Analgesic use during pregnancy.
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Biomedical subjects
Publications and source records attributed to K L Harrison.
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Results are presented showing an association of maternal smoking during pregnancy with a reduction in the numbers of circulating neutrophils in their infants. It is postulated that such infants may be more susceptible to infection.
Chronic asymptomatic genital tract infection has been postulated to cause infertility in man. This study demonstrates the correlation of positive seminal fluid bacteriological cultures with abnormal parameters of seminal fluid analysis in the male partners of 100 uninvestigated couples presenting with infertility. Gram negative bacteria were cultured only in patients with semen abnormalities while Gram positive bacteria were cultured from both normal and abnormal semen specimens.
The results of postpartum fetal cell counting in 400 Rh-negative patients delivering Rh-positive infants are presented and correlated with the mode of delivery and the ABO blood group relationship of baby and mother. Manipulative procedures, especially Caesarean section, are shown to increase the incidence of macrotransfusion. To make the most economical use of the new 125 microgram doses of anti-D gamma globulin, quantitation of fetal-maternal transfusions is shown to be vital if the existing level of protection from rhesus sensitization is to be maintained or increased.
The case described demonstrates the development of elliptical stomatocytosis in a neonate and the appearance of elliptical stomatocytes in her mother whose blood film, before delivery, showed elliptocytosis. Further investigations on both individuals indicated a mild haemolytic anaemia. To our knowledge this is the second reported case of elliptical stomatocytosis.
Fetal cell counts were performed on pregnant women at 34 weeks' gestation following an injection of Anti-Rh O (D) gamma globulin at 28 weeks' gestation. In cases where the fetus subsequently proved to be Rh O (D) positive and ABO compatible, the fetal cell detection rate and the mean number detected detected were considerably less than those where the fetus was Rh negative. Postpartum fetal cell counts after one and two antenatal anti-Rh O (D) gamma globulin injections were also less when the baby was Rh positive than when the baby was Rh negative. These findings provide evidence that antigen clearance is definitely part of the mechanism involved in Rh prophylaxis by the use of anti-Rh O (D) gamma globulin.