MN-predominant vasculitis, DH skin reactions were somehow impaired. In MN-predominant cases, many OKT3+, OKT4+, OKT8+, and OKM1+ cells were usually seen to surround the skin vessels, whereas in PMN-predominant cases, rare OKT8+, OKT4+, or OKM1+ cells were seen in the dermis. The epidermal dendritic cell system, as revealed by the Na(1)34 monoclonal antibody, was unaffected in both types of allergic cutaneous vasculitis.
Adult↗